Rabies ! ( 27/11) Flashcards by Omar Gazar

بسم الله الرحمن الرحيم
“قل الحمدلله وسلام علي عباده الذين اصطفي”
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Rabies is ,,,,,,,virus belonging to ,,,,,?

Neurotropic virus
Rhabdoviridae

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Rabies is lethal form of …….
a broad host range can infect,,,,,,,?

Acute encephalitis
_____________
all mamals

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Rabies is lethal form of …….
a broad host range can infect,,,,,,,?

Acute encephalitis
_____________
all mammals
zoonotic acquired accidently by humans

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Rabies Resvior ?
Mode of Transmisson ?

All mamals
By bite of rabid animal espicallly street Dogs

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Mention mode of Transsimisson of Rabies

=Bite from rabied animal
=Aerosol secretions of rabid animal
=Conreal Tranplanation from rabid cadave

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Pathogenesis of Rabies

After a bite of infected animal
the saliva containing the Rabies virus reaches the muscle then virus reaches
- NMJ then retrograde transmitted to DRG replicating their then
-Through spinal cord to brain causing brain damage!
then Through sensory nerves to?
Cornea = tranplantation infection
Salivaryglands = bite infection

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Clincal picture of rabies

I.P =2-16 Weeks
is shorter if bitten at neck and head

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phases of Rabies

Prodromal
Furious
Paralytic phases

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Describe prodromal phase of rabies

Parasthesia around the wound
Headache anorexia Fever

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DESCTIBE FURIOS AND PARALTIC RABIES

Furios:
Brain is inovlved
Excitement SEIZURE
Delerium
Hydrophobia
Hyper reflexia

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DESCTIBE FURIOS AND PARALTIC RABIES

Furios:
Brain is inovlved
Excitement SEIZURE
Delerium
Hydrophobia
Hyper reflexia
___________________
Hydrophobia due to spam of pharyngeal muscles
________________________
Paralytic PHase:
Ascending paralyis due to spinal cord affection
____________________

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If not post exposure prophylacted from rabies?

Death waits you !

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How is rabies diagnosed

Direct demonstration in
Saliva
CSF
Skin biopsy
+
DIF OR RT-PCR
_______________________________
Serolgoy no viremia so it is late!!
serum and CSF van be deteccted during late diseae progression
IIF Nt test

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Viral isolation in rabies

In urin saliva CSF
Intracerebrally in suckling mice or
Human diploid cell culture

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Brain tissue of the dead animal is examined for?in rabies

Negri bodies
Viral antigen

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Negri bodies

Intracytoplasmic inclusions
eosiomphilic
=Rabies
in brain and nervous tissue
Postmortum diagnostic tool under L/M EXAMINATION IN BRAIN AND SPINAL CORD

Postmortum diagnostic tool

Negri bodie in brain and spinal cord

What is the mangemetn of Rabies ?

1-SOAP + WATER FOR 10 MINUTES
2-Tetanus
3-PEP:
Not vaccinated before : Human rabies Igs half in bite half in gluteal + 5 doses of vaccine 0 3 7 14 28
vaccinated within 5 years : 2 doses only of the vaccine

From what is rabies vaccnie formed ?

From Inactivated Rabies Virus
grwon on tissue culture
Human diploid ceel
Monkey cell
duck embryo

Gold standard for rabies vaccination ?

Human diploid cell vaccine

Pre-epxosure vaccination is given to ?

1=Highly risk individuals as veterinary doctors.
2=Travelers !

Pre-epxosure vaccination is given to ?

1=Highly risk individuals as veterinary doctors.
2=Travelers !
5 Doses IM in deltoid

Prevention of rabies HOW?

1-Elimination of the source ( Vacinnate domestics - Eliminate stray ! )
2-Pre&post exposure prophylaxix

Post infectious encephalitis is >?

Milder from of encephlats follwing
Infection OR
Immunization after several weeks attacking brain CNS antigens
casuing demyleination

Gullian Barre syndrome caused by?

HIV CMV EBV hce

Reye's syndrome=

Salicylate + Inflenza B VZV Adenoviruses

Childhood viruses impilcated in post infection encephlaitis ?

MMR Mesels Mumps Rubella VZV

Tropical spsatic parapareis caused by?

Human lymphotropic virus 1 HTLV-1 IN Transvers Myelitis

Describe Human lymphotropic virus 1 induced Transvers Myelitis .

=A demyliniating diseas of neurons of brain and motor neuron of spinal cord due to ? -Autoimmune corss reaction attacking the diseasd nerons -Cytotoxic T cells kills Neurons affected !

SLOW CNS INFECTIONS CAUSED BY?

MEASLES JC VIRUS PRIONS

PML Progressive multifocal leukoencephalopathy caused by? occurs in immuno compromised

JC VIRUS Opportunistic virus

How to diagnose JC Virus?

PCR FOR Viral DNA in CSF NOT antiviral no Thearpy!

Misofolded protein causing SLOW CNS INFECTION

=PRIONS Cuasing Kuru & Variant Cretuzfeldt jakob disease (vCJD )

Mode of Transmisson of Kuru and Variant creuzfeldt jakob disease?

Ingestion of Prion contaitng beefs Conreal Tranplantation Dura transplatation from infected cadavar

Prions cause ?

Progressive brain danage! misfolded protein inducing froming misfolded protein accumulating near the Nerve compressing its blood supply casuing its degenartion and Spongiform histological change.

Clincal presentaiton of PRIONS DISEASE

Gradual onset! Progressive dementia Myoclonus Coma+death

Lab diagnosis of prions diseases

1-Postmortum bipsy from CNS showing spongiform histological change in the nerves 2-No serological test no immunity forms against it 3-prions cannot be grown on culture

Prevention from prion diseases?

Infected animals Slaughtered! Carcasses destroyed ! _________________________ No available treatment or Vaccine

الحمدلله رب العالمين