viral infxns Flashcards
infxn with HSV 1 or 2 is more common
HSV 1
in general, HSV 1 is in the ____, HSV2 is in ____
oral mucosa; anogenital mucosa
most primary HSV1 infxns present with or without sx?
without sx in immunocompetent ppl
initial HSV1 lesions lasts_____days, vs reactivation lass _____days
10-14 days; 3 days
herpetic whitlow is common with HSV 1 or 2
can be either
most common identified cause of acute, sporadic encephalitis
herpes simple encephalitis
what is mollaret syndrome?
occasionally recurrent meningitis assc’d with reactivation of HSV
temporal lobe enhancement is specific for?
HSV encephalitis
best test for dx of herpes
PCR
resistance to acylclovir results from??
lack of thymidine kinase
what are the topical antivirals used for eye infxns (3)
- idoxoridine
- trifluridine
- vidarabine
primary infxn with VZV?
varicella (chickenpox)
reactivation with VZV?
zoster (shingles)
transmission of VZV
aerosolized droplets from nasopharynx or direct contact with vesicle fluid
most common visceral complication of varicella?
pneumonia
risk factors for varicella pneumonia
smoking, pregnancy, immunosuppression
best tx option of varicella
high dose acyclovir
where does reactivation of latent herpes zoster occur?
sensory DRG in T3-L3
herpes zoster, facial paralysis, hearing loss
ramsey-hunt syndrome
reason to start tx for herpes zoster ASAp?
decr incidence of post-herpetic neuralgia
tx of herpes zoster
acyclovir, famcyclovir
what herpes virus are most adults sero-positive for?
EBV
where does EBV have its latency?
in B and T cells, epithelial cells, myocytes
tx for EBV if sx under 3 weeks
watchful waiting
