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A-CNS MICRO > Viral menigitis and poliomyelitis > Flashcards

Viral menigitis and poliomyelitis Flashcards

1
Q

بسم الله الرحمن الرحيم
وهو علي كل شئ قدير
___________________
aseptic meingits mean ?

A

Mengigeal inflammation with sterile CSF without bacteria

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2
Q

Most common form of meneigits is,,,,,,,
Except chidlern younger than 10 years the ,,,,,, is more
Midle than bacterial and funal menigits
causes Skin rashes ,sore thorats and colds

A

VIRAL
BACTERIAL

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3
Q

Symptoms of menigitis

A

=Fever
=Altered consicusness irritability photophobia
=Seizure
=Bugling fonatnels
=Stiff neck or nuchal rigidity
=Meningisumus (stiff neck + Brudzinski and Kernig signs )

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4
Q

The most commoc causes of viral menigitis ?

A

Enteroviruses ( coxasackie and echovirus )
_________________
less commn :
HSV
VZV
CMV
2M Mumpes measels
West Nile virus HIV

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5
Q

HEPRS SIMPLEX TYPE2

A

Enceloped
duble stranded DNA virus
transmitted sexully
semin and vaginal discharge
from mother to fetus
_______________________

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6
Q

VZV

A

Enveloped Double stranded DNA VIRUS
Tranismitted by droplets of resp secretion
contact with vesicular fluid of rash in chicken pox or zoster

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7
Q

Mumps

A

Enveloped single stranded RNA
Droplets and Saliva

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8
Q

west nile virus

A

arbovirus
enveloped Single stranded RNA virus transmitted by?
arthtopds vector

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9
Q

HIV

A

enveloped RNA Virus
can be transmitted through blood and blood product
ans seexual process

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10
Q

Enteroviruses belongs to ,,,,,,,
4 sub groups
PCEN
Non enevloped single stranded +snese RNA virus with icosahedral symmetrty
Unllikde rhinovirsues they are ?
Enter through ?>

A

PicoRnaVirdiae
Polioviruses
Coxsackiviruses
Echovirsues
Newer enteroviruses

_-______________——-
HCL acid stable
GIT

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11
Q

what are enetrovirus mode of tramsnossion

A

Aerosol inhalation
ingestion then to orophaynx replicating to reach peyers pathces then to blood
primary viremia
secondary viremia
then to CNS tropism
and tropism to other systems
pleurosy myocarditis skin rash other !

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12
Q

Non polio enteroviruse mor common in ,,,, and,,,,,,,
Spread
1-
2-
3-
4-
The only ressvoir is ?
Respiratory aerosols plays a role in ,,,,,, virus transmission

A

summer and fall
person to person
House flies
waste water and sweage
fecal oral transmisson
Human
Coxacike virus
________
tip:rhino virus die in gastric acidity

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13
Q

90 most aseptic menigitis by?

A

Group B coxackie virus
Echoviruses

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14
Q

Diagnosis of meniegit by?

A

Lumbar puncture
for CSF analysis
supranant
normal protien glucose and pressurre but high lymphocyte this is viral etiology

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15
Q

specific method for promet diagnosius of viral menigits

A

PCR
Reverse trancriptase PCR

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16
Q

LAB DIAGNOIIS OF VIRAL MENIGITS

A

CSF evaluation
___________________
PCR
________________________
Virus isolation
Serology
Neutaliztion tests or EIA are used
__________________________

17
Q

How to prevent viral menigits ?

A

no antiviral due to muilplicity of serotypes
_______________________________
GOOD HYGIENE PRACATICE
Clean hands
claean surfaces
coveing cough
avoid kissing or sharing glass or items of eating

18
Q

Viral menigits dagner?

A

less fulminant than bacterial menigits
but in infants <1 years causes speech and language delay

19
Q

Polioviruses has serotypes accoirding to outer ,,,,proteins
1-3
Reaction to physical and chemical agents inactivated by?
1-
2-
3-
)))))))))))))))
enteroviruses are transient inhibtants of human alimnetary tracts they are acid .,,,,,,,,? can be isolated from ,,,,oir,,,,,,,,
all are traenimistted by ? and frow at ?

A

capsid
1-heating
2-pasteruiztaton
3-cholorination
__________________
stable
Throat or lower intestin
Feco oral transmisson at 36-37 degress

20
Q

Purely neurotropic virus

A

Poliomyelits

21
Q

Polio
natural cases ocuuri only in man
source from ,,,and,,,cases
incubation =

A

apparent and subclinical patients
____________________
7-14 days
3-35 day

22
Q

abortive poliomyelitis

A

the immune system succeed in aboring poilio infecton of CNS
by netraulizing antibodeis aborting it once entering the Blood from intesitn peyrs patches

23
Q

If in rare cases poliovirus reached Blood what happen

A

spread thorugh perihperal nerves to the anterior horn cells of spinal cord leading to paralytic poliomyelitis
__________________

24
Q

Poliovirus and tonsillectomy

A

The poliovirus after tonsillectomy spread thorugh cut nerve fibers of orophayenx then to CNS

25
Q

Steps of pathogenisis of Polioviruses

A

1-Alimentary phase
2-Lymphatic phase
3-Viremic phase if no abortive poliomyeltis
4-Neurological phase

26
Q

Clinical findings of poliomyelitis

A

Asymtomatic
Abortive poliomyelits
with fever heache nasuse vomiting constipation
Non paralytic poliomyelitis
paralytic poliomyelits

27
Q

Laboratory diagnosis of polioviruses

A

Isolation of virus by throat swab or rectal swab
__________________________
Seology L
Rising titre in ELISA+ Neutralization test
___________
no antiviral + symptomatic treatment + resp support

28
Q

prevnetion of Poloivirsurs

A

1-avoid fecoral contamination
2-avoid operation in feverish childs
3-Gamma globulins protect agains paralytic disease befroe infection or before Nervous lesion
4-Vaccines

29
Q

Vaccines of poliomyelits

A

Oral poliovaccine live attenuated 3 serotypes most effective due to IgA IgG IgM
Inactivated polio vaccine IPV 3 formalin killed polio serotypes

30
Q

Sabin vaccine is ?
Iive attenuated ,,,,,,,,,,,, stabilized
containing ,,,,,,,,,,,,,,,,,,,,,grown in human or monkey diploid cell cultures . it can be kept at 4c for a year
aminstered easily by,,,,,,,,,,,,

Mass vaccination how ?
Live attenutaed virus shed in stool of immunized children so person exposed to ,,,,,,,,,,,,,,,,,,,,,,, of vaccinated children may be exposed and infected with live attenuated vaaccine cuasing?

A

Magnusim choloride
3 poliovirus strains
oral droplets
____________________
Fecal material
Herd immunity
______________
tips :
higly effecitve eliciting immunity to polios
50 immunity after 1 dose
95 immunity after 3 doses
Immunity probably life lonog

31
Q

Mention advantages of OPV

A

HLPE2
eFfictevenss
Life long with no need to boosters mostly
Eliciting Local immunity IgA and systemic immunity by IgG
Ease of adminstraion
Possibility of attenuated virus cirulating in community by spread to contacts indirect immunizatioon or Herd Immunity

32
Q

Disafvantage of OPV ?

A

BMP
Mutation into More virulent strain
______________________________
Blocked if another enterovirus invading cells
____________________
trasnmitted to others with mutation !
____________________
Associated poilomyeleitis if Mutated

33
Q

Mention advanatges of IPV

A

-Cannot undergo genetic -virulence -so no associated diesease
-Saftery transport and storage
-safety adminsterd in immunodefecits

34
Q

Mention disavnatege of IPV

A

Lack of local gut immunity
Expensive painful parentral IM injection
Less antigenicity
Need Booster
l2en

35
Q

الحمدلله رب العالمين

A

A-CNS MICRO (7 decks)

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