Viruses Flashcards
DNA viruses are ds EXCEPT
Parvo (ss)
All DNA viruses
Are HHAPPPy
Hepadna, Herpes, Adeno, Pox, Parvo, Papilloma, Polyoma
DNA viruses are linear EXCEPT
Papilloma and polyoma (circular, supercoiled) and hepadna (circular, incomplete)
DNA viruses are icosahedral EXCEPT
Poxvirus (complex)
DNA viruses replicate in the nucleus EXCEPT
Pox (carries own DNA-dependent RNA polymerase)
Enveloped viruses get their envelope from host’s plasma membrane EXCEPT
Herpesviruses - get their envelope from host’s nuclear membrane
Naked viruses
CPR and PAPP
Calci, Picorna, Reo, Parvo, Adeno, Papilloma, Polyoma
RNA viruses are ss EXCEPT
Reoviridae
RNA viruses replicate in the cytoplasm EXCEPT
Influenza and retroviruses
Positive stranded RNA viruses
I went to a RETRO TOGA party where I drank FLAVored CORONA and ate hippy (HEPE) CALcIfornia PICkles.
Live attenuated vaccines
Smallpox, yellow fever, vzv, Sabin polio, MMR
No boosters needed, do not give to immunocompromised
Killed vaccines
Rabies, influenza, Salk polio, HAV
Recombinant vaccines
HBV, HPV
Polyoma viruses
JC - junky cerebrum
BK - bad kidney
HHV-6
Roseola
Mononucleosis
EBV or CMV (negative monospot test)
EBV “downy cells” are which lymphocyte? EBV infects which lymphocyte line?
T cells = “downy cells”
B cells are infected
Negative stranded RNA viruses
Always Bring Polymerase Or Fail Replication
Arena, Bunya, Paramyxo, Orthomyxo, Filo, Rhabdo
Segmented RNA viruses
Bunya, Orthomyxo, Arena, Reo
BOAR
Parotitis, orchitis, aseptic meningitis
Mumps (Paramyxo)
Koplic spots, descending maculopapular rash (head to toe), encephalitis, subacute sclerosing Pan-encephalitis years later
Measles (Paramyxo) rubeola
Fever, postauricular adenopathy, LAD, arthralgia, fine truncal rash starts at head and moves down
Rubella (toga)
Seal-like barking cough
Croup (Paramyxo)
Bullet shaped capsid
Rabies - negri bodies in purkinje cells of cerebellum
HBsAg marks
Active hep b disease
Anti-HBsAg marks
Recovery from exposure
HBcAg marks
New disease
Anti-hBcAg
History of disease
HBeAg marks
Increased contagiousness
Anti-HBeAg marks
Decreased contagiousness
Gp120
Attachment to host cell, binds CXCR4 or CCR5 and CD4
Gp41
Fusion and entry to host cell
Gag
Encodes capsid protein
Env
Encodes for gp120 and gp41
HIV genome
Diploid
CCR5 mutation
Resistance or immunity to HIV
CD4<400
Oral thrush
CD4<200
JC virus reactivation - encephalopathy, PCP - pneumonia, cryptosporidium diarrhea
CD4<100
Histoplasma capsulatum, esophageal thrush, toxoplasma gondii - cerebral abscesses
CD4<50
Cryptococcus neoformans - meningitis (India ink stain), CMV retinitis or esophagitis, MAC TB like illness