Malignant melanoma #Oldstem Flashcards

Stem; a patient known to have hypothyroidism with a hard swelling in the inguinal region , the GP sent her for Biopsy .

1
Q

Stem; a patient known to have hypothyroidism with a hard swelling in the inguinal region , the GP sent her for Biopsy .

Q1. If the inguinal LNS was lymphoma what are the distinct types Of lymphoma ?

A

Hodg and NH lymphoma

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Q

Q2: How malignant cells survive in LNS?

A

As they produce VEGF that promote angiogenesis and produce immunosuppression materilas to enhance its servival

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3
Q

Q3: Why is melanoma pigmented ?

A

As it originate from melanocyte which produce melanin pigment

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4
Q

Q4. Mention 4 types of melanoma ?

A

Superficial spreading / Desmoplastic / Nodular / Lentigo / Acral

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5
Q

Q6. A lesion under the Toe nail was found and the decision to amputate the toe and excise the LNS was done , What is the objective behind this decision ?

A

To avoid local invasion /
distal mets and for function and pain control /
to control pain /
pt has lost function of organ/
recurrence after surgery

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6
Q

Q7. What is Epitheloid Melanoma ?

A

Epithelioid cells are large and round with abundant eosinophilic cytoplasm, prominent vesicular nuclei and large nucleoli. They most commonly arise in superficial spreading and nodular melanomas.

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7
Q

Q9: Gene mutation In familial malignant melanoma ?

A

BRAF

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8
Q

Q10. Post operative the wound is red and swollen, culture revealed diplococci give examples ?

A

G-ve diplococci like N. meningetidies /hemophilus
G+ve Enterococcus

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9
Q

Q11. Next the patient became toxic with rapid spread of infection what do you think the cause ?

A

Nec. Fasci.

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