Anti thrombosis and anti platelet drugs

Question 1

What is atherosclerosis?

Answer 1

Damage to the endothelium and recruitment of foamy macrophages rrich in cholesterol which then results in plaque formation.

Question 2

What happens when the plaque ruptures in atherosclerosis?

Answer 2

Platelet recruitment and activation

Question 3

What is the target in preventing arterial thrombus?

Answer 3

Platelets

Question 4

How does aspirin work?

Answer 4

Inhibits Cyclo oxygenase which is necessary to produce thromboxane A2

Question 5

What does cycloxoygenase do?

Answer 5

Necessary to produce thromboxane

Question 6

What are the side effects of aspirin?

Answer 6

1. Bleeding
2. Blocks production of prostoglandins
3. GI ulceration
4. Bronchospasm

Question 7

What kind of drug is Clopidogrel?

Answer 7

ADP receptor antagonist

Question 8

In what condition is aspirin contraindicated?

Answer 8

Asthmas (Aspirin causes bronchospasm)

Question 9

What kind of drug s dipyridamole?

Answer 9

Phosphodiesterase inhibitor which reduces production of cAMP

Question 10

How long do you have to stop antiplatelet agents for before an operation?

Answer 10

7 days