Viral menigitis and poliomyelitis Flashcards
بسم الله الرحمن الرحيم
وهو علي كل شئ قدير
___________________
aseptic meingits mean ?
Mengigeal inflammation with sterile CSF without bacteria
Most common form of meneigits is,,,,,,,
Except chidlern younger than 10 years the ,,,,,, is more
Midle than bacterial and funal menigits
causes Skin rashes ,sore thorats and colds
VIRAL
BACTERIAL
Symptoms of menigitis
=Fever
=Altered consicusness irritability photophobia
=Seizure
=Bugling fonatnels
=Stiff neck or nuchal rigidity
=Meningisumus (stiff neck + Brudzinski and Kernig signs )
The most commoc causes of viral menigitis ?
Enteroviruses ( coxasackie and echovirus )
_________________
less commn :
HSV
VZV
CMV
2M Mumpes measels
West Nile virus HIV
HEPRS SIMPLEX TYPE2
Enceloped
duble stranded DNA virus
transmitted sexully
semin and vaginal discharge
from mother to fetus
_______________________
VZV
Enveloped Double stranded DNA VIRUS
Tranismitted by droplets of resp secretion
contact with vesicular fluid of rash in chicken pox or zoster
Mumps
Enveloped single stranded RNA
Droplets and Saliva
west nile virus
arbovirus
enveloped Single stranded RNA virus transmitted by?
arthtopds vector
HIV
enveloped RNA Virus
can be transmitted through blood and blood product
ans seexual process
Enteroviruses belongs to ,,,,,,,
4 sub groups
PCEN
Non enevloped single stranded +snese RNA virus with icosahedral symmetrty
Unllikde rhinovirsues they are ?
Enter through ?>
PicoRnaVirdiae
Polioviruses
Coxsackiviruses
Echovirsues
Newer enteroviruses
_-______________——-
HCL acid stable
GIT
what are enetrovirus mode of tramsnossion
Aerosol inhalation
ingestion then to orophaynx replicating to reach peyers pathces then to blood
primary viremia
secondary viremia
then to CNS tropism
and tropism to other systems
pleurosy myocarditis skin rash other !
Non polio enteroviruse mor common in ,,,, and,,,,,,,
Spread
1-
2-
3-
4-
The only ressvoir is ?
Respiratory aerosols plays a role in ,,,,,, virus transmission
summer and fall
person to person
House flies
waste water and sweage
fecal oral transmisson
Human
Coxacike virus
________
tip:rhino virus die in gastric acidity
90 most aseptic menigitis by?
Group B coxackie virus
Echoviruses
Diagnosis of meniegit by?
Lumbar puncture
for CSF analysis
supranant
normal protien glucose and pressurre but high lymphocyte this is viral etiology
specific method for promet diagnosius of viral menigits
PCR
Reverse trancriptase PCR
LAB DIAGNOIIS OF VIRAL MENIGITS
CSF evaluation
___________________
PCR
________________________
Virus isolation
Serology
Neutaliztion tests or EIA are used
__________________________
How to prevent viral menigits ?
no antiviral due to muilplicity of serotypes
_______________________________
GOOD HYGIENE PRACATICE
Clean hands
claean surfaces
coveing cough
avoid kissing or sharing glass or items of eating
Viral menigits dagner?
less fulminant than bacterial menigits
but in infants <1 years causes speech and language delay
Polioviruses has serotypes accoirding to outer ,,,,proteins
1-3
Reaction to physical and chemical agents inactivated by?
1-
2-
3-
)))))))))))))))
enteroviruses are transient inhibtants of human alimnetary tracts they are acid .,,,,,,,,? can be isolated from ,,,,oir,,,,,,,,
all are traenimistted by ? and frow at ?
capsid
1-heating
2-pasteruiztaton
3-cholorination
__________________
stable
Throat or lower intestin
Feco oral transmisson at 36-37 degress
Purely neurotropic virus
Poliomyelits
Polio
natural cases ocuuri only in man
source from ,,,and,,,cases
incubation =
apparent and subclinical patients
____________________
7-14 days
3-35 day
abortive poliomyelitis
the immune system succeed in aboring poilio infecton of CNS
by netraulizing antibodeis aborting it once entering the Blood from intesitn peyrs patches
If in rare cases poliovirus reached Blood what happen
spread thorugh perihperal nerves to the anterior horn cells of spinal cord leading to paralytic poliomyelitis
__________________
Poliovirus and tonsillectomy
The poliovirus after tonsillectomy spread thorugh cut nerve fibers of orophayenx then to CNS
