Malignant melanoma #Oldstem

Question 1

Stem; a patient known to have hypothyroidism with a hard swelling in the inguinal region , the GP sent her for Biopsy .

Q1. If the inguinal LNS was lymphoma what are the distinct types Of lymphoma ?

Answer 1

Hodg and NH lymphoma

Question 2

Q2: How malignant cells survive in LNS?

Answer 2

As they produce VEGF that promote angiogenesis

Question 3

Q3: Why is melanoma pigmented ?

Answer 3

As it originate from melanocyte which produce melanin pigment

Question 4

Q4. Mention 4 types of melanoma ?

Answer 4

Superficial spreading / Desmoplastic / Nodular / Lentigo / Acral

Question 5

Q6. A lesion under the Toe nail was found and the decision to amputate the toe and excise the LNS was done , What is the objective behind this decision ?

Answer 5

To avoid local invasion /
distal mets and for function and pain control /
to control pain /
pt has lost function of organ/
recurrence after surgery

Question 6

Q7. What is Epitheloid Melanoma ?

Answer 6

Epithelioid cells are large and round with abundant eosinophilic cytoplasm, prominent vesicular nuclei and large nucleoli. They most commonly arise in superficial spreading and nodular melanomas.

Question 7

Q9: Gene mutation In familial malignant melanoma ?

Answer 7

BRAF

Question 8

Q10. Post operative the wound is red and swollen, culture revealed diplococci give examples ?

Answer 8

G-ve diplococci like N. meningetidies /hemophilus
**G+ve Enterococcus **

Question 9

Q11. Next the patient became toxic with rapid spread of infection what do you think the cause ?

Answer 9

Nec. Fasci.