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A-CNS MICRO > Viral encephalitis > Flashcards

Viral encephalitis Flashcards

1
Q

بسم الله الرحمن الرحيم
_______________
Symptoms and signs of Viral encephalitis

A

FEVER , HEADACHE,
Confusion Hallucination
Motor weakness ,
Personality changes

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2
Q

viral enceplatits by?

A

HAVR MECI
Herpes simplex
Arbovirus
VZV
Rabies
measels
mumps
enteroviruses
Cytmomegalovirus
INFLUENZAE

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3
Q

hsv1 REACHING ,,,,,, LOBE
by travel thorigh sensory neurons followin activation of latent infection in the ,,,,,,,,,,,,,,,,,,,

A

Temporal
_______________
Trigeminal ganglion

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4
Q

Rabies alos reaches brain by ?

A

Axonal travel from the site of bite

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5
Q

Arboviruses as WNV are acuired by mosquito bite ( culex -aedes )
and travel brain throigh

A

heamtogenous spread

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6
Q

VZV cause encephalitis in which phase?

A

Primary infection (chicken pox)
or duirng reactivation infection shingles

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7
Q

most common causes of sproadic causes of meningioencephalitis

A

HSVs

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8
Q

HSV 1-2 Casue encephalitis in ?

A

piramry infection or
reactivation in terigminal ganglion to tempral lobe

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9
Q

CMV casued encepalitis in
Epstein barr in

A

immunocmoprised
____________________-
complication of infectious mononucleosis

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10
Q

Human immunodefeicieny virus encephalitis
casue

A

Cognitive impairemtns
the HIV reaches blood brain barrier witin moncytes that can cross it fusing with microglia releasing cytokines causing inflammattion and brain injury
___________________________
HIV associated glycoproteins may interfer with synapses

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11
Q

2nd most common casue viral enceplaitis

A

West nile virus

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12
Q

MMR casue encepalits

A

Meased mumps rubella chivken
one in every 100 with measels will develop measels encephalitis deveolps 4-7 days after measels rash

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13
Q

What is the post infectious encephalitis ?

A

Mild encepahlitis after
infection or Imunization
due to autoimmune activity toward CNS antigens .
Subacute sclerosing Panencephalitis
_________________________

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14
Q

Reye’s symdome =

A

Post infectious encepalhiits VIA infection of VIA
Influenza B
VZV
Adenovirus in conjuction with
Salicylates

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15
Q

The most common cause of viral encepalitis at any time of year = 95% of cases?

A

Herpses simplex
HSV1

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16
Q

Perosnality changes aphasisa and halluscination in Herps due to ?

A

Viral transfer throug sensory nerves after being activated in terigiminal ganglion to reach Tempral and frontal lobe ofbrain
________________-
Tip : Viral transfer from the blood to CNS throuhg Olfactory Tract is suggested

17
Q

Lab investigation for viral encepalitis

A

1-CSF high lymphocytes noram glucose and protein
2-PCR for HSV and VZV for rapid treatment by IV acyclovir
3-Antibodies in fluids CSF + BLOOD
4-CT for tempral Lobea `

17
Q

Lab investigation for viral encepalitis

A

1-CSF high lymphocytes noram glucose and protein
2-PCR for HSV and VZV for rapid treatment by IV acyclovir
3-Antibodies in fluids CSF + BLOOD
4-CT for tempral Lobea `

18
Q

The most usfetl diagnostic test in Viral enceplatits is ?

A

HSV PCR ! ! ! !
MORTALITY RATE !
70%

19
Q

HSV1 praimary infection causigng ?

A

Depressed level of consciosness
CSF:
Blood tinged + high WBCs + normal protein and gluconse
PCR +
Tempral lobe focus on CT scan
Treat: IV acyclovir !!

20
Q

Arboviruses are ?

A

Viruses transmitted by blood feeding arthropds
_________________________________
enveloped RNA virus

21
Q

West Nile virus
Resvoir?
Host?
Transmission ?
Vector?
percentage?

A

Res:wild bird
Host: human dead end host
Transmission :
Bite if infected culex
Organ transplatation
Blood Transfusion
______________-
vector : culex
___________________
80 % asymptomatic
20% Occurs

22
Q

LAB investigations for west Nile virus?

A

1-Searching for specific Viral IgM in spinal fluid
2-PCR in spinal fluid
3-Isolation of virus from brain tissue or blood or spinal fluid time lost + tained perfomers?!

23
Q

Tratmetns and prefncfetion of WNV?

A

SYMPTOMATIC TRATMENT
IV FLUID + Respoatory support
___________________________
prevention : -
SURVILLANCE
VECTOR CONTROL
PEROSONAL PROTECTION
VACCINATION

23
Q

Tratmetns and prefncfetion of WNV?

A

SYMPTOMATIC TRATMENT
IV FLUID + Respoatory support
___________________________
prevention : -
SURVILLANCE
VECTOR CONTROL
PEROSONAL PROTECTION
VACCINATION

24
Q

TICK BORNE ENCEPHALISTS
____________:-
Caused by 2 closely realtded ,,,,,,,,,?
mortaility up to ……..
Fever is ……..
Transient paralysis of libs and shoulders less commonly resp musculature
Few patients are left with residual paralysis
Prevention = TBE vaccine

A

Flaviviruses
25%
Biphasic
______________

25
Q

الحمدلله رب العالـــــــــــــــــــمين

A

A-CNS MICRO (7 decks)

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