GI infection Flashcards
Clostridium Botulinum - Associations
Canned/vacuum packed foods
Honey (kids), beans (sudents)
Clostridium Botulinum MoA
blocks Ach release from peripheral nerves
What is the presentation of Clostridium Botulinum
descending paralysis
Clostridium perfringens ASSOCIATONS
reheated meats
acts on small bowel
What are symptoms of clostridium perfringens
watery diarrhoea and cramps
What are associations for bacillius cereus
reheated rice
sudden vomting
what are symptoms with bacillus cereuss
watery diarhoea
Explain S aureus GI infection
Produces enterotoxin, which acts as superantigen> releases IL1, IL2 > vomiting, watery diarrhoea
Which E coli species is responsible for HUS
EHEC - produces verotoxin (shiga-like)
Which E cosi speecies is responsible for infantile diarrhoea
EPEC
Which E coli is responsible for invasive dysentery (bloody diarrhoea)
EIEC
What does salmonella typhi and paratyphi present as in the colon
Peyer’s patches
What are classical symptoms of typhi/paratyphi
ROSE SPOTS (pink spots on abdo)
Slow onset fever
Constipation
Relative bradycardia
Explain action of shigella
Affects distal ileum + colon
Mucosal inflamm, fever, pain, bloody diarrhoea
Explain Yersinia enterocolitis
Enterocolitis
Mesenteric adenitis with necrotising granuloma
Erythema nodosum
How does vibrio cholera present
Rice water shool
How does vibrio cholera occur
Open chloride channel > efflux of Cl- to lumen > efflux of electrolytes and water
What is the shape of campylobacter jejuni
Curved, comma, S shaped
What are associations of campylobacter
Drinking unpasteurised milk / ucooked poultry
Which pathogen causes a flask shaped ulcer on histology
Entamoeba histolica
How do you diagnoose Giard
ELISA string test
