Parasitic Infection Miller Flashcards
1
Q
Class 1 agents act against?
A
Asexual RBC forms
Merozoites, trophozoites, and RBC-schizonts
2
Q
Class II agents act against?
A
RBC forms
Primary liver stage of falciparum
3
Q
Class III agent act against?
A
Primaquine (G6PD)
Liver Schizonts and Hypnozoite
Gametocytes
4
Q
Quinolines MOA
A
Binds heme as it is released
Interferes with heme metabolism and handling
5
Q
Quinolines ADME and ADR
A
CV
CNS
G6PD!!!!!
Hepatic and Renal excretion
6
Q
Pyrimethamine and Sulfadoxine MOA
A
DHFR, thymidylate synthase and dihydropteroate synthase (decrease synthesis and assembly)
7
Q
Atovaquone and Proguanil MOA
A
“Malarone”
A: inhibits electron transport and decrease ATP
P: DHFR/Thymidylate Synthetase
8
Q
Malarone ADR
A
ALT AST elevation
