voltage gated Na channels Flashcards
1
Q
mechanism of local anaesthetics (lignocaine)
A
block Na channels to inhibit nerve conduction
2
Q
mechanism of neurotoxins (tetrodotoxin)
A
block Na entry into cell preventing depolarisation
3
Q
what type of sodium channels have a low sensitivity to TTX
A
cardiac sodium channels
4
Q
what is the beta subunit of Na important for
A
stability and modulation of channels
B1 responsible for epilepsy
5
Q
Nav 1.7 is related to
A
pain
6
Q
loss of function of Nav 1.7 causes a person to
A
not feel pain
7
Q
a mutation in what can cause periodic paralysis
A
Nav 1.4
8
Q
a mutation in what can cause epilepsy
A
Nav 1.1 and 1.2