Drug reactions

Question 1

Coronary vasopasm

Answer 1

Cocaine, Sumitriptan, ergot alkaloids

Question 2

Cutaneous flushing

Answer 2

Vancomycin, Adenosine, Niacin, Ca channel blockers- VANC

Question 3

Dilated cardiomyopathy

Answer 3

Doxorubicin (adriamycin), Daunorubicin

Question 4

Torsades de pointes

Answer 4

Class III (satolol) and class IA (quinidine) antiarrhythmics.
Tx with Mg

Question 5

Agraulocytosis

Answer 5

Clozapine, Carbamazepime, Colchicine, PTU< Methimazole, Dapsone

Question 6

Aplastic Anemia

Answer 6

Chloramphenicol, benzene, NSAIDs, PTU, methimazole

Question 7

Direct Coombs positive hemolytic anemia

Answer 7

Methyldopa, Penicillin

Question 8

Gray baby syndrome

Answer 8

Chloramphenicol

Question 9

Hemolysis in G6PD pts

Answer 9

INH, sulfonamides, Primaquine, ASA, Ibuprofen, Nitrofurantoin

Question 10

Megaloblastic anemia

Answer 10

Phenytoin, Methotrexate, Sulfa drugs

Question 11

Thrombotic complications- swollen lengs, pulmonary embolism

Answer 11

OCPs- Estrogens

Question 12

Cough

Answer 12

ACE inhibitors

Question 13

Pulmonary fibrosis

Answer 13

Bleomycin, Amiodarone, Busulfan

Question 14

Acute cholestatic hepatitis, jaundice

Answer 14

Erythromycin

Question 15

Focal to massive hepatic necrosis

Answer 15

Halothane, Amanita phalloides, Valproic Acid, APAP

Question 16

Hepatitis

Answer 16

INH

Question 17

Pseudomembranous colitis

Answer 17

Clindamycin, Ampicillin, cephalosporin

Question 18

Pancreatitis

Answer 18

Azathioprene, sulfonamides, corticosteroids

Question 19

Adrenocortical insufficiency

Answer 19

Glucoroticoid withdrawal due to HPA suppression

Question 20

Gynecomastia

Answer 20

Spironolactone, digitalis, Cimetidine, Alcohol, Estrogens, Ketoconazole
(Some Drugs Create Awkward Knockers)

Question 21

Hot flashes

Answer 21

Tamoxifen, clomiphene

Question 22

Hyperglycemia

Answer 22

Niacin, tacrolimus, protease inhibitors, HCTZ, corticosteroids

Question 23

Hypothyroidism

Answer 23

Li, Amiodarone, Sulfonamides

Question 24

Fat redistribution

Answer 24

Glucoccorticoids, Protease inhibitors

Question 25

Gingival hyperplasia

Answer 25

Phenytoin Verapamil

Question 26

Gout

Answer 26

Furosemide, Thiazides, Niacin, Cyclosporine

Question 27

Myopathies

Answer 27

Fibrates, Niacin, Colchicine, Hydroxychloroquine, IFN alpha, penicillamine, statins, glucoccorticoids

Question 28

Osteoperosis

Answer 28

Corticosteroids, Heparin

Question 29

Photosensitivity

Answer 29

Sulfonamides, Amiodarone, Tetracycline

Question 30

Rash- Stevens- Johnson Syndrome

Answer 30

Penicillin, Ehtosuxamide, Carbamazepine, Sulfa drugs, Lamotrigine, Allopurinol, Phenytoin, Phenobarbital

Question 31

SLE like syndromes

Answer 31

Hydralazine, INH, Procainamide, Phenytoin

Question 32

Effect kids teeth

Answer 32

Tetracycline

Question 33

Tendonitis, tendon rupture, cartilage damage

Answer 33

Fluroquinolones

Question 34

Diabetes Insipidus

Answer 34

Li, demeclocycline

Question 35

Fanconi's syndrome

Answer 35

Expired tetracycline

Question 36

Hemorrhagic Cystitis

Answer 36

Cyclophosphamide, Ifosfamide | Prevent with coadmin of Mesna

Question 37

Interstitial nephritis

Answer 37

Methicillin, NSAIDs, furosemide

Question 38

SIADH

Answer 38

carbamazepine, cyclophosphamide

Question 39

Cinchonism

Answer 39

Quinidine, Quinine

Question 40

Parkinson like syndrome

Answer 40

Antipsychotis, reserpine, metoclopramide

Question 41

Seizures

Answer 41

Isoniazid, Burpoprion, Imipenem/Cislastin, Tramadol, Enflurane, Metoclopramide

Question 42

Tardive Dyskinesia

Answer 42

Antipsychotics

Question 43

Antimuscarinin

Answer 43

Atropine, TCAs, H1 blockers, neuroleptics

Question 44

Disulfram like reactions

Answer 44

Metronidazole, cephalosporins, procarbazine, 1st gen sulfonylureas

Question 45

Nephrotoxicity/ ototoxicity

Answer 45

Aminoglycosides, vancomycin, loop diuretics, cisplatin

Question 46

CYP 450 Inducers

Answer 46

``` Modafinil Barbituates St.John's wart Phenytoin Rifampin Griseofluvin Carbamazepine Chronic alcohol use Momma Bard Steals Phen-phen and Refuses Greasy Carbs Chronically ```

Question 47

CYP 450 Inhibitors

Answer 47

``` Macrolides Amiodarone Grape fruit juice Isoniazid Cimetidine Ritonavir Acute alcohol abuse Ciprofloxacin Ketoconozale Sulfonamides Gemfibrozil Quinidine MAGIC RACKS in GQ ```