Vestibular System Flashcards

1
Q

What is the function of the vestibular system?

A

Essential in producing motor responses; necessary for daily funciton

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2
Q

What are the 5 components of the vestibular system?

A
Peripheral receptor apparatus
Central vestibular nuclei
Vestibulo-ocular network
Vestibulo-spinal network
Vestibulo-thalamic cortical network
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3
Q

Where is the peripheral receptor apparatus?

What is the function of it?

A

Inner ear

Transduces head motion/position

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4
Q

Where is the central vestibular nuclei?

What is their function?

A

Brainstem

Integrates and distributes info that controls motor activities and spatial orientation

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5
Q

Where is the vestibule-ocular network?

What is its function?

A

Vestibular nuclei

Controls eye movements

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6
Q

What is the function of the vestibulo-spinal network?

A

Coordinated head movements, axial musculature, and postural reflexes

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7
Q

What it’s he function of the vestibule-thalamic cortical network?

A

Conscious perception of movement/spatial orientation

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8
Q

What the the vestibular receptor organs?

A

Semicircular canals

Otoliths organs (utricle and saccule)

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9
Q

What kind of movement does semicircular canal detect?

A

Rotational head movements

Angular accelerations

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10
Q

What kind of movement do otoliths organs detect?

A

Linear accelerations

Translation head movements

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11
Q

What are the receptors of vestibular organs innervated by?

A

Primary afferent fibers of vestibular ganglion (Scarpa ganglion)

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12
Q

Where do central porcesses vestibular ganglion enter and terminate?

A

Enter brainstem

Terminate in ipsilateral vestibular nuclei and cerebellum

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13
Q

Where is perilymph?

A

B/w membranous and bony labyrinths

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14
Q

Where is endolymph found?

A

Membranous labyrinth, bathing receptors of auditory and vestibular system

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15
Q

What maintains the ion concentrations of peri and endolymph?

A

Concentrations maintained by secretory cells in membranous labyrinth and endolymphatic sac

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16
Q

What is a vestibular disease caused by?

A

Disturbances in volume or ionic content of endolymph

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17
Q

What is the blood supply to the vestibular system?

A

Labyrinthine a. (Branch of AICA)

Stylomastoid a.

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18
Q

How does the labyrinthine a. Enter temporal bone

A

Via IAM

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19
Q

What happens if the labyrinthine a. Is compromised?

A

Compromised vestibular and cochlear funciton

Vertigo, nystagmus and/or unstable gait

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20
Q

What do type 1 and 2 hair cells contain?

A

Contain 60-100 stereocilia

1 kinocilium

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21
Q

What innervates

Type 1 hair cells?

Type 2?

A

Cn 8 via nerve calyx

Cn 8 via boutons

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22
Q

What does movement of stereocilia toward kinocilium cause?

A

Depolarization and AP

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23
Q

What does movement of stereocilia away from kinocilium cause?

A

Hyperpolarization

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24
Q

What is the ampullae?

How are the hair cells distributed in it?

A

Semicircular ducts

Hair cells in cristae across base of ampulla and extending into cupulla

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25
Q

What is the function of the ampulla?

A

Rotational and angular accelerations

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26
Q

How do angular accelerations act on the ampulla?

A

Displace endolymph

—>

Bends cupulla

—>

Displace stereocilia

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27
Q

What does the macula consist of?

A

Utricle and saccule

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28
Q

How are hair cells organized in the macula?

A

Hair cells’ stereocilia extends into gelatinous otoliths membrane covered by otoconia

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29
Q

What is the function of the macula?

A

Detect gravity/linear accelerations

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30
Q

How does gravity/linear accelerations act on the macula?

A

Displace otoconia
—>
Bend underlying hair cell stereocilia

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31
Q

Where do the priamry afferent of the vestibular system come from and enter at?

A

Primary aff. = cn 8
From ampullae or macula
Thru scarpa ganglion
Enter at pontomedullary junction

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32
Q

Where do primary afferents of the vestibular system project to?

A

Vestibular nuclei (superior, medial, later, and inferior) IPSILATERALLY

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33
Q

What do the vestibular nuclei encode?

A

Direction, speed of movement, and head position

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34
Q

What do the 2nd order nuerons coming from vestibular nuclei target?

A

CNs 3,4, 6 nuclei

And 
Vestibulocerebellum 
SC
RF
Thalamus
35
Q

Where do the vestibular nuclei project to?

A

Ventral posterior nuclear complex in thalamus

36
Q

Where do thalamic nuclei go to?

What are they conveying?

A

To cortical regions of S1, Parietoinsular vestibular cortex, posterior parietal cortex

Relay vestibular input needed for processing motion and body orientation

37
Q

What happens if the Parietoinsular vestibular cortex is lesioned?

A

Vertigo
Unsteadiness
Loss of visual vertical

38
Q

What happens if the posterior parietal cortex is lesioned?

A

Confusion in spatial awareness

39
Q

What are vestibulovestibular fibers?

A

Reciprocal connections b/w R and L vestibular nuclei

R side activ. —> L side inhibited

40
Q

Where are spinovestibular fibers from?

What do they provide?

A

From all SC levels

Provide proprioceptive input

41
Q

What are the vestibulocerebellar fibers?

Where do they project to ?

A

Fibers thru juxtarestiform body

Sends DIRECT projection to cerebellum

(Only sensory organ body that does this)

42
Q

What do primary vestibulocerebellar fibers target?

What kind of fibers are these?

A

Dentate nucleus of cerebellum

Mossy fibers

43
Q

What do the secondary vestibulocerebellar fibers target?

A

Flocculonodular lobe - fastigial and dentate nuclei

44
Q

What do the reciprocal cerebelli vestibular fibers provide?

A

Regulatory mechanisms for coordinating eye movements, head movements, and posture

45
Q

What nuclei does the lateral vestibulospinal tract come from?

A

Inferior and lateral nuclei

46
Q

Where does the lateral vestibulospinal tract project to?

What does it control?

A

Projects to ipsi SC at cervical and lumbosacral regions

Controls extensors for maintenance of posture

47
Q

Where does the medial vestibulospinal tract come form?

What is the input to it?

A

Medial vestibular nucleus

Integrated input from vestibular receptors, cerebellum and PCMLS

48
Q

What is the pathways of the medial vestibulospianl tract?

What is the function?

A

Medial vestibular nucleus —> MLF —> Cervical SC

Stabilize neck flexor and extensor musculature

49
Q

What reflex is the medial vestibulospianl tract needed for?

A

Critical in vestibulo-colic reflex

Stabilizes head via activation of neck musculature

50
Q

What is the Vestibulo-ocular reflex for?

A

Stabilizes images on retina during head movements thru vestibular input

51
Q

Describe the vestibulo-ocular reflex

A

Head rotates —> endolymph moment in semicircular canals —> vestibular input about head motion —> drives COUNTER ROTATION of EYES

52
Q

What is the slow phase of eyes characterized by?

A

Eyes move away from head motion

53
Q

What is the fast phase of eyes characterized by?

A

Eyes snap black toward head motion

54
Q

What is needed in order for the vestibulo=ocular reflex to occur?

A

Need activation of ocular muscle for slow phase via vestibular apparatus

55
Q

In the vestibulo ocular reflex,

What happens when you turn your head to the right?

A
Fluid in right semicircular ducts—> activate right afferent fibers 
—> 
Right vestibular nuclei 
—> 
CN 6 
— inter-nuclear neurons via MLF —>CN 3

—> Lateral rectus, Medial rectus

56
Q

What links left lateral rectus with the right medial rectus?

A

Internuclear nuerons

Go from CN 6 —> CN 3 using MLF

57
Q

What is the Vestibulo=ocular reflex?

A

Push pull mechanisms that unifies movements of eyes thru bilateral symmetry of VOR circuits

58
Q

What will the left vestibular apparatus do when the head is rotated right?

A

Left vestibular afferents are inhibited

Cause complementary circuit to relax

(Via vestibulovestibular fibers)

59
Q

What is physiological nystagmus?

A

Combo of slow phase punctuated by fast return phase

60
Q

How do we name physiological nystagmus ?

A

For the fast phase

The direction he head is turning

61
Q

What does unilateral damage to the vestibular system cause?

A

silences output from damaged side causing steady firing of intact side by CN 8

Causes spontaneous nystagmus, vertigo, falls, and vomiting

62
Q

What will peripheral damage to vestibular labyrinth or CN 8 cause?

A

Imbalance b/w left and right vestibular input

Nystagmus

63
Q

What happens if there is central damage to the brainstem or cerebellar strucutres ?

A

Nystagmus w/ impaired voluntary saccades and/or smooth pursuit

64
Q

How do you test for nystagmus?

A

Caloric test

65
Q

In the caloric test what will warm water cause?

A

Nsytagmus that beats toward irrigated ear

I.e. fast phase is toward ear irrigated

66
Q

In the caloric test, what will cold water cause?

A

Nystagmus that beats AWAY from irrigated ear

If r. Ear done, fast phase will be toward the left

67
Q

What is Ménière’s disease caused by?

A

Disruption of normal endolymph volume causing endolymphatic hydrops (distortion of membranous labyrinth)

68
Q

What are the Sxs of Ménière’s disease?

What are the txs for Ménière’s disease?

A
fluctuating hearing loss
Vertigo
Positional nystagmus
Nausea 
Tinnitus 

Restrict salts and diuretics to reduce hydrops, implant shunt to endolymphatic sac

69
Q

What is benign paroxysmal positional vertical characterized by?

Caused by?

A

Brief episodes of vertigo that coincide w/ changes in body position

Cupololithiasis

70
Q

What is cupololiithiasis

A

Otonconia crystals lodged in cupola of semicircular changes that will change the movemnt of endolymph and cause feeling of motion when headchanges positions

71
Q

What is vestibular schwannoma (Acoustic neuroma)

A

Benign tumor from Schwann cells in vestibular root

72
Q

Where is a vestibular schwannoma?

What will it impinge on?

A

Within cerebellopontine angle

Structures traversing IAM
CN 7,8, labyrinthine a.

73
Q

What are the symptoms of Vestbiular schwannoma?

A

Hearing loss, gait difficulties, tinnitus

74
Q

What is vestibular neuritis caused by?

A

Edema of vestibular n. Or ganglion due to recent viral infection (i.e. herpes simplex)

75
Q

What are the symptoms of vestibular neuritis?

What will patients report recent history of?

Txs?

A

Severe vertigo
Nausea
Vomiting
NO HEARING LOSS THOUGH

Recent Hx of URI, Cold, or influenza

Antiemetic, vestibular suppressants, corticosteroids, and antiviral agents

76
Q

What is dizziness?

A

Non specific term for spatial disorientation

May or may not feel movement
Could have nausea or postural instability

NOT EXCL. Vestibular in origin

77
Q

What is vertigo?

A

Illusion of body motion, often spinning

78
Q

What is subjective vertigo?

A

Patient feels spinning while things in environment are not moving

79
Q

What is objective vertigo?

A

Patient not moving but has sensation of object spinning

80
Q

What is the oculocephalic reflex?

A

A head rotated back and forth will have yes that move in opposite direction

81
Q

Do you see an oculocephalic reflex in conscious patients?

A

NO

Voluntary eye movements mask reflex

82
Q

How can the oculocephalic reflex be used in comatose patients?

A

To asses brainstem function

If brainstem is intact, doll’s eye reflex is present

83
Q

What happens if there is a lesion to MLF?

A

One eye = abducted

Other one does not move

INO

(Remember that the MLF is the tract for internuclear neurons)