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Virus Flashcards

1
Q

Human papilloma virus associated diseases

A

Hpv 1 2 6 11 - benign warts

16 and 18 cervical anogenital and oropharyngeal carcinoma

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2
Q

Why is HPV oncogenic?

A

Because it has oncoproteins E6 and E7 which target p53 and pRb tumour suppressor pathways
Increased mutations and cancer

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3
Q

What is molluscum contagiosum?

A

Pox virus infection
Umbilicated flesh papules
Epidermal hyperplasia with eosinophilic intracytoplasmic inclusions

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4
Q

All DNA. Viruses are double stranded except?

A

Parvo virus which is ss

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5
Q

All dna viruses have linear genomes except

A

Polyoma
Papilloma
Hepadna partially circular dsdna

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6
Q

Name the enveloped DNA VIRUSES

A

HHP
Herpes
Hepadna Pox

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7
Q

Name the non enveloped DNA Viruses

A

Polyoma
Papilloma
Parvo
Adeno

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8
Q

All DNA Viruses get their envelope from plasma membrane while budding except

A

Herpes which gets env from nuclear membrane

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9
Q

All DNA viruses replicate in nucleus except

A

Pox virus
Which replicates in cytoplasm
Because it has its own dna dependent rna polymerase

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10
Q

Diseases of polyoma virus

A

JC VIRUS- pml in hiv or immunosuppressed

BK VIRUS- transplant patient causes nephropathy

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11
Q

Hsv -1 is latent in which ganglia

A

Trigeminal ganglia

Causes sporadic encephalitis

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12
Q

Hsv 2 is latent in which ganglia

A

Sacral ganglia because it causes herpes genitalis

Viral meningitis is more common with hsv 2 than 1

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13
Q

What causes neonatal herpes

A

Hsv 2

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14
Q

What causes herpetic whitlow on finger

A

Hsv 1

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15
Q

What causes face mouth eye herpes temporal lobe encephalitis and esophagitis
Erythema multiforme

A

Hsv 1

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16
Q

What are herpes virus 3 4 5

A

VZV 3

EBV 4

CMV 5

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17
Q

How does ebv infecf

A

Respiratory secretions kissing disease in teens
Infects B CELLS BY Binding to CD 21
T. Cell respond forming smudge cells

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18
Q

Which drug is avoided in mononucleosis

A

Amoxicillin in mononucleosis causes maculopapular rash

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19
Q

What are manifestations of cmv

A

Mononucleosis with negative monospot test in immunocompetent

Infection in immunosuppressed
Ie cmv pneumonia in transplant, 
Esophagitis
AIDS RETINITIS- hemorrhage cotton wool exudates vision loss
Congenital cmv infection
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20
Q

Where does cmv remain latent

A

In monocytes

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21
Q

What do infected cmv cells look like

A

Owl eye intranuclear inclusion

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22
Q

Features of congenital cmv infection

A 
Hearing loss
Seizures
Petechial rash and blueberry muffin rash  
Chorioretinitis
Periventricular calcification
23
Q

How is HSV virus identified in lab

A

For skin and genitalia—- culture
For cns—- do CSF PCR
TZANKS SMEAR—- from opened skin vesicle shows multinucleated giant cell which have intranuclear eosinophilic cowdry type A inclusion/-1 to 3 hhv

24
Q

Entry receptor for CMV

A

Integrins ( heparan sulfate)

25
Q

Entry receptor for PARVOVIRUS B 19

A

P antigen on rbc

26
Q

Entry antigen for rabies virus

A

Nicotinic ACH receptor

27
Q

Entry receptor for rhinovirus

A

ICAM 1

28
Q

All RNA VIRUS replicate in cytoplasm except

A

Retrovirus HIV

Influenza virus

29
Q

Disease caused by reoviruses

A

Rota virus causes fatal diarrhoea in children

Coltivirus is an arbovirus causing colorado tick fever caused by bite of ticks

30
Q

Name various picorna virus

A

PERCH

POLIO
Echo virus - aseptic meningitis
Rhinovirus- common cold
Coxsackie - aseptic meningitis hand foot mouth synd, herpangina- fever with mouth blisters, heart—/ pericarditis and myocarditis

HAV - acute viral hepatitis

31
Q

Name the genuses of hepatitis viruses

A

HAV PICORNA - rna
HBV HEPADNA—- dna
HCV - flavivirus - rna

HDV DELTA VIRUS - rna

32
Q

Diseases caused by flaviviruses

A 
HCV
YELLOW FEVER DENGUE
ZIKA
WEST NILE ENCEPHALITIS
ST LOUIS ENCEPHALITIS
33
Q

Diseases caused by toga viruses

A

CREW

CHIKUN GUNYA WHICH IS A CO INFECTION WITH DENGUE

Rubella
Eastern and western equine encephalitis

34
Q

Disease by paramyxovirus

A

Parainfluenza - croup
RSV - bronchiolitis in babies
Mumps measles

35
Q

Diseases caused by filovirus

A

Ebola
Marburg haemorrhagic fever
Both are fatal

36
Q

Name the segmented viruses

A

All are RNA viruses
BARO

bunya— hanta virus haemorrhagic- 3 segments
Arena - lasss fever/ LCMV- 2 segments

Reo —rota colti- 10 to 12 segments
Orthomyxo- influenza - 8 segments

37
Q

Yellow fever is transmitted by

A

Aedes mosquito bite transmits yellow fever virus which is a flavivirus

38
Q

Features of yellow fever

A

High fever
Black vomitus
Jaundice and severe hepatitis

39
Q

Features of hepatitis in yellow fevef

A

Mid zone hepatic necrosis
Dying hepatocyte condense into eosinophillic contracted form known as councilmans bodies

These are inclusion due to apoptosis and are non specific

40
Q

Pathomechanism of rota virus

A

Villous destruction with atrophy

Loss of potassium and reduced absorption of sodium

41
Q

Routine vaccination of rota virus is not given in which children?

A

One with intusucceptiion

Scid disease

42
Q

What is antigenic shift

A

Sudden severe pandemics
Due to REASSORTMENT OF VIRAL GENOME SEGMENTS

BTN HUMAN INFLUENZA A AND SWINE FLU A VIRUS

43
Q

Antigenic drift

A

Drifts are gradual minor changes based on mutations in hemagglutinin and neuraminidase genes

Causes epidemics

44
Q

Congenital rubella

A

Blueberry muffin appearence due to dermal extramedullary hemopoeisis

45
Q

A premature infant is given this drug as prophylaxis to prevent RSV PNEUMONIA

A

Palivizumab- monoclonal antibody against F protein of paramyxovirus- RSV VIRUS

46
Q

Acute laryngotracheobronchitis sign on xray

A

Steeple sign

47
Q

Features of croup

A

Acute LTB causes of parainfluenza

Barking cough with inspiratory stridor and hence obstruction likely can cause pulsus paradoxus

48
Q

Lymph node biopsy in measles

A

Lymphadenitis with paracortical hyperplasia

Having fused lymphocytes—- warthin finked ley giant cells

49
Q

Effects of mumps virus

A

Parotitis
Orchitis - sterility after puberty
Pancreatitis
Aseptic meningitis

50
Q

Route of transmission of rabies

A

Bat racoon skunk bites
Dog bites if not in usa
Bat caves aerosol

51
Q

Travel of rabies virus in body

A

Entry into neurons by acetyl choline receptors
Travels retrograde in axons using dynein motor tubules
Reaches cerebellum purkinje cells and hippocampus in temporal lobe

52
Q

What are negri bodies

A

Intracytoplasmic inclusions in rabies infection

Seen in purkinje cells of cerebellum and hippocampal neurons

53
Q

What cells ebola infect

A

Endothelial cells hence can cause haemorrhagic shock dic and death

Hepatocytes
Phagocytes

54
Q

Effects of zika

A

Adults - conjunctivitis fever itchy rash

Pregnancy- congenital microcephaly and miscarriage

Outbreaks in tropical and subtropics

Flash Facts (23 decks)

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