VirAdAnt

Question 1

What two factors does adherence require?

Answer 1

host receptor

bacterial adhesin

Question 2

What are the two processes of adhesion?

Answer 2

1. pilus (fimbria)-for attachment at a distance

2. non-fimbrial adhesion (outer membrane protein)-for intimate attachment

Question 3

Are there different pili for different environments?

Answer 3

-yes
gonorrhea (vag vs rectum)
e coli ( bladder vs kidney)

Question 4

What is antigenic diversity of pilis?

Answer 4

• varying adhesion composition to avoid immune system

- different antigens

Question 5

What is pilE, pilS?

Answer 5

pilE-expressed due to promoter
-antigenicity depends upon the sequence of pilE
pilS-silent genes due to lack of promoter and imcomplete

Question 6

How do the genes in pilE change?

Answer 6

1. gene conversion
   - from pilS=endogenote
2. transformation
   - from pilS=exogenote

-infinite possibilities because there isnt 100% swap