Virus Families Flashcards

1
Q

type of pathogen of virus

A
  • obligate intracellular parasite

- can only replicate inside a host cell

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2
Q

outside of virus

A
  • may be enveloped or naked
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3
Q

viral genomes

A
  • DNA

- RNA

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4
Q

different steps in virus life cycle may provide

A
  • targets for antiviral therapy
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5
Q

generic virus life cycle

A
  • attachment
  • entry
  • uncoating
  • synthesis of protein and nucleic acid
  • assembly
  • release
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6
Q

main components of viruses

A
  • protein
  • nucleic acids
  • lipids
  • sugars
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7
Q

virion

A
  • entire virus particle
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8
Q

envelope

A
  • may have glycoprotein spike
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9
Q

capsid

A
  • protein coat surrounding inner part of virus

- basic unit of structure

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10
Q

nucleocapsid

A
  • protein coat surrounding genome
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11
Q

capsomere

A
  • subunit
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12
Q

envelope derived from

A
  • host cell membranes
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13
Q

envelope contains

A
  • virally encoded proteins that are usually glycoproteins
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14
Q

envelope glycoproteins form

A
  • spike on surface
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15
Q

envelope virus morphology

A
  • pleomorphic

- determined by cell of origin

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16
Q

functions of capsid proteins

A
  • protects viral nucleic acid from environmental stress
  • interacts specifically with viral nucleic acid for packaging
  • interacts with host receptors for entry to cell
  • release of nucleic acid upon entry into new cell
  • viral and/or host gene regulation
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17
Q

how HIV is unique

A
  • nucleocapsid and capsid
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18
Q

isocahedral viruses

A
  • vast majority
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19
Q

isocahedral viruses shape

A
  • spherical
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20
Q

isocahedral viruses limitation

A
  • amount of nucleic acid limited by size of particle

- closed

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21
Q

helical virus shape

A
  • rod-shaped
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22
Q

helical virus limitation

A
  • no limit to amount of nucleic acid that can be packaged

- open

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23
Q

DNA viruses examples

A
  • Poxviridae
  • Herpesviridae
  • Adenoviridae
  • Papovaviridae
  • Hepadnaviridae
  • Parvoviridae

PHAP HP

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24
Q

viral genome functions

A
  • genome replication
  • genome assembly and packaging
  • regulation of replication cycle
  • modulation of host defenses
25
Q

not in genome

A
  • genes that encode for protein synthesis machinery
  • energy metabolism
  • membrane biosynthesis
26
Q

outer envelope of enveloped virus composed of

A
  • phospholipids
  • proteins
  • glycoproteins
27
Q

enveloped virus released by

A
  • budding
28
Q

enveloped virus in heat, acids, drying

A
  • sensitive
29
Q

enveloped virus and GI tract disease

A
  • less likely
30
Q

non enveloped virus outer covering

A
  • capsid protein
31
Q

non enveloped virus released by

A
  • lysis
32
Q

noneveloped virus in heat, acids, dyring

A
  • resistant
33
Q

non enveloped virus in GI tract

A
  • survive GI tract
34
Q

which viruses are more likely to be latent

A
  • DNA viruses
35
Q

RNA virus replication more prone to

A
  • errors
36
Q

what do RNA viruses use for replication

A
  • virus-encoded enzymes
37
Q

what do DNA viruses use for replication

A
  • host enzymes
38
Q

example of grouping by disease process

A
  • viral hepatitis
39
Q

hep A virus

A
  • picornavirus

- +ssRNA

40
Q

hep B virus

A
  • orthohepadnavirus

- dsDNA

41
Q

hep C virus

A
  • hepacivirus

- +ssRNA

42
Q

hep D virus

A
  • deltavirus

- -ssRNA

43
Q

herpesvirus family examples

A
  • HSV-1
  • HSV-2
  • VZV
  • CMV
  • EBV
44
Q

alpha herpes viruses examples

A
  • HSV-1

- HSV-2

45
Q

alpha herpes virus action

A
  • establish clinical latency in neuroglanglia
46
Q

beta and gamma herpes virus action

A
  • infect lymphocytic cells
47
Q

primary infection HSV-1 HSV-2

A
  • mouth or genital herpes
48
Q

HSV-1 HSV-2 infection via

A
  • direct contact
49
Q

HSV-1 HSV-2 reactivation

A
  • cold sore

- genital herpes

50
Q

VZV which one more contagious

A
  • chickenpox
51
Q

varicella complication

A
  • bacterial superinfection
  • pneumonitis
  • hepatitis
  • encephalitis
52
Q

clue for varicella infection

A
  • unilateral on one side
  • band on back
  • painful
53
Q

symptomology of CMV

A
  • asyptomatic

- can be infectious mono

54
Q

disease of CMV

A
  • congenital infections

- disease in immunocompromised

55
Q

EBV cause

A
  • infectious mononucleosis
56
Q

Influenza A virus group

A
  • orthomyxovirus
57
Q

influenza A virus nucleic acid

A
  • -ssRNA

- segmented

58
Q

another important virus with a segmented genome

A
  • rotavirus
59
Q

subtypes named based on

A
  • envelope hemagglutinin

- neuraminidase