Measles, Mumps, Rubella, Parvovirus

Question 1

increased severity for this viral infection w/Vitamin A deficiency

Answer 1

Measles

Question 1

clinical manifestation of parvovirus B19

Answer 1

1. erythema infectiosum - fever/malaise followed by characteristic cheek rash
2. arthralgia - most common in women
3. anemia
   
   • can become aplastic in individuals w/hemoglobinophathies(sickle cell)
   • worse for immunocompromised
4. risk of fetal hydrops if mama is infected
   
   • bad for pregos to get parvo
5. myocarditis

Question 2

paramyxovirus causing transient, profound immunosuppression

allows for secondary infections:BAD diarrhea, pneumonia

Answer 2

measles

Question 3

genomes of measles, mumps, rubella, parvovirus B19

Answer 3

• measles, mumps - ssRNA(-)
• rubella - ssRNA(+)
• parvovirus B19 - ss/linear DNA

Question 3

congenital rubella syndrome trifecta

Answer 3

cataracts

heart disease

deafness

“blueberry muffin” rash from BM cells;

Question 4

clinical manifestation of rubella

Answer 4

Rash(occurs w/fever) - more patchy than the confluent measles rash; moves head–>toe, disappearing in same order, a few days later

cervical lymphadenopathy

arthritis

Question 5

complications of measles

Answer 5

transient immunosuppression: allows coinfections

encephalitis: acute, acute disseminated, sub acute sclerosing panencephalitis(years later)

worse if immunosuppressed, malnutritious(vit A)

Question 6

why rubella vaccine?

Answer 6

can spread from mother>>child if mama is infected in first trimester and cause congenital rubella syndrome. DO IT FO DA BABIES

Question 8

extremely small, naked, icosahedral, ssDNA virus that infects/kills bone-marrow precursor cells

Answer 8

parvovirus B19

Question 9

erythema infectiosum or 5th disease

symptoms?

virus?

Answer 9

Parvovirus B19

**initially **causes mild fever, malaise, myalgia, HA

followed by“slapped-cheek rash” on face and lace-like rash on body

Question 11

transmission for measles, mumps, rubella, parvovirus B19?

Answer 11

respiratory droplets is a common transmission for all

Question 12

clinical features mumps

Answer 12

systemic disease

POM- parotiditis, orchitis(testes swelling), meningitis(Aseptic)

Question 13

Slapped cheek rash

viral cause?

Answer 13

parvovirus B19

Question 14

clinical features of measles

Answer 14

the 3 C’s(and a k)

• conjunctivitis
• cough
• coryza(runny nose)
• Koplik’s spots - enanthem; white spots in mouth;

Rash follows the koplik’s spots; starts as dots that later become confluent

Question 15

complications of mumps

Answer 15

encephalitis

deafness(leading cause before vaccine)

infertility(RARE)