Variability

Question 1

Name a few strategies to increase compliance

Answer 1

Education on why taking it, dose aides, Webster packs, alarms, simplifying therapy (combo products, sustained release)

Question 2

Name 3 environmental factors that can influence PK

Answer 2

Food, dinural variation, smoking

Question 3

Which drugs are most likely to have a different volume of distribution in obese patients? And therefore may require dose adjustments

Answer 3

Lipid soluble drugs - obese patients have more fat tissue and therefore the V might increase

Question 4

When is organ function typically mature after birth?

Answer 4

Around 12 months old

Question 5

Dosing for children is based on weight until when?

Answer 5

Until 50kg or until puberty is reached

Question 6

Dosing for obese children?

Answer 6

Typically dosed based on ideal body weight

Question 7

Why might BSA be used for dosing instead of weight?

Answer 7

It correlates to renal function and cardiac output better. Good for narrow TI drugs

Question 8

Impact of gender on PK?

Answer 8

Limited influence. Changes in body composition, hormones and enzyme expression could cause variation

Question 9

When would a dose adjustment be required for a patient with renal impairment?

Answer 9

If more than half of the drug is excreted unchanged in the urine

Question 10

Name a few mechanisms of drug interactions

Answer 10

Alterations in absorption, membrane transporters, metabolic enzymes, plasma protein binding, etc