Viral Patho/Pharmaco

Question 1

Obligate Intracellular Parasite does what?

Answer 1

Introduces nucleic acids into the cell in a capsid with some tegument (loose proteins)

Question 2

Glycopeptides determine what?

Answer 2

Host range

Question 3

Virus’ are not?

Answer 3

Cells and have no reproductive system

Question 4

How do they survive?

Answer 4

Host processes
Disrupt cell function
Impair synthesis and predispose to infection
Lyse out or become dormant

Question 5

DNA Viruses are?

Answer 5

Small pox
Chickenpox
Herpes
Hep B
CMV
HPV

Question 6

RNA Non-retro viruses are?

Answer 6

Rabies
Polio
Influenza
Colds
Measles Mump Rubella
Hep A/C

Question 7

RNA Retroviral Viruses are?

Answer 7

HIV and HTLV (leukemia)

Question 8

Absorption/attachment of virus

Answer 8

Determines host range

Question 9

Entry

Answer 9

Penetration into the host cell

Fusion with cell membrane

Question 10

Uncoating

Answer 10

Release of the viral nucleic acids

Question 11

Replication

Answer 11

Prophage (lie dormant)

Lysogeny (replicate to lyse)

Question 12

Assembly

Answer 12

New replicated viral prepare for inclusion

New glycoproteins and structures are staged and then assembled

Question 13

Release

Answer 13

Lysis as a naked capsid virus or bud as an enveloped virus

Question 14

Acyclovir and Valacyclovir MOA

Answer 14

Acts like guanine and causes termination

Needs thymidine kinase to add first phosphate

Question 15

Valganciclovir is very good against?

Answer 15

CMV

Question 16

Famciclovir is special how?

Answer 16

GI absorption

Question 17

High Dose and IV -Cyclovirs have what ADRs

Answer 17

Myelosuppresion
Nephrotoxicity
Neuro

Question 18

Cidofovir MOA

Answer 18

Acts like cytosine and causes termination

Doesn’t need thymidine kinase

Question 19

Cidofovir activty

Answer 19

HSV, VZV, CMV

Question 20

Cidofovir ADR

Answer 20

Nephro

Bone Marrow Suppresion

Question 21

Foscarnet MOA

Answer 21

Bind DNA pol at the pyrophosphate binding site and inhibits elongation

Question 22

Foscarnet is given?

Answer 22

IV only

Question 23

Foscarnet ADRs?

Answer 23

Nephro
Neuro
Hypocalcemia

Question 24

Fomivirsen MOA

Answer 24

Gene silencing - inhibits replication

Question 25

Amatadine and Rimatadine MOA

Answer 25

Cyclic primary
Inhibit viral uncoating
Inhibit assembly

Question 26

Amatadine and Rimatadine is given?

Answer 26

PO

Question 27

Oseltamivir & Zanamivir

Answer 27

Tamiflu and Relenza
Analog of sialic acid
Inhibit neuramidase and block release of new viruses

Question 28

Oseltamivir is given?

Answer 28

PO

Question 29

Oseltamivir ADR?

Answer 29

Psychiatric

Question 30

Zanamivir is given?

Answer 30

Intranasal or inhalation

Question 31

Hep B and Hep C treatment?

Answer 31

Adefovir
Interferons
Lamivudine and Telbivudine
Ribavirin

Question 32

Adefovir MOA

Answer 32

Mimics adensosine
Acyclic
Inhibits DNA pol

Question 33

Adefovir is given?

Answer 33

PO

Question 34

High dose adefovir can cause?

Answer 34

Nephro

Question 35

Interferons MOA

Answer 35

Activate JACK-STAT and upregulate host cell proteins that affect viral production

Question 36

Interferons are given?

Answer 36

IV

Question 37

Interferons ADR

Answer 37

Myelosuppresion

CYP

Question 38

Lamivudine MOA

Answer 38

Acts like cytosine

Question 39

Telbivudine MOA

Answer 39

Acts like thymine

Question 40

Lamivudine and Telbivudine are given?

Answer 40

PO

Question 41

Ribavirin MOA

Answer 41

Tribavirin
Decrease GTP synthesis
Inhibits post-transcriptional process of viruses (capping)

Question 42

Ribavirin is given?

Answer 42

PO or IV