Bacterial meningitis Flashcards
بسم الله الرحمن الرحيم وبه نستعين
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infections affectin muscle tone
C,tentai spastic
c,botulinum flaccid parlaysis
Mention bacteria casuing meneingitis
NHS PAL
Nessiria menigitidis
Hemoplilus infulucnazer
Sterptococcus pnemoniae and aglagctae
Listera monocytogens
Mention Modes of infectos of meniegitis
PDLH
=Peripheral nerves as rabis + herpes zoster
=Direct implanatation iatrogenic as lumbar puncture
=Local extension from skull and spine
=Hematogenous spread :-
By arterial blood supply and Connections between facial veins and Venous sinuses
Classify meiengitis
According to speed of intial presentation and speed of progerssion :
Acute from hours to days and by pyogenics as S,penumoniae + Neissiera mengitifdis
Subacute from days to few weeks and by CM? fungal cryptococcus and Mycobacterium tuberclosis
Chronic reaching 4 weeks by
Complications of mentioned above or
Viral infections
Menigintis symptoms and signs causes
Fever due to inflammation
Edema causeing increased ICP interfering with brain functions
causing Confuson dorwiness nause pain
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Spinal meningits casuign motor and sensory defecits
Stiffness of Neck
Fatal meningitsi killing within six hours of intial symtptoms with little time for treatment ?
as meningococcal meningitis
small drak purplish hemohhrages of blood vessels of skin apeear in menigitis this called ?
Petichae
Describe lumbar puncture cc in case of acute bacterial meinigits /
Milky turbid
leaving rapidly due to increased ICP
After centrifugation of the CSF what resultis ?
Sediment for culture
Supernatant has WBCs
and glucose and protein
Detecton of Capuslar polysaccradie antigens
Compare between bavteral viral fungal menigits supranatant
Bacterial and fungal increased protein and pressure with decreased glucose bacterial with PMNL , but fungal with Lymphocytes
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Viral normal or increased protein and pressure with normal glucose and Lymphocyte infilatraion
When you cannot perform Lumbar puncture in MENIGITIS ?
In case of patient with papilledema or Focal Neurological defecits
due to increased pressure may casue brain herniation
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in case of MASS lesion in CT scan whether abscess or tumor
Endotoxin of N,menigitdis is ?
LipooligoSaccharides
describe nessirea
Polysaccardide Capusleted Oxidase + gram - diplococci with lipooligosaccardi endotoxin on the outer membrane.
menigniococcus
Non motile non spore forming
and appear in pairs
The most common cause of purulent meningits is ?
Nessieria Menigitids called
Epidemic cerebrospinal Meningitis
how to classify N,menigitids
According to capsular polysachharide antigen to 13 serological types
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The most common are
ABCY W135
A C MOST epidmeic menigitis world wide
B sporadic
Carriage rate increased in close quarters as military camps
Mention virulence factors of the Nessieria meningitids
P2LIF
Polysaccardia capusle : antiphagocytic + antigenic for capsule
Pili for attachment to mucosa
Lipooligosaccardia capsule endotoxin for fulminant meningococcemia + septic shock
IgA proteases helping to attach to upper respiratory tract mucous degrading IgA
Factor H binding protein :
inhibiting c3b precenting Membrane attack complex and lysis = Immune evasion + used in developend of vaccine against group b meniniogcoci
used in developend of vaccine against group b meniniogcoci
Factor H binding Protein