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Metabolism Part 2 > Protein Biochem > Flashcards

Protein Biochem Flashcards

1
Q

Sulfur containing AA

A

Cysteine & Methionine

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2
Q

Aromatic

A

Tryptophan, phenylalanine, tyrosine

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3
Q

Hydroxyproline

A

collagen for H bonding

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4
Q

Hydroxylysine

A

collagen for interchain cross-links

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5
Q

G-Carboxyglutamate

A

target protein to membranes via Ca chelation

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6
Q

Pyridoxal Phosphate

A

derivative of B6. Used to ‘hold’ the amino groups

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7
Q

Urea Cycle combined Eq

A

3 ATP + HCO3 + NH4 +aspartate -> 2ADP + AMP + 2Pi + PPi + fumarate + urea

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8
Q

Urea Cycle Step 1

A

Ornithine -> Citrulline (catalyzed by Carbamoyl phosphate synthetase I

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9
Q

Carbamoyl P Synthetase I

A

mitochondria. Activator: N-acetylglutamate

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10
Q

Urea Cycle Step 2

A

Citrulline + Aspartate –> Argininosuccinate (catalyzed by Arginonosuccinate synthase)

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11
Q

Urea Cycle Step 3

A

Argininosuccinate -> Arginine (catalyzed by Argininosuccinate lyase)

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12
Q

Urea Cycle Step 4

A

Arginine -> Ornithine + Urea (catalyzed by Arginase)

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13
Q

Glucogenic AA Nonessential

A

Alanine, Arginine, Asparagine, Aspartate, Cysteine, Glutamate, Glutamine, Glycine, Proline, Serine

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14
Q

Glucogenic AA Essential

A

Histidine, Methionine, Threonine, Valine

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15
Q

Gluco & Ketogenic Nonessential

A

Tyrosine

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16
Q

Gluco & Ketogenic Essential

A

Isoleucine, Phenyl-alanine, Tryptophan

17
Q

Ketogenic AA

A

Leucine, Lysine

18
Q

Glutathione

A

Tripeptide of Glu, Cys, & gly. Controls cysteine redox potential

19
Q

Methionine Degradation

A
  • -> SAM –> SAH –> homocysteine
  • -> Met by methionine synthase Or
  • -> cystathionine by C B-synthase –> cysteine by C y-lyase
20
Q

Hyperhomocysteinemia

A

Elevated. Can cause CVD. Caused by low folate, B6, B12 –> used to treat

21
Q

Cysteinuria

A

Kidney stones (renal failure). From defective cysteine transporter. Treat w/acetazolamide

Metabolism Part 2 (11 decks)

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