voltage gated Na channels

Question 1

mechanism of local anaesthetics (lignocaine)

Answer 1

block Na channels to inhibit nerve conduction

Question 2

mechanism of neurotoxins (tetrodotoxin)

Answer 2

block Na entry into cell preventing depolarisation

Question 3

what type of sodium channels have a low sensitivity to TTX

Answer 3

cardiac sodium channels

Question 4

what is the beta subunit of Na important for

Answer 4

stability and modulation of channels
B1 responsible for epilepsy

Question 5

Nav 1.7 is related to

Answer 5

pain

Question 6

loss of function of Nav 1.7 causes a person to

Answer 6

not feel pain

Question 7

a mutation in what can cause periodic paralysis

Answer 7

Nav 1.4

Question 8

a mutation in what can cause epilepsy

Answer 8

Nav 1.1 and 1.2

Question 9

What type of channels are NaV1.5
Are they resistant/sensitive to TTX

Answer 9

Cardiac channels resistant to TTX

Question 10

What type of channels are NaV1.1+1.2
Are they sensitive/resistant to TTX

Answer 10

CNS channels
Sensitive to TTX

Question 11

What type of channels are NaV1.7+1.8

Answer 11

PNS channels

Question 12

A mutation in SCN5A causes which disease

Answer 12

Long QT syndrome