Bubonic plague Flashcards
exam 1
what is the causative agent of the plague
gram-negative bacterium Yersinia pestis
transmission of plague
getting bit by fleas who ate infected animals
eating infected animals
direct contact w infected persons/animals
incubation period
1-6 days
symptoms of bubonic
rapid onset of fever, painful swollen lymph nodes,
symptoms of pneumonic
high fever, pneumonia, cough, bloody sputum, chills
symptoms of septicemic
fever, prostration, hemorrhagic or thrombotic phenomena, progressing to necrosis
what is the deadliest plague
pneumonic
death rates of plagues of left untreated
30-60 % : bubonic
100% fr both pneumonic and septicemic
diagnostic sample of the plague
isolation of bacteria from bubo aspirates, blood cultures or sputum cultures
identification of plague
cultures
serologic test for Y pestis f1 antigen
antibiotics of the plague
gentamicin
doxycycline
ciprofloxacin
levofloxacin
vaccines for plague
killed whole cell vaccine
live attenuated vaccine
subunit vaccine
monoclonal antibodies