Viral Diarrhea Flashcards
structure/genome of astrovirus
targets of sporadic and outbreaks of infection?
naked, icosahedral, ssRNA(+)
sporadic infection in children
outbreaks in any age; >70% of adults have antibody
all relavent viruses causing diarrhea
rotavirus
enteric adenovirus
astrovirus
caliciviruses(norovirus, sapovirus)
serotypes of adenovirus causing gastroenteritis
serotypes 40 and 41
most likely cause of acute outbreak of nonbacterial gastroenteritis
caliciviruses
pathogenesis of rotavirus
blunts microvillie
decreases absorption
inhibits disaccharide absorption
inflammation
enteric adenovirus primarily affects who?
children
4-10% of sporadic diarrhea in children is caused by enteric adenovirus
structure/genome of rotavirus
naked, icosahedral dsRNA(11 segments; can rearrange)
dsRNA is unique to rotavirus
increased risk of diarrheal infection for O blood type
which virus?
norovirus(a calicivirus)
rotavirus symptoms, duration
HANVD w/low grade fever
lasts 4-8 days; about a week
vaccines for diarrheal virus
rota Teq
Rotarix
ROTAVAC
can be 90% effective against severe; 70-80% for regular
ROTAVIRUS
function of VP7, VP4, VP6, NSP4 in rotavirus
VP7 - cleaved in stomach to activate virus; surface protein
VP4 - allows attachmentto epithelial cells in smal lintestine after activation
VP6 - inner capsid protein; diagnostic antigen
NSP4 - enterotoxin, causes chloride secretion/diarrhea
seasonality for rotavirus, noravirus
winter peak
difference between enteric adenovirus and rotavirus infections?
enteric adenoviruses can last 5-12 days; a little longer than rotavirus(4-8)
duration/incubation for calicivirus
1-2 days for incubation
1-2 days for duration
most common cause of severe diarrhea in children
rotavirus
