Abx in Systemic Fungal Infections Flashcards
Fungi are what, with what, can produce what?
Eukaryotic
Rigid cell wall composed of chitin (B1,3-D-Glucan) which doesn’t stain
Ergosterol instead of cholesterol
Can produce Spores
Yeast are?
Unicellular
Pathogenic- Invades the hose
Molds are?
Multicellular with branching
Free-living within the environment
Asexual form is called?
Cryptococcus
Infectious form is called?
Filobasidiella
Three most common species of systemic infection?
Candida
Cryptococcus
Aspergillus
Amphotericin B MOA
Binds to membrane via ergosterol and forms pores
Amphotericin B ADME
IV only
Hepatic Excretion
Can cause development of renal problems
Amphotericin B ADR
Nephro
Decrease K and Mg
Amphotericin B Spectrum
Fungal and Aspergillis
Flucytosine (5-FC) MOA
Resembles Cytosine
5-FUTP disrupts RNA and protein synthesis
5-FdUMP inhibits thymidylate synthetase (DNA)
5-FC Spectrum
Yeast (Cryptococcus and Candida)
5-FC ADME
Synergistic with Amp B
CSF
5-FC ADR
Bone marrow Suppression
Hepatic dysfunction
Imidazoles
2 Nitrogens
Triazoles
3 Nitrogens
Fluconazole, itraconazole, vori, posa
Preferred
Azoles MOA
Block P450 dependent synthesis of Ergosterol
Lanosterol -X-> Ergosterol
Azoles Human Actions
Inhibit gonadal and adrenal steroid synthesis (decreased testosterone)
Azole Spectrum
Candida
Crypto
Aspergillus
Fluconazole target? Other?
Crypto
Coccidio
Renal
CNS
Voriconazole target?
Aspergillus
CNS
Food decreases absorption
Posaconazole target?
Zygomycetes
Little cyp
Oral only
Azole ADR
CV
Hepato
Visual/Hallucinations
Echinocandins MOA
Inhibit B(1,3)-D-glucan (cell wall component)
