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Virology Random facts Flashcards

1
Q

Orthomyxoviridae species…

A

Influenza

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2
Q

Paramyxoviridae species…

A

Morbillivirus:Measles
Parymyxovirus: Mumps
Parinfluenza
Pneumovirus: Human Respiratory Syncytial Virus (RSV)

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3
Q

Cause of SARS

A

Coronavirus

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4
Q

Cause of croup

A

Adenovirus, influenza, and parainfluenza

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5
Q

Outbreaks in Bone marrow transplant wards

A

Adenovirus

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6
Q

Adenovirus serotypes commonly associated with outbreaks

A

3, 7a, 7b, 14 and 19

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7
Q

Smallest DNA virus

A

Parvoviruses

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8
Q

Needs a helper virus to grow in mitotically active cells

A

Adeno associated Virus

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9
Q

Picornavirus that doesn’t replicate in GI tract

A

Rhinovirus

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10
Q

Picrornavirus species…

A

Enterovirus: polio, Coxsackievirus, Echovirus
Rhinovirus
Hepatovirus-Hepatitis A virus

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11
Q

Polyprotein made by one large open reading frame

A

Poliovirus

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12
Q

No viral enzymes required for translation of viral RNA

A

Poliovirus

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13
Q

Hand foot and mouth disease

A

Coxsackievirus group A 16

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14
Q

Cruise Ship outbreaks

A

Norwalk virus

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15
Q

Leading cause of food-borne outbreaks in US

A

Norwalk virus

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16
Q

dsRNA virus

A

Rotavirus

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17
Q

Double layer capsids

A

Rotavirus (Unique?)

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18
Q

NSP4 protein

A

Rotavirus, Cholera toxin activity

Prevents water reabsorption

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19
Q

DNA Hepatitis

A

Hepatitis B

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20
Q

Picornavirus Hepatitis

A

Hepatitis A

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21
Q

Flavivirus Hepatitis

A

Hepatitis C and G

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22
Q

Hepadnavirus Hepatitis

A

Hepatitis B

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23
Q

HBsAG

A

Hepatitis B surface Ag

Diagnositic for acute hepatitis B

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24
Q

Anti-HBs

A

Antibody to HBsAg

Diagnostic for acute hepatitis B

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25
Anti-HBc
Antibody to HBcAg in acute and chronic carriers IgM=Acute IgG=Chronic
26
Cause of hepatocellular carcinoma
Hepatitis C
27
6 Classic Childhood Exanthems
``` 1-Measles 2-Strep 3-Rubella 4-Extinct 5-Parvovirus B19 6-HHV 6 and HHV 7 ```
28
Photophobia
Measles
29
Koplik's Spots
White spots on Buccal and lower labial mucosa opposite the lower molars Measles
30
Microscopy of multinuecleated giant cells in nasopharyngeal secretions
Measles
31
Togavirus
Rubella
32
TORCHES
``` Taxoplasma Gondii Rubella Cytomegalogvirus Herpes and HIV Syphillis ```
33
Thrombocyopenic purpura-blueberrymuffin
RUBELLA | measles
34
Only infect mitotically active cells
Parvovirus B19
35
Face-slap disease
Parvovirus B19
36
Hydrops fetalis
Parvovirus crossing placenta
37
Break bone fever
Dengue fever
38
Bullet shaped
Rhabdovirus (Rabies)
39
Hydrophobia
Rabies
40
Negri Bodies
Rabies
41
Sin Nombre
North American Hantavirus with deer mouse resevoir
42
Only DNA that replicates entirely in host cytoplasm
Poxivirdiae (smallpox)
43
Lentivirinae species
HIV
44
Deltaretrovirus
Human T-lymphotropic virus
45
HIV gag gene
Matrix proteins-structural
46
HIV pol gene
Protease, RT and Intergrase
47
HIV Env gene
Surface glycoprotein
48
Tegument matrix
Herpes
49
HHV-1
Herpes simplex virus 1 Mucoepithelial cells Oral Latency in nerve ganglia
50
HHV-2
Herpes simplex virus 2 Sexual Genital Latency in nerve ganglia
51
HHV-4
Epstein Barr virus Kissing Mono and lymphoma Latency in B lymphocytes
52
HHV-5
Cytomeglovirus Congenital and Sexual transmission Mono Monocytes, neutrophils, vascular endothelial cells latency
53
HHV-6
Human herpesvirus 6 Roseola in infants Latency in T lymphocytes, monocytes and macrophages
54
HHV-8
Kaposi sarcoma associated herpesvirus Tumors Latency virus infected tumors
55
Heparin sulfate
Herpes binds to enter cell
56
VP16 tegument protein
virus encoded trasncripion activation factor used by Herpes
57
Ballooning of cells in viral culture
Herpes
58
Multinucelated giant cellls with Toluidine blue and Cowdry type A inclusions
Herpes (Tzanck Smear)
59
Gamma herpes virus
Epstein Barr Virus
60
Use complement component CR2 and CD21
Epstein Barr virus
61
Atypical Lymphocytes
Epstein Barr Virus
62
EBNA IgG
Lifelong marker for primary infection of Epstein Barr Virus
63
Beta Herpes virus
Cytomegalovirus
64
Owl's eye-Histopatology of lung
Cytomegalovirus
65
Rb protein
Inhibits cell entry into G1/S phase
66
P53
Induces cell cycle arrest or apoptosis
67
HPV 16 and 18
Squamous cell carcinoma of cervix
68
HPV 6 and 11
Benign cervical warts
69
E6
Binds to p53 targets degradation
70
E7
Binds to Rb prevents from inhibiting proliferation
71
Pap Smear for....
HPV- perinuclear vacuolated cytoplasm
72
EBNA 1
Maintains presence of viral genome
73
EBNA 2
Stimulates B cell proliferation
74
EBNA 3
Inactivates Rb, stimulates cell gene expression
75
Late membrane proteins
Stimulate proliferation
76
Tax gene
Activates cellular genes encoding T cell growth factors (HTLV-1)
77
Virion consists of...
Nucleic acid genome, protein capsid, spike. +/- regulatory proteins, +/- lipid envelope
78
Eclipse phase
no infectious particles
79
Latent phase
no infectious particles outside of host cell
80
Parvorvirus Replication strategy
single stranded DNA must be converted to double stranded before it can be transcribed
81
Poxvirus Replication strategy
replicate in the cytoplasm | Must encode all of the proteins needed for gene expression and replication
82
Two RNA viruses that do not replicate in cytoplasm
Orthomyxoviruses and Retroviruses

Microbiology (10 decks)

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