Vitamins Flashcards
Fat soluble
A, D, E, K
Accumulated stores in body. Require absorption of dietary fat & carrier system for blood transport
Vitamin A
Essential in photochemical basis of vision
Preformed Vit A (retinol/retinal): liver, dairy products, egg yolks, fish oil
Precursor (carotenoids e.g. beta- carotene): abundant in deep • yellow/orange & green vegetables
Vitamin A Def
Night blindness, xerophthalmiam Bitot's spots Immune deficiency (measles, GI, children)
Vit A Tox
Only preformed (cod liver oil) Vomiting, increased ICP, HA, bone pain (periosteal proliferation), bone mineral loss (↑ fractures & ↑ osteoporosis), liver damage (hepatitis, fibrosis, liver failure); birth defects (acutane)
Vit D
Hormone. Maintains intra/extracellular Ca++ Stimulates intestinal absorption and renal reabsorption of Ca++ and P Innate immune function Cellular growth and differentiation RDA=600 IU/d (
Vit D Metabolism
Precursor (dehydrocholesterol) in skin converted to cholecalciferol (Vit D3)
by UV light
Vitamin D2 or D3 hydroxylated in
liver to 25-OH-cholecalciferol1,25- dihydroxy-cholecalciferol (calcitriol) in kidney = active form
Vit D Deficiency
Deficient: 25OH-D 30 ng/mL (>80 nmol/L)
Classic Triad in Serum: low C + low P + high alk phos (late)
Classic: Childhood ricketts. Adults osteoporosis
Vit D Tox
nephrocalcinosis & soft tissue calcification
Vit E
Antioxidant
Polyunsaturated vegetable oils, wheat germ
Vit E Def
Neurologic degeneration: with loss of reflexes (DTR’s)
hemolytic
anemia
Vit E Tox
coagulopathy (very large doses inhibit Vit K dependent factors)
Vit K
ssential for carboxylation of coagulation proteins (Factors “1972”X, IX, VII, II)
All newborns should receive single IM dose of 0.5-1.0 mg
Leafy vegetables, fruits, seeds
Vit K Def
Prolonged coagulation times; hemorrhagic disease of newborn: bleeding into skin (purpura), GI tract, CNS
B1
Thiamine. In metabolism. Whole grains, enriched grains, pork, legumes.
RDA: 1.1-1.2 mg/d
B1 Deficiency
Beriberi, dry: peripheral neuropathy distal, wrist/foot drop.
Wet berberi: edema, high output CF
Wernicke/Korsakoff: Triad = ocular signs (nystagmus, ophthalmoplegia), ataxia, and amnesia/confusion.
B1 risk groups
Alcoholics
Anorexia refeeding
Bariatric surgery
B2
Riboflavin. Part of 2 coenzymes - FAD, FMN (Krebs & oxidative)
Liver, wheat germ, dairy the most, meats/poultry, almonds, leafy greens. (UV destroys)
RDA: 1.1-1.3 mg/d
B2 Deficiency
Oral-ocular-genital syndrome Cheilosis (cracking of lips) and angular stomatitis (sores at
corner of mouth)
Increased vascularization of conjunctiva and photophobia
Seborrheic dermatitis and scrotal dermatitis.
B3
Niacin. In NAD & NADP - energy. Meats, poultry, fish, peanut butter, legumes=sources of preformed niacin.
Tryptophan is a precursor of niacinlarge amounts
of milk and eggs
RDA: 14-16 mg/d
B3 Def
Pellagra - 4 Ds
Dermatitis: characteristic symmetric pattern; aggravated by sun,
heat exposure
Dementia - confusion, dizziness, and hallcucinations Diarrhea
Death
B3 Tox
vasodilation & flushing
B3 Risk
Corn is major source of protein.
Metabolic “shunting” (eg carcinoid tumors producing excessive serotonin and shunt tryptophan
Reaction w/ isoniazid
Hartnup disease
Folate
1-carbon transfers, “Foliage” - deep green leaves, broccoli,
orange juice, whole grains (easily
destroyed w/ prolong cooking)
Fortification of grains in U.S. in 1998 → increased intakes
RDA: 400 μg/d
Folate Risk
Pregnant women, premature infants, Dilantin, sulfasalazine Chronic hemolytic anemia or blood loss
Folate Def
MACROcytic anemia, hypersegmented neutrophils, glossitis
Increased plasma homocysteine; Increased occurrence and recurrence of neural
tube defects
B12
Cobalamin. Critical in metabolism of odd chain length fatty acids
Re-form tetrahydrafolate. Animal products only! 1 carbon transfer
RDA: 2.4 μg/d
B12 def
MACROcytic anemia, hypersegmented
neutrophils, neurologic disturbances; Treatment with folate will correct anemia but
has NO effect on neurologic symptoms
B12 risk
inadequate absorption.
Pernicious anemia: hereditary condition with gastric atrophy in which IF is not produced or secreted
Strict vegetarian/vegan
B6
Pyridoxine. AA metabolism.
Animal products, vegetables, whole grains
RDA: 1.3-1.7 mg/day
Vit C
Ascorbic Acid. Antioxidant/reducing agent (electron donor)
Roles in collagen synthesis
Reduction of Fe3+ → Fe2+
leukocyte function. Fruits and vegetables.
RDA: 75-90 mg/d
Vit C Def
Scurvy: defective collagen formation
petechiae, bleeding
gums, anemia, bruising;
B6 Def
Anemia, seizures, glossitis; +/- depression
B6 Tox
Doses > 500 mg/d associated with sensory ataxia, impaired position/vibratory sensation
B6 Risk
Primarily associated with use of Isoniazid End-stage renal diseases,