GI infection Flashcards

1
Q

Clostridium Botulinum - Associations

A

Canned/vacuum packed foods

Honey (kids), beans (sudents)

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2
Q

Clostridium Botulinum MoA

A

blocks Ach release from peripheral nerves

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3
Q

What is the presentation of Clostridium Botulinum

A

descending paralysis

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4
Q

Clostridium perfringens ASSOCIATONS

A

reheated meats

acts on small bowel

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5
Q

What are symptoms of clostridium perfringens

A

watery diarrhoea and cramps

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6
Q

What are associations for bacillius cereus

A

reheated rice

sudden vomting

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7
Q

what are symptoms with bacillus cereuss

A

watery diarhoea

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8
Q

Explain S aureus GI infection

A

Produces enterotoxin, which acts as superantigen> releases IL1, IL2 > vomiting, watery diarrhoea

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9
Q

Which E coli species is responsible for HUS

A

EHEC - produces verotoxin (shiga-like)

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10
Q

Which E cosi speecies is responsible for infantile diarrhoea

A

EPEC

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11
Q

Which E coli is responsible for invasive dysentery (bloody diarrhoea)

A

EIEC

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12
Q

What does salmonella typhi and paratyphi present as in the colon

A

Peyer’s patches

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13
Q

What are classical symptoms of typhi/paratyphi

A

ROSE SPOTS (pink spots on abdo)
Slow onset fever
Constipation
Relative bradycardia

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14
Q

Explain action of shigella

A

Affects distal ileum + colon

Mucosal inflamm, fever, pain, bloody diarrhoea

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15
Q

Explain Yersinia enterocolitis

A

Enterocolitis
Mesenteric adenitis with necrotising granuloma
Erythema nodosum

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16
Q

How does vibrio cholera present

A

Rice water shool

17
Q

How does vibrio cholera occur

A

Open chloride channel > efflux of Cl- to lumen > efflux of electrolytes and water

18
Q

What is the shape of campylobacter jejuni

A

Curved, comma, S shaped

19
Q

What are associations of campylobacter

A

Drinking unpasteurised milk / ucooked poultry

20
Q

Which pathogen causes a flask shaped ulcer on histology

A

Entamoeba histolica

21
Q

How do you diagnoose Giard

A

ELISA string test