Rabies ! ( 27/11)

Question 1

بسم الله الرحمن الرحيم
“قل الحمدلله وسلام علي عباده الذين اصطفي”
_________________________________
Rabies is ,,,,,,,virus belonging to ,,,,,?

Answer 1

Neurotropic virus
Rhabdoviridae

Question 2

Rabies is lethal form of …….
a broad host range can infect,,,,,,,?

Answer 2

Acute encephalitis
_____________
all mamals

Question 3

Rabies is lethal form of …….
a broad host range can infect,,,,,,,?

Answer 3

Acute encephalitis
_____________
all mammals
zoonotic acquired accidently by humans

Question 4

Rabies Resvior ?
Mode of Transmisson ?

Answer 4

All mamals
By bite of rabid animal espicallly street Dogs

Question 5

Mention mode of Transsimisson of Rabies

Answer 5

=Bite from rabied animal
=Aerosol secretions of rabid animal
=Conreal Tranplanation from rabid cadave

Question 6

Pathogenesis of Rabies

Answer 6

After a bite of infected animal
the saliva containing the Rabies virus reaches the muscle then virus reaches
- NMJ then retrograde transmitted to DRG replicating their then
-Through spinal cord to brain causing brain damage!
then Through sensory nerves to?
Cornea = tranplantation infection
Salivaryglands = bite infection

Question 7

Clincal picture of rabies

Answer 7

I.P =2-16 Weeks
is shorter if bitten at neck and head

Question 8

phases of Rabies

Answer 8

Prodromal
Furious
Paralytic phases

Question 9

Describe prodromal phase of rabies

Answer 9

Parasthesia around the wound
Headache anorexia Fever

Question 10

DESCTIBE FURIOS AND PARALTIC RABIES

Answer 10

Furios:
Brain is inovlved
Excitement SEIZURE
Delerium
Hydrophobia
Hyper reflexia

Question 11

DESCTIBE FURIOS AND PARALTIC RABIES

Answer 11

Furios:
Brain is inovlved
Excitement SEIZURE
Delerium
Hydrophobia
Hyper reflexia
___________________
Hydrophobia due to spam of pharyngeal muscles
________________________
Paralytic PHase:
Ascending paralyis due to spinal cord affection
____________________

Question 12

If not post exposure prophylacted from rabies?

Answer 12

Death waits you !

Question 13

How is rabies diagnosed

Answer 13

Direct demonstration in
Saliva
CSF
Skin biopsy
+
DIF OR RT-PCR
_______________________________
Serolgoy no viremia so it is late!!
serum and CSF van be deteccted during late diseae progression
IIF Nt test

Question 14

Viral isolation in rabies

Answer 14

In urin saliva CSF
Intracerebrally in suckling mice or
Human diploid cell culture

Question 15

Brain tissue of the dead animal is examined for?in rabies

Answer 15

Negri bodies
Viral antigen

Question 16

Negri bodies

Answer 16

Intracytoplasmic inclusions
eosiomphilic
=Rabies
in brain and nervous tissue
Postmortum diagnostic tool under L/M EXAMINATION IN BRAIN AND SPINAL CORD

Question 17

Postmortum diagnostic tool

Answer 17

Negri bodie in brain and spinal cord

Question 18

What is the mangemetn of Rabies ?

Answer 18

1-SOAP + WATER FOR 10 MINUTES
2-Tetanus
3-PEP:
Not vaccinated before : Human rabies Igs half in bite half in gluteal + 5 doses of vaccine 0 3 7 14 28
vaccinated within 5 years : 2 doses only of the vaccine

Question 19

From what is rabies vaccnie formed ?

Answer 19

From Inactivated Rabies Virus
grwon on tissue culture
Human diploid ceel
Monkey cell
duck embryo

Question 20

Gold standard for rabies vaccination ?

Answer 20

Human diploid cell vaccine

Question 21

Pre-epxosure vaccination is given to ?

Answer 21

1=Highly risk individuals as veterinary doctors.
2=Travelers !

Question 22

Pre-epxosure vaccination is given to ?

Answer 22

1=Highly risk individuals as veterinary doctors.
2=Travelers !
5 Doses IM in deltoid

Question 23

Prevention of rabies HOW?

Answer 23

1-Elimination of the source ( Vacinnate domestics - Eliminate stray ! )
2-Pre&post exposure prophylaxix

Question 24

Post infectious encephalitis is >?

Answer 24

Milder from of encephlats follwing
Infection OR
Immunization after several weeks attacking brain CNS antigens
casuing demyleination

Question 25

Gullian Barre syndrome caused by?

Answer 25

HIV
CMV
EBV
hce

Question 26

Reye’s syndrome=

Answer 26

Salicylate +
Inflenza B
VZV
Adenoviruses

Question 27

Childhood viruses impilcated in post infection encephlaitis ?

Answer 27

MMR
Mesels Mumps Rubella
VZV

Question 28

Tropical spsatic parapareis caused by?

Answer 28

Human lymphotropic virus 1
HTLV-1
IN Transvers Myelitis

Question 29

Describe Human lymphotropic virus 1 induced Transvers Myelitis .

Answer 29

=A demyliniating diseas of neurons of brain and motor neuron of spinal cord due to ?
-Autoimmune corss reaction attacking the diseasd nerons
-Cytotoxic T cells kills Neurons affected !

Question 30

SLOW CNS INFECTIONS CAUSED BY?

Answer 30

MEASLES
JC VIRUS
PRIONS

Question 31

PML
Progressive multifocal leukoencephalopathy
caused by?
occurs in immuno compromised

Answer 31

JC VIRUS Opportunistic virus

Question 32

How to diagnose JC Virus?

Answer 32

PCR FOR Viral DNA in CSF
NOT antiviral no Thearpy!

Question 33

Misofolded protein causing SLOW CNS INFECTION

Answer 33

=PRIONS
Cuasing
Kuru &
Variant Cretuzfeldt jakob disease (vCJD )

Question 34

Mode of Transmisson of Kuru
and Variant creuzfeldt jakob disease?

Answer 34

Ingestion of Prion contaitng beefs
Conreal Tranplantation
Dura transplatation from infected cadavar

Question 35

Prions cause ?

Answer 35

Progressive brain danage!
misfolded protein inducing froming misfolded protein accumulating near the Nerve compressing its blood supply casuing its degenartion and Spongiform histological change.

Question 36

Clincal presentaiton of PRIONS DISEASE

Answer 36

Gradual onset!
Progressive dementia
Myoclonus
Coma+death

Question 37

Lab diagnosis of prions diseases

Answer 37

1-Postmortum bipsy from CNS
showing spongiform histological change in the nerves
2-No serological test no immunity forms against it
3-prions cannot be grown on culture

Question 38

Prevention from prion diseases?

Answer 38

Infected animals Slaughtered!
Carcasses destroyed !
_________________________
No available treatment or Vaccine

Question 39

الحمدلله رب العالمين