Viral Replicatiion Flashcards
where is viral replication studied
in vitro
what is an eclipse time period
the time after the virus has penetrated the cell but cannot be observed for hours until the first progeny of virions become visible again
true or false
the eclipse time is related to the incubation time of the virus
false – it is unrelated
true or false
eclipse time is important time where antiviral drugs can interfere with viral replication
true
what is a susceptible cell line
virus can infect but not complete the replication cycle
what is the permissive cell lines
virus can infect and complete the cycle
how would you describe the ‘growth curve’ of a virus
exponential growth
what type of virus can have attachment but no replication
susceptible cell lines
what type of virus can have attachment and replication
permissive cell lines
why is having cell/target-specific drugs important
can eliminate the chances for toxicity
what occurs during ‘attachment’ in viral replication
receptors on the viral envelope or capsid become connected to complementary receptors and coreceptors on the cell membrane expressed in susceptible cells
what are ways of viral penetration
- membrane fusion
-endocytosis
-genetic injection
what are 2 types of uncoating
complete
incomplete
where does the virus ‘dump’ or release the DNA
in the nucleus or in the cytoplasm depending on the virus
what cell component is used to move the virus in the cell
chaperons
