Vesiculobullous and Immune Disease 1 Flashcards
how many types of hypersensitivity is there
5
what are three examples of local immunological oral disease
apththous ulcers
lichen planus
orofacial granulomatosis
what are examples of immunological oral diseases that are systemic with local effects
pemphigus
pemphigoid
lupus
systemic sclerosis
sjogren’s
why do skin diseases that affect the mouth also affect the genital region
oral and genital mucosa share many common antigens and epitopes because they share the same origin
what are epitopes
the place where an antibody will bind on the antigen
what are antigens
big immunogenic sites on a protein
what causes loss of cell-cell adhesions
auto-antibody attack on skin components
what protein is involved in immunobullous diseases
desmoglein
what is the function of the protein desmoglein
adhesion in desmosomes
keeps epithelial cells together
what is direct immunofluorescence
manufacturing another antibody that has fluorescence marker bound to it that will bind to antibody of interest in the tissue
what is the purpose of direct immunofluorescence
to show where exactly in the tissue an antibody is found
what is indirect immunofluorescence
the circulating antibody is not yet bound to tissue so a plasma sample is taken and use immunofluorescence to monitor
what is erythema multiforme
spectrum disorder caused by immunogenic skin and mucosa ulceration
what is the immunological cause of erythema multiforme (how does the blistering occur)
antigen presents that is targeted by antibody which prompts immune response - the antigens and antibodies combine in circulation causing a large complex which gets wedged in tissue and activates complement causing perivascular response = blistering of tissue
what is the aetiology of erythema multiforme
drugs
herpes simplex
mycoplasma
