viral infxns

Question 1

infxn with HSV 1 or 2 is more common

Answer 1

HSV 1

Question 2

in general, HSV 1 is in the ____, HSV2 is in ____

Answer 2

oral mucosa; anogenital mucosa

Question 3

most primary HSV1 infxns present with or without sx?

Answer 3

without sx in immunocompetent ppl

Question 4

initial HSV1 lesions lasts_____days, vs reactivation lass _____days

Answer 4

10-14 days; 3 days

Question 5

herpetic whitlow is common with HSV 1 or 2

Answer 5

can be either

Question 6

most common identified cause of acute, sporadic encephalitis

Answer 6

herpes simple encephalitis

Question 7

what is mollaret syndrome?

Answer 7

occasionally recurrent meningitis assc’d with reactivation of HSV

Question 8

temporal lobe enhancement is specific for?

Answer 8

HSV encephalitis

Question 9

best test for dx of herpes

Answer 9

PCR

Question 10

resistance to acylclovir results from??

Answer 10

lack of thymidine kinase

Question 11

what are the topical antivirals used for eye infxns (3)

Answer 11

1. idoxoridine
2. trifluridine
3. vidarabine

Question 12

primary infxn with VZV?

Answer 12

varicella (chickenpox)

Question 13

reactivation with VZV?

Answer 13

zoster (shingles)

Question 14

transmission of VZV

Answer 14

aerosolized droplets from nasopharynx or direct contact with vesicle fluid

Question 15

most common visceral complication of varicella?

Answer 15

pneumonia

Question 16

risk factors for varicella pneumonia

Answer 16

smoking, pregnancy, immunosuppression

Question 17

best tx option of varicella

Answer 17

high dose acyclovir

Question 18

where does reactivation of latent herpes zoster occur?

Answer 18

sensory DRG in T3-L3

Question 19

herpes zoster, facial paralysis, hearing loss

Answer 19

ramsey-hunt syndrome

Question 20

reason to start tx for herpes zoster ASAp?

Answer 20

decr incidence of post-herpetic neuralgia

Question 21

tx of herpes zoster

Answer 21

acyclovir, famcyclovir

Question 22

what herpes virus are most adults sero-positive for?

Answer 22

EBV

Question 23

where does EBV have its latency?

Answer 23

in B and T cells, epithelial cells, myocytes

Question 24

tx for EBV if sx under 3 weeks

Answer 24

watchful waiting

Question 25

dx of EBV?

Answer 25

EBV specific Ab–>VCA (IgG, IgM)

Question 26

large cells, intranuclear owls eyes inclusion, occ cytoplasmic inclusions

Answer 26

CMV

Question 27

what differentiation EBV and CMV mononucleousus?

Answer 27

EBV mono has exudative pharyngitis & cervical adenopathy

Question 28

what is the most important viral pathogen complication transplantation?

Answer 28

CMV

Question 29

tx of CMV

Answer 29

ganciclovir/valganciclovir

Question 30

major toxicity assc’d with ganciclovir/valganciclovir

Answer 30

neutropenia

Question 31

toxiciity assc’d with foscarnet

Answer 31

renal, electrolytes, seizures