CNS infections Flashcards
yellowish supernatant of CSF that is a result of RBC lysis
xanthochromia
xanthochromia indicates the presence of?
oxyhemoglobin, methehemoglobin, bilirubin
seizures can do what to CSF?
transient CSF pleocytosis with counts under 80, and all other normal values
white counts are usually the highest with _______
bacterial meningitis
bacterial meningitis presents with _____whites counts, ____glu, differential with _____, _____protein
high white counts, low glu, differential with neutrophils, high protein
cryptococcal meningitis presents with ____WBC, ____glu, differential wit____
moderately elevted WBC, low glu, differential with mononuclear cells
viral meningitis presents with WBC under _____, ___glu, protein____
WBC under 500, elevated glu, protein under 200
normal CSF: serum glu ratio
0.6
CSF hypoglycorrhachia
low CSF glu
csf protein concentrations over _____is abnormal
50
entry of agents into CSF is enhanced by ___MW, ___degree of ionization, ____lipid solubility, ____degree of protein binding
low MW, low degree of ionization, high lipid solubility, low degree of protein binding
_____and ______ are responsible for 80% of acute bacterial meningitis cases in adults
Strept pneumo and neisseria are responsible for 80% of acute bacterial meningitis cases in adults
bacteria that can cause acute, subacute, or chronic meningitis (3)
- M TB
- treponema pallidum
- borrelia burgdorferi
how to empircally tx acute bacterial meningitis
IV vancomycin + 3rd gen cephalosporin
what to use to tx listeria as causative agent of acute bacterial meningtiis?
ampicillin
what is the triad for meningitis
HA, fever, meningismus
in someone who has had neurosurgery & now acute bacterial meningitis, what bug to suspect
coagulase negative staphy species
how to tx acute bacterial meningitis in someone with neurosurg
vancomycin + ceftazidime or cefepime or meropenem
what commonly used drug can you NOT use to tx acute bacterial meningtis?
extended PCN
The only pathogen that has been studied and had positive results with steroid admin is ______
strept pneumo
listeria acute meningitis should be tx’d for a minimum of _____
3 weeks
Neisseria & H influenzase acute meningitis should be tx’d for how long
7 days
tx S pneumoniae acute meningitis for how long
10-14 days
tx GBS acute meningitis for how long
14-21 days
