Haemopoiesis Flashcards
What is the lifespan of neutrophils?
7 - 8 hours
What is the life span of a platelet?
7 - 10 days
What is the life span of a RBC?
120 days
Where do you usually find megakaryocytes?
Bone marrow
What do megakaryocytes differentiate into?
Platelets
What is the precursor cell for platelets?
Megakaryocytes
What is a myelocytes?
An intermediate nucleated precursor cell between neutrophils and blast cells?
What is meant by a “blast cell”
A nucleated precursor cell
What embryological layer are haemopoetic stem cells derived from?
Mesoderm
What is the first site of haemopoeisis in the embryo?
Yolk sac
What three organs perform haemopoiesis in the fetus?
Liver
Spleen
Bone marrow
What is the most common site of bone marrow biopsy in an adult?
Iliac crests
What is the name given to the interface between the bone marrow and the bone?
Endosteum
What are sinusoids in the bone?
Speciailised venules that form a reticular network of denestrated vessels. They regulat the passage os cell in and out of the circulation
What is meant by red bone marrow?
Haemopoitically actove marrow
What is meant by yellow bone marrow?
Fatty inactive marrow
What is meant by the myeloid erthyroid ratio?
relationship of neutrophils and precursors to proportion of nucleated red cell precursors (ranges from 1.5:1 to 3.3:1) – can change (eg reversal in haemolysis as a compensatory response)
What kind of cells does bone marrow aspirate look for?
Precursor cells
What three tests could you do to look for rare cell populations in haemopoiesis?
Immunophenotyping
Cytochemistry
Clonogenic assays
