Viral Infections Flashcards
diseases caused by herpes simplex virus 1 and 2
primary herpetic gingivostomatitis
recurrent herpes (intraoral, labialis)
ocular herpes
genital herpes
diseases caused by varicella zoster virus
chicken pox
herpes zoster
diseases caused by epstein barr virus
infectious mononucleosis
hairy leukoplakia
nasopharyngeal carcinoma
certain types of lymphomas
diseases caused by cytomegalovirus
diseases of salivary glands and lymph nodes
diseases caused by herpesvirus 6 and 7
exanthema subitum
exanthem infantum
roseola infantum
diseases caused by herpesvirus 8
kaposi’s sarcoma
neurotropic (definition)
will be transported via nerves to sensory ganglia
which two viruses are neurotropic?
HSV 1 and 2
Varicella zoster
how herpes simplex virus spreads to cause infection
spreads through saliva, usually during early childhood
Clinical spectrum of HSV infection
95% primary infections are subclinical
5% primary herpetic gingivostomatitis (have aphthous ulcers)
diagnosing HSV infection
-clinical presentation characteristic
-exfoliative cytology
-viral culture
-sequential serum antibody titers
-immunohistochemistry on sampled tissue
epithelial cell morphology for HSV infection
each cell has multiple large nuclei with glassy chromatin
ballooning degeneration
management of HSV within first few days
acyclovir
later management of HSV
symptomatic care
topical anesthetics
avoid dehydration
prognosis for HSV
generally good
episodes last 10-14 days (without treatment)
preventative measures for HSV
care should be taken not to spread virus to other body sites or other people during active infection
triggers for HSV infection
triggered by UV light exposure or trauma
prodromal symptoms of HSV infection
prodromal itchign or tingling
features of established HSV lesion
erythema, followed by cluster of vesicles
Measures that can be taken to reduce recurrence of HSV infection
-avoid excess sun exposure
-sunblock
-topical antiviral agent
herpetic whitlow is a hazard associated with not wearing…
gloves
should you work on patients if you have herpetic whitlow?
no!
incubation period of varicella zoster virus / chicken pox
10-20 days
lesion characteristics of chicken pox
intensely pruritic exanthum
dew drop on a rose petal
evolution of lesions over course of chicken pox
erythema –> vesicle –> pustule –> crust
complications associated with chicken pox
-more severe in adults
-reye’s syndrome
-secondary skin infections
epithelial cell morphology with HSV infections
acantholysis and free floating Tzanck cells
multinucleated epithelial cells
diagnosis of chicken pox
history of exposure
characteristic exanthum
rapid diagnosis from VZV antibodies
treatment of chicken pox
antipyretics
avoid aspirin