Rabies ! ( 27/11) Flashcards
بسم الله الرحمن الرحيم
“قل الحمدلله وسلام علي عباده الذين اصطفي”
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Rabies is ,,,,,,,virus belonging to ,,,,,?
Neurotropic virus
Rhabdoviridae
Rabies is lethal form of …….
a broad host range can infect,,,,,,,?
Acute encephalitis
_____________
all mamals
Rabies is lethal form of …….
a broad host range can infect,,,,,,,?
Acute encephalitis
_____________
all mammals
zoonotic acquired accidently by humans
Rabies Resvior ?
Mode of Transmisson ?
All mamals
By bite of rabid animal espicallly street Dogs
Mention mode of Transsimisson of Rabies
=Bite from rabied animal
=Aerosol secretions of rabid animal
=Conreal Tranplanation from rabid cadave
Pathogenesis of Rabies
After a bite of infected animal
the saliva containing the Rabies virus reaches the muscle then virus reaches
- NMJ then retrograde transmitted to DRG replicating their then
-Through spinal cord to brain causing brain damage!
then Through sensory nerves to?
Cornea = tranplantation infection
Salivaryglands = bite infection
Clincal picture of rabies
I.P =2-16 Weeks
is shorter if bitten at neck and head
phases of Rabies
Prodromal
Furious
Paralytic phases
Describe prodromal phase of rabies
Parasthesia around the wound
Headache anorexia Fever
DESCTIBE FURIOS AND PARALTIC RABIES
Furios:
Brain is inovlved
Excitement SEIZURE
Delerium
Hydrophobia
Hyper reflexia
DESCTIBE FURIOS AND PARALTIC RABIES
Furios:
Brain is inovlved
Excitement SEIZURE
Delerium
Hydrophobia
Hyper reflexia
___________________
Hydrophobia due to spam of pharyngeal muscles
________________________
Paralytic PHase:
Ascending paralyis due to spinal cord affection
____________________
If not post exposure prophylacted from rabies?
Death waits you !
How is rabies diagnosed
Direct demonstration in
Saliva
CSF
Skin biopsy
+
DIF OR RT-PCR
_______________________________
Serolgoy no viremia so it is late!!
serum and CSF van be deteccted during late diseae progression
IIF Nt test
Viral isolation in rabies
In urin saliva CSF
Intracerebrally in suckling mice or
Human diploid cell culture
Brain tissue of the dead animal is examined for?in rabies
Negri bodies
Viral antigen
Negri bodies
Intracytoplasmic inclusions
eosiomphilic
=Rabies
in brain and nervous tissue
Postmortum diagnostic tool under L/M EXAMINATION IN BRAIN AND SPINAL CORD
Postmortum diagnostic tool
Negri bodie in brain and spinal cord
What is the mangemetn of Rabies ?
1-SOAP + WATER FOR 10 MINUTES
2-Tetanus
3-PEP:
Not vaccinated before : Human rabies Igs half in bite half in gluteal + 5 doses of vaccine 0 3 7 14 28
vaccinated within 5 years : 2 doses only of the vaccine
From what is rabies vaccnie formed ?
From Inactivated Rabies Virus
grwon on tissue culture
Human diploid ceel
Monkey cell
duck embryo
Gold standard for rabies vaccination ?
Human diploid cell vaccine
Pre-epxosure vaccination is given to ?
1=Highly risk individuals as veterinary doctors.
2=Travelers !
Pre-epxosure vaccination is given to ?
1=Highly risk individuals as veterinary doctors.
2=Travelers !
5 Doses IM in deltoid
Prevention of rabies HOW?
1-Elimination of the source ( Vacinnate domestics - Eliminate stray ! )
2-Pre&post exposure prophylaxix
Post infectious encephalitis is >?
Milder from of encephlats follwing
Infection OR
Immunization after several weeks attacking brain CNS antigens
casuing demyleination
Gullian Barre syndrome caused by?
HIV
CMV
EBV
hce
Reye’s syndrome=
Salicylate +
Inflenza B
VZV
Adenoviruses
Childhood viruses impilcated in post infection encephlaitis ?
MMR
Mesels Mumps Rubella
VZV
Tropical spsatic parapareis caused by?
Human lymphotropic virus 1
HTLV-1
IN Transvers Myelitis
Describe Human lymphotropic virus 1 induced Transvers Myelitis .
=A demyliniating diseas of neurons of brain and motor neuron of spinal cord due to ?
-Autoimmune corss reaction attacking the diseasd nerons
-Cytotoxic T cells kills Neurons affected !
SLOW CNS INFECTIONS CAUSED BY?
MEASLES
JC VIRUS
PRIONS
PML
Progressive multifocal leukoencephalopathy
caused by?
occurs in immuno compromised
JC VIRUS Opportunistic virus
How to diagnose JC Virus?
PCR FOR Viral DNA in CSF
NOT antiviral no Thearpy!
Misofolded protein causing SLOW CNS INFECTION
=PRIONS
Cuasing
Kuru &
Variant Cretuzfeldt jakob disease (vCJD )
Mode of Transmisson of Kuru
and Variant creuzfeldt jakob disease?
Ingestion of Prion contaitng beefs
Conreal Tranplantation
Dura transplatation from infected cadavar
Prions cause ?
Progressive brain danage!
misfolded protein inducing froming misfolded protein accumulating near the Nerve compressing its blood supply casuing its degenartion and Spongiform histological change.
Clincal presentaiton of PRIONS DISEASE
Gradual onset!
Progressive dementia
Myoclonus
Coma+death
Lab diagnosis of prions diseases
1-Postmortum bipsy from CNS
showing spongiform histological change in the nerves
2-No serological test no immunity forms against it
3-prions cannot be grown on culture
Prevention from prion diseases?
Infected animals Slaughtered!
Carcasses destroyed !
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No available treatment or Vaccine
الحمدلله رب العالمين
