Venous Thrombosis Flashcards
Is it platelets or fibrin than are the problem in arterial thrombosis?
Platelets
Are arterial thrombi venous or platelet rich?
Platelet
What are the tretament for arterial thrombus prevention?
Aspririn and other anti platelet drugs?
Are venous thrombus rich in platelets or fibrin?
Fibrin
Is it platelets or fibrin than are the problem in venous thrombosis?
Fibrin
What are the three components of virchow’s triad?
Stasis
Vessel wall damage
Hypercoaguability
What side of the hear is under strain if there is a PE?
Right
What are the risk factors for a DVT?
Age Marked obesity Pregnancy Puerperium Oestrogen therapy Previous DVT/PE Trauma/Surgery Malignancy Paralysis Infection Thrombophilia
Why is age a major risk factor for a DVT?
Valves don’t function as well as you get older.
What hormone raises the risk of a DVT?
Oestrogen
Familial or acquired disorders of the haemostatic mechanism which are likely to predispose to thrombosis.
Thrombophillia
What protein is responsible for switching of thrombin formation?
Anti thrombin 3
What does anti thrombin 3 do?
Switch of thrombin formation
What happens if you have a Factor V Leiden Mutation?
More likely to have a VTE (Factor 5 isn’t switched off as easily)
What are the 5 main hereditary thrombophilias?
Factor V Leiden Prothrombin 20210 mutation Antithrombin deficiency Protein C deficiency Protein S deficiency
When should you consider testing someone for a hereditary thrombophilia?
Venous thrombosis
How do you manage hereditary thombophilia?
- Advice of avoiding risk
(eg avoid COCP)
Heparin at high risk times eg after surgery, after delivery - Long term anticoagulation for thoses at highest risk of multiple events (usually after they have had one!) with heparin or warfarin.
A patient aged 40 has had a TIA. She has also had a DVT in the past and 3 miscarriages.
Antiphospholipid syndrome
Does having antiphospholipid antibodies activate primary or secondary haemostasis, or both?
Both
What is the APPT like in antiphospholipid syndrome?
Prolonged
Where is there a conformational change in antiphospholipid syndrome?
Beta 2 glycoprotein
