Viral hepatitis Flashcards
What route is hep a transmitter
Oro faecal
Where is Hep A more common
In countries where access to clean water is poor
Among MSM
What is incubation period for Hep A
2-6 wks
What are symptoms for hep a
jaundice
malaise
RUQ discomfort
What is the type of disease that Hep A causes
ACUTE (either resolves or people die)
WHAT does a HEP A + person show on investigation
HIGH IgM
high ALT
What does a Hep A vaccinated person show on ix
High IgM, IgG
Normal ALT
What is the illness course of Hep B
acute > chronic / resolves
What is the surface antigen of Hep B
HBsAg
What is the core antigen of hep B
HBcAg
What antigens do you have ONLY if you HAVE Hep B (rather than vaccine)
HBcAg
HBeAg
What is the marker of Hep B immunity
HBsAb
What are you positive for if you’ve had Hep B vaccine
HBsAb // anti-Hbs
When does anti-HBs form
last antibodies to form after resolution of infection
OR
formed by vaccine
What are you positive for if you have acute HBV infection
+ HBsAg, Anti-HBc IgG, Anti-HBc IgM
What are you positive for if you have chronic HBV infection
+ HBsAg, Anti-HBc IgG
What are you positive for if you have resolved HBV infectioon
+ antiHBc IgG, anti-HBs
What is the worse consequence of HBV
Hepatocellular carcinoma
How do you treat chronic HBV ?
Pegylated interferon alpha
Nucleotide analogues e.g. TENOFOVIR, ENTECAVIR
What is the course of HCV?
Acute infection > high likelyhood to become chronic
What is the incubation period for HCV
6-8 weeks
How do you detect HCV in blood
HCV RNA
What do you detect if someone has HDV
IgM anti-HDV
When does HDV infection occur
ONLY with confection with hep B
