Immunology

Question 1

First serologic marker to rise in hepatitis b

Answer 1

hbs Ag

Question 2

Marker seen in window and resolved period of hepatitis b

Answer 2

HBc antibody Ig M type in window period and IgG type in resolved period

Also IgG protective antibody against surface antigen ie Anti HBs antibod

Question 3

Presence of anti HBS ANTIBODY SUGGESTS ?

Answer 3

Resolved infection

Or Ig G protective immunisation

Question 4

Presence of HBV DNA or HBeAg ( envelop) suggests?

Answer 4

Acute infection
Chronic infection with maintained infectivity

They are sign of active viral replication and viria hence suggests infectivity

Question 5

Test to confirm hepatitis C

Answer 5

HCV RNA

decreasing levels suggest recovery

Question 6

What is more severe HDV SUPER INFECTION OR HDV CO INFECTION

Answer 6

Hdv superinfection on hbv is more serious

Question 7

Prussian blue stain differentiates between what two causes of brown pigment in liver hepatocytes

Answer 7

Prussian blue marks iron blue

Both iron and lipofuschin are brown liver pigments
Iron in hemochromatosis is confirmed by prussian blue

Question 8

Antibody seen in ulcerative colitis and primary sclerosing cholangitis

Answer 8

P anca

Question 9

Antibody seen in primary biliary cirrhosis

Answer 9

Antimitochondrial antibody