Anti-Retrovirals

Question 1

Didanosine

Answer 1

Given with antacids

Question 2

Stavudine

Answer 2

Lactic acidosis liver damage black box

Question 3

Abacavir

Answer 3

Nuceloside

Question 4

Tenofovir

Answer 4

Longest t1/2

NuceloTide NRTI

Question 5

NNRTI MOA

Answer 5

Noncompetively inhibit RT at a distant site via conformation cahnge and reduce catalytic activity

Question 6

NNRT ADR

Answer 6

CNS- nightmares, psychosis

Question 7

What to NNRTI’s are both inducers and inhibitors of 3A4?

Answer 7

Efavirenz

Nevirapine

Question 8

PI MOA

Answer 8

Block cleave of protease

Question 9

PI that is a transition state analog?

Answer 9

Sequinavir

Question 10

Worst PI

Answer 10

Nelfinavir with a lower genetic barrier

Question 11

PI for pregnancy

Answer 11

Lopinavir

Question 12

PI with less lipodystrophy and endocrine problems

Answer 12

Atazanavir

Question 13

Ritonavir booster does what

Answer 13

Inhibits 3A4 and P-gp –> decreasing clearance and increase bioavailability

Question 14

Fusion Inhibitors MOA

Answer 14

Bings gp41 preventing membrane fusion

Question 15

Fusion Inhibitor Drugs

Answer 15

Enfuvirtide

Fuzeon

Question 16

What integrase STI is boosted with colistin?

Answer 16

Elvitegravir

Question 17

ISTI drugs

Answer 17

Raltegravir

Elvitegravir

Question 18

CXCR4 is more common on?

Answer 18

T cells

Question 19

CCR5 is more common on?

Answer 19

macrophages

Question 20

CCR5 drug

Answer 20

Maraviroc (Selzentry)