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Metabolism Part 2 > Obesity Drugs > Flashcards

Obesity Drugs Flashcards

1
Q

Phentermine

A

Most widely prescribed
• 4-5% weight loss
Increase satiety, thus decreasing intake
• Only FDA approved for 3 mos

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2
Q

Phentermine SE

A

Nervousness, insomnia, HA, dry mouth

• Increase in blood pressure

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3
Q

Orlistat

A

safest weight loss drug
May prevent development of diabetes
Pancreatic lipase inhibitor that blocks about 1/3 of dietary fat absorption from the GI tract
• FDA approved for long-term use

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4
Q

Alli

A

OTC Orlistat

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5
Q

Xenical

A

Orlistat

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6
Q

Orlistat SE

A

Oily stools, sense of urgency, diarrhea, oily leakage
Fat soluble deficiency is not common
DDI: Increased INR with warfarin, decreased levels cyclosporine

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7
Q

Lorcasarin

A

4-5% weight loss

Selective serotonin 2C receptor agonist

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8
Q

Belviq

A

Lorcasarin

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9
Q

Phentermine/topiramate

A

Much greater weight loss (10-12%)

Combo of phentermine (increase satiety) and topiramate (anti-sz, anti-migraine drug)

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10
Q

Qsymia

A

Phentermine/topiramate

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11
Q

Topiramate SE

A

Teratogen

Dry mouth, paresthesias, insomnia, dizziness, anxiety, irritability, attention problems

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12
Q

Roux en Y Gastric Bypass

A

Dramatic benefits in glucose control in DM
28-30% weight loss – most effective, most risky
Food goes straight into intestine (without going through stomach) increased satiety
• Decrease in serum ghrelin=decreased hunger

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13
Q

RYGB SE

A

Risk of dying in first month post op is

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14
Q

Lap Band

A

20-24% weight loss – least weight loss, least risk
Is reversible
Reduce size of stomach to increase satiety

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15
Q

Lap Band SE

A

Risk of mechanical failure (erosion of band

through stomach wall, slippage of band)

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16
Q

Sleeve Gastrectomy

A

Benefits in glucose control in DM but not as much RYGB
• 24-27% weight loss; intermediate loss, intermediate risk
Removal of a portion of the stomach to increase satiety

17
Q

Sleeve SE

A

“Intermediate” surgical option  no mechanical problems (like in lap band) or nutritional def

Metabolism Part 2 (11 decks)

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