Obesity Drugs Flashcards
Phentermine
Most widely prescribed
• 4-5% weight loss
Increase satiety, thus decreasing intake
• Only FDA approved for 3 mos
Phentermine SE
Nervousness, insomnia, HA, dry mouth
• Increase in blood pressure
Orlistat
safest weight loss drug
May prevent development of diabetes
Pancreatic lipase inhibitor that blocks about 1/3 of dietary fat absorption from the GI tract
• FDA approved for long-term use
Alli
OTC Orlistat
Xenical
Orlistat
Orlistat SE
Oily stools, sense of urgency, diarrhea, oily leakage
Fat soluble deficiency is not common
DDI: Increased INR with warfarin, decreased levels cyclosporine
Lorcasarin
4-5% weight loss
Selective serotonin 2C receptor agonist
Belviq
Lorcasarin
Phentermine/topiramate
Much greater weight loss (10-12%)
Combo of phentermine (increase satiety) and topiramate (anti-sz, anti-migraine drug)
Qsymia
Phentermine/topiramate
Topiramate SE
Teratogen
Dry mouth, paresthesias, insomnia, dizziness, anxiety, irritability, attention problems
Roux en Y Gastric Bypass
Dramatic benefits in glucose control in DM
28-30% weight loss – most effective, most risky
Food goes straight into intestine (without going through stomach) increased satiety
• Decrease in serum ghrelin=decreased hunger
RYGB SE
Risk of dying in first month post op is
Lap Band
20-24% weight loss – least weight loss, least risk
Is reversible
Reduce size of stomach to increase satiety
Lap Band SE
Risk of mechanical failure (erosion of band
through stomach wall, slippage of band)
Sleeve Gastrectomy
Benefits in glucose control in DM but not as much RYGB
• 24-27% weight loss; intermediate loss, intermediate risk
Removal of a portion of the stomach to increase satiety
Sleeve SE
“Intermediate” surgical option no mechanical problems (like in lap band) or nutritional def
