Clearance Flashcards
1
Q
Clearance describes the relationship between which two variables?
A
The dose rate and the plasma concentration
2
Q
Units for clearance?
A
Volume / time
3
Q
What does MDR stand for
A
Maintenance dose rate
4
Q
What does AUC stand for
A
Area under the curve.
5
Q
Which two pathologies would alter clearance?
A
Pathology altering perfusion of the organ involved (e.g. HF = less blood to organ)
Pathology altering the organ function (damage to organ)
6
Q
Fub stands for?
A
Fraction of unbound drug.
I.e. fraction of the drug available to be metabolised
7
Q
Explain CL-int
A
The intrinsic ability of the enzymes (e.g. hepatic enzymes) to metabolism the drug.
8
Q
For drugs with low hepatic clearance, what is the rate limiting step of the clearance? CL-int or Fub?
A
CL-int
