Venous Uclcer in IVDU

Question 1

Q1. What type HCV is?

Answer 1

RNA Virus

Question 2

Q2. Which 3 main pathologies linked to HCV infection?

Answer 2

Chronic Hepatitis / Liver cirrhosis / Incr. risk of HCC

Question 3

Q3. What’s Necrotizing Fascitis?

Answer 3

Deep soft tissue acute and necrotizing inflammatory reaction with associated necrotic tissue. It’s usually involve polymicrobial bacteria usually 2 or more

Question 4

Q4. Explain 4 reseaons How IVDU injecting into the groin develop leg venous ulcer?

Answer 4

1. Repeated injections to the groin cause direct injury to soft tissue and vessels, resulting in scarring.
2. Repeated injury narrows venous circulation, leading to soft tissue hypoxia and skin ulceration.
3. The drug contains toxic materials, causing local venous thrombosis and inflammation.
4. Scarring from injections reduces arterial cross-section, impairing leg arterial circulation and worsening the above conditions.

Question 5

Q5. Despite treatment the leg ulcer grows to a diameter of 45mm with full thickness ulceration of the deep soft tissues, the edges appear edematous & inflamed. What types of necrosis likely to be ongoing at this site?

Answer 5

Ischemic or coagulative necrosis

Question 6

Q6. Aside from coagulative necrosis what other necrotic patterns could be recognised?

Answer 6

Liquafactive / Caseous / Gammatous for syphilis

Question 7

Q7. What do you understand by the pathology term necrosis?

Answer 7

Cell death that not require energy

Question 8

Q8. What type of cell death process requires energy?

Answer 8

Apoptosis

Question 9

Q9. The groin LNs are enlarged & tender, which part of the LN is usually responsible of the enlargement in an inflammatory or infective situation?

Answer 9

Cortical

Question 10

Q10. Aside from the cortex what are the 2 major structures of LNs?

Answer 10

Medulla and sinus

Question 11

Q11: A swap of the wound has grown candida, name the 2 forms of candida that could be id under microscope?

Answer 11

Yeast and hyphae