viruses exam 2 Flashcards
chapter 6
viruses need what
a living host to replicate
obligate intracellular parasite
viruses
infectious agent to small to be seen by the naked eye
host range
each group of viruses infects a particular group or host
tissue tropism
the range of tissue types a virus can infect
virus specificity
the cells which a virus can infect
transmission of viruses
direct
indirect
vector
zoonose
virus is passed from animal to human
reverse zoonose
virus passed from human to animal
viral component
virion
nucleic acid
capsids
envelopes
spikes
nucleocapsid
virion
complete virus particle
nucleic acid
dna or rna
linear or circular
single or double stranded
capsids
protect and enclose the nucleic acid
composed of capsomeres
envelope
bilayer membrane
acquired when they bud from the cell
lipids proteins and carbs
spikes
glycoproteins: mediate attachment to the host
viruses do not have
ATP generating mechanisms
ribosomes
virus shaped determined by
envelope and capsomeres
teguments
proteins between envelope and capsid that may help with viral replication
international committee of taxonomy of virus
morphology
viral genetics
chemistry
mechanism of multiplication
Baltimore classification
genome type
mRNA generation
group 1
double-stranded DNA is transcribed to mRNA
group 2
single-stranded DNA generate a double-stranded and transcribed into mRNA
group 3
double-stranded RNA makes mRNA by using RNA dependent RNA polymerase
group 4
single-stranded RNA (+) makes complimentary - copy and transcribed to mRNA
group 5
single-stranded RNA - transcribed to mRNA
group 6
single stranded RNA + reverse transcribed to DNA
group 7
double-stranded DNA transcribed to mRNA and reverse transcribed to make viral genomes for packaging into virions
family name ends in
viridae
genus name
virus
viral species
group of viruses sharing the same genetic information and ecological niche (host)
replication of DNA containing animal virus
- Attachment: virion attaches to host
- entry and uncoated: virion enters and its DNA is uncoated
- A portion of viral DNA is transcribed, producing mRNA that encodes early viral proteins
- biosynthesis: viral DNA is replicated and some viral proteins are made
- late translation: capsid proteins synthesized
- maturation
- release
viroids
smaller than virus RNA particles
viroids differ in 6 ways from viruses
1.single stranded RNA, circular
2.exist inside the cell as particles of RNA w/out envelope
3.do not require helper virus
4.viroid RNA: no proteins
5. copied in nucleus/chloroplast
6. particles not apparent in infected tissues
virusoids
similar size/structure to viroids but are dependent on and encapsulated in helper virus
prions
resistant to inactivation at 90
resistant to enzymes that degrade RNA/DNA
not sensitive to radiation treatment
sensitive to protein denaturing agents
direct pairing to amino acids
oncogenic DNA viruses
adenoviridae
herpesviridae
poxviridae
papovaviridae
hepadnaviridae
oncogenic RNA VIRUS
viral RNA is transcribed to DNA which can be integrated in the host DNA
retroviridae
HTLV-1
HTLV-2