Infection CPC Flashcards
What is first line treatment for Pneumocisti jirovecii pneumonia
Co-trimoxazole
What is second line treatment for Pneumocisti jirovecii pneumonia
Clindamycin + Primiquine
What kind of examination and staining confirms Pneumocisti jirovecii pneumonia
Broncheoalveolar lavage cytology
Using SILVER STAIN (Grocott-Gomori stain)=
What fungus causes fungal meningoencephalitis in immunocompromised patients
Cryptococcus
What causes lung abscess in alcoholic & immunocompromised patients?
ACTINOMYCES lung abscess
What is the pattern of growth for ACTINOMYCES lung abscess
VERY SLOW
difficult to treat
What staining can you use for acinomyces
Gram stain
Grocott stain
What does staining for acinomyces show
Basophilic sulphur granules
Gram + rods that branch out as they grow
How do you treat osteomyelitis?
antibacterial therapy
debridement and removal of prosthesis
How do you manage someone with + C diff?
- isolate in single room
- assess severity
- stop offending antibiotic
- treat per guidelines
What is the C diff severity score
Severe = 1 or more of the following:
- Temp >38.5
- HR >90
- WCC >15
- Rising creatinine
- Severe colitis
- failure to respond to therapy in 72h
How do you treat non-severe C diff
ORAL Metronidazole
How do you treat severe C diff
metronidazole + vancomycin
What are RF for C diff diahrroe
- antibiotics
- > 65 years old
- long hospital stay
- severe underlying disease
- use of PPIs (raise pH of stomach)
What is the action of C diff on the bowel?
Produces toxin A and toxin B
- toxin A damages epithelial cells (cytotoxin)
- toxin B distrupts tight junctions, causing fluid loss into bowels
