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Drug reactions Flashcards

1
Q

Coronary vasopasm

A

Cocaine, Sumitriptan, ergot alkaloids

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2
Q

Cutaneous flushing

A

Vancomycin, Adenosine, Niacin, Ca channel blockers- VANC

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3
Q

Dilated cardiomyopathy

A

Doxorubicin (adriamycin), Daunorubicin

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4
Q

Torsades de pointes

A 
Class III (satolol) and class IA (quinidine) antiarrhythmics.
Tx with Mg
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5
Q

Agraulocytosis

A

Clozapine, Carbamazepime, Colchicine, PTU< Methimazole, Dapsone

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6
Q

Aplastic Anemia

A

Chloramphenicol, benzene, NSAIDs, PTU, methimazole

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7
Q

Direct Coombs positive hemolytic anemia

A

Methyldopa, Penicillin

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8
Q

Gray baby syndrome

A

Chloramphenicol

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9
Q

Hemolysis in G6PD pts

A

INH, sulfonamides, Primaquine, ASA, Ibuprofen, Nitrofurantoin

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10
Q

Megaloblastic anemia

A

Phenytoin, Methotrexate, Sulfa drugs

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11
Q

Thrombotic complications- swollen lengs, pulmonary embolism

A

OCPs- Estrogens

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12
Q

Cough

A

ACE inhibitors

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13
Q

Pulmonary fibrosis

A

Bleomycin, Amiodarone, Busulfan

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14
Q

Acute cholestatic hepatitis, jaundice

A

Erythromycin

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15
Q

Focal to massive hepatic necrosis

A

Halothane, Amanita phalloides, Valproic Acid, APAP

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16
Q

Hepatitis

A

INH

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17
Q

Pseudomembranous colitis

A

Clindamycin, Ampicillin, cephalosporin

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18
Q

Pancreatitis

A

Azathioprene, sulfonamides, corticosteroids

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19
Q

Adrenocortical insufficiency

A

Glucoroticoid withdrawal due to HPA suppression

20
Q

Gynecomastia

A

Spironolactone, digitalis, Cimetidine, Alcohol, Estrogens, Ketoconazole
(Some Drugs Create Awkward Knockers)

21
Q

Hot flashes

A

Tamoxifen, clomiphene

22
Q

Hyperglycemia

A

Niacin, tacrolimus, protease inhibitors, HCTZ, corticosteroids

23
Q

Hypothyroidism

A

Li, Amiodarone, Sulfonamides

24
Q

Fat redistribution

A

Glucoccorticoids, Protease inhibitors

25
Q

Gingival hyperplasia

A

Phenytoin Verapamil

26
Q

Gout

A

Furosemide, Thiazides, Niacin, Cyclosporine

27
Q

Myopathies

A

Fibrates, Niacin, Colchicine, Hydroxychloroquine, IFN alpha, penicillamine, statins, glucoccorticoids

28
Q

Osteoperosis

A

Corticosteroids, Heparin

29
Q

Photosensitivity

A

Sulfonamides, Amiodarone, Tetracycline

30
Q

Rash- Stevens- Johnson Syndrome

A

Penicillin, Ehtosuxamide, Carbamazepine, Sulfa drugs, Lamotrigine, Allopurinol, Phenytoin, Phenobarbital

31
Q

SLE like syndromes

A

Hydralazine, INH, Procainamide, Phenytoin

32
Q

Effect kids teeth

A

Tetracycline

33
Q

Tendonitis, tendon rupture, cartilage damage

A

Fluroquinolones

34
Q

Diabetes Insipidus

A

Li, demeclocycline

35
Q

Fanconi’s syndrome

A

Expired tetracycline

36
Q

Hemorrhagic Cystitis

A

Cyclophosphamide, Ifosfamide

Prevent with coadmin of Mesna

37
Q

Interstitial nephritis

A

Methicillin, NSAIDs, furosemide

38
Q

SIADH

A

carbamazepine, cyclophosphamide

39
Q

Cinchonism

A

Quinidine, Quinine

40
Q

Parkinson like syndrome

A

Antipsychotis, reserpine, metoclopramide

41
Q

Seizures

A

Isoniazid, Burpoprion, Imipenem/Cislastin, Tramadol, Enflurane, Metoclopramide

42
Q

Tardive Dyskinesia

A

Antipsychotics

43
Q

Antimuscarinin

A

Atropine, TCAs, H1 blockers, neuroleptics

44
Q

Disulfram like reactions

A

Metronidazole, cephalosporins, procarbazine, 1st gen sulfonylureas

45
Q

Nephrotoxicity/ ototoxicity

A

Aminoglycosides, vancomycin, loop diuretics, cisplatin

46
Q

CYP 450 Inducers

A 
Modafinil
Barbituates
St.John's wart
Phenytoin
Rifampin
Griseofluvin
Carbamazepine
Chronic alcohol use
Momma Bard Steals Phen-phen and Refuses Greasy Carbs Chronically
47
Q

CYP 450 Inhibitors

A 
Macrolides
Amiodarone
Grape fruit juice
Isoniazid
Cimetidine
Ritonavir
Acute alcohol abuse
Ciprofloxacin
Ketoconozale
Sulfonamides
Gemfibrozil
Quinidine
MAGIC RACKS in GQ

USMLE (12 decks)

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