smallpox Flashcards
exam 1
1
Q
infectious agent
A
Variela virus (VARV)
2
Q
dsDNA
A
has double stranded DNA
3
Q
genus
A
orthopoxvirus
4
Q
what is smallpox specificity
A
humans
5
Q
what is transmission for smallpox
A
human to human
6
Q
when did WHO eradicate smallpox
A
1980
7
Q
where are the vials for smallpox
A
BSL-4 labs
8
Q
what virus is similar to smallpox in Africa
A
monkeypox but is less deadly
9
Q
incubation period
A
7-19 days
10
Q
signs symptoms
A
- initial symptoms: high fever, head and body aches, vomiting (sometimes contagious)
- early rash: The most contagious stage lasts 4 days
- pustural rash and scabs: last abt 10 days is contagious
- scabs fall off: 6 days contagious
- no scabs: abt four weeks after rash appears, all scabs fall off person no longer contagious
11
Q
two clinical forms
A
variola major: severe/most common
- fatality: 30%
variola minor: less common/severe
- fatality <1%
12
Q
diagnosis
A
isolation of virus from blood samples or pustule liquid
13
Q
treatment
A
July 2018 FDA approved tecovirimat for treatment
14
Q
identification
A
cultures
serologic test for virus antibodies
15
Q
other treatments shown effective
A
cidofovir/brincidofovir
