Encephalitis Viruses Flashcards
most aggressive/deadly of mosquito-borne encephalitis virus
EEEV
5% of people get encephalitis; causes mortalilty and permanent disabilities
replication of rabies virus
glycoprotein attaches to receptors on target cell
enters/starts transcribing
when nucleoprotein accumulates, virus switches to replication
coats itself and bounces
pathogenesis of rabies
Enters muscle cells; replicates slowly here
Eventually works its way up motor neuron via retrograde axonal transport
Replicates/spreads through CNS - NEGRI BODIES
Disseminates via peripheral nerves ALL OVA DA BODY(saliva, skin, etc)
prognosis for la crosse virus
mortalitly is rare
most people recover w/few sequelae
pathogenesis of west nile virus
- mosquito bite
- DC take up virus
- viremia(symptoms)
- CNS penetration, neuro invasion
- higher rates in immunocompromised AND CCR5delta32 mutants
in general, what are the number of cases seen each year for each mosquito-borne encephalitis in the US?
west nile >1000
st. louis ~100
EEV/WEEV ~5 each
La Crosse ~100
clinical manifestation of rabies
- prodrom/early: flu; parasthesia
- acute neuro disease: encephalopathic(bizarre behavior) OR paralytic(ascending paralysis)
- DEATH
mosquito-borne encephalitis viruses
west nile, st. louis (flavi)
EEV, WEEV (toga)
la crosse (buny)
treatment for rabies in the “window of opportunity”/before CNS
- clean wound well
- rabies immune globulin
- Vaccine(multiple Im doses in deltoid); LIVE ATTENUATED
la crosse virus is most commonly seen in what area of US
upper mid-west, but spreading to central atlantic
la crosse virus structure
enveloped, helical, ssRNA(-)
EEEV cases in US are from what areas?
WEEV cases in US are from what areas?
EEEV - swamps/summer time
WEEV - western/central states
unique aspect of structural protein transcription in EEEV, WEEV
even though thes are ssRNA(+), structural proteins are made through a RNA(-) intermediate
