Viral encephalitis Flashcards
بسم الله الرحمن الرحيم
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Symptoms and signs of Viral encephalitis
FEVER , HEADACHE,
Confusion Hallucination
Motor weakness ,
Personality changes
viral enceplatits by?
HAVR MECI
Herpes simplex
Arbovirus
VZV
Rabies
measels
mumps
enteroviruses
Cytmomegalovirus
INFLUENZAE
hsv1 REACHING ,,,,,, LOBE
by travel thorigh sensory neurons followin activation of latent infection in the ,,,,,,,,,,,,,,,,,,,
Temporal
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Trigeminal ganglion
Rabies alos reaches brain by ?
Axonal travel from the site of bite
Arboviruses as WNV are acuired by mosquito bite ( culex -aedes )
and travel brain throigh
heamtogenous spread
VZV cause encephalitis in which phase?
Primary infection (chicken pox)
or duirng reactivation infection shingles
most common causes of sproadic causes of meningioencephalitis
HSVs
HSV 1-2 Casue encephalitis in ?
piramry infection or
reactivation in terigminal ganglion to tempral lobe
CMV casued encepalitis in
Epstein barr in
immunocmoprised
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complication of infectious mononucleosis
Human immunodefeicieny virus encephalitis
casue
Cognitive impairemtns
the HIV reaches blood brain barrier witin moncytes that can cross it fusing with microglia releasing cytokines causing inflammattion and brain injury
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HIV associated glycoproteins may interfer with synapses
2nd most common casue viral enceplaitis
West nile virus
MMR casue encepalits
Meased mumps rubella chivken
one in every 100 with measels will develop measels encephalitis deveolps 4-7 days after measels rash
What is the post infectious encephalitis ?
Mild encepahlitis after
infection or Imunization
due to autoimmune activity toward CNS antigens .
Subacute sclerosing Panencephalitis
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Reye’s symdome =
Post infectious encepalhiits VIA infection of VIA
Influenza B
VZV
Adenovirus in conjuction with
Salicylates
The most common cause of viral encepalitis at any time of year = 95% of cases?
Herpses simplex
HSV1
Perosnality changes aphasisa and halluscination in Herps due to ?
Viral transfer throug sensory nerves after being activated in terigiminal ganglion to reach Tempral and frontal lobe ofbrain
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Tip : Viral transfer from the blood to CNS throuhg Olfactory Tract is suggested
Lab investigation for viral encepalitis
1-CSF high lymphocytes noram glucose and protein
2-PCR for HSV and VZV for rapid treatment by IV acyclovir
3-Antibodies in fluids CSF + BLOOD
4-CT for tempral Lobea `
Lab investigation for viral encepalitis
1-CSF high lymphocytes noram glucose and protein
2-PCR for HSV and VZV for rapid treatment by IV acyclovir
3-Antibodies in fluids CSF + BLOOD
4-CT for tempral Lobea `
The most usfetl diagnostic test in Viral enceplatits is ?
HSV PCR ! ! ! !
MORTALITY RATE !
70%
HSV1 praimary infection causigng ?
Depressed level of consciosness
CSF:
Blood tinged + high WBCs + normal protein and gluconse
PCR +
Tempral lobe focus on CT scan
Treat: IV acyclovir !!
Arboviruses are ?
Viruses transmitted by blood feeding arthropds
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enveloped RNA virus
West Nile virus
Resvoir?
Host?
Transmission ?
Vector?
percentage?
Res:wild bird
Host: human dead end host
Transmission :
Bite if infected culex
Organ transplatation
Blood Transfusion
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vector : culex
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80 % asymptomatic
20% Occurs
LAB investigations for west Nile virus?
1-Searching for specific Viral IgM in spinal fluid
2-PCR in spinal fluid
3-Isolation of virus from brain tissue or blood or spinal fluid time lost + tained perfomers?!
Tratmetns and prefncfetion of WNV?
SYMPTOMATIC TRATMENT
IV FLUID + Respoatory support
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prevention : -
SURVILLANCE
VECTOR CONTROL
PEROSONAL PROTECTION
VACCINATION
Tratmetns and prefncfetion of WNV?
SYMPTOMATIC TRATMENT
IV FLUID + Respoatory support
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prevention : -
SURVILLANCE
VECTOR CONTROL
PEROSONAL PROTECTION
VACCINATION
TICK BORNE ENCEPHALISTS
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Caused by 2 closely realtded ,,,,,,,,,?
mortaility up to ……..
Fever is ……..
Transient paralysis of libs and shoulders less commonly resp musculature
Few patients are left with residual paralysis
Prevention = TBE vaccine
Flaviviruses
25%
Biphasic
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الحمدلله رب العالـــــــــــــــــــمين
