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Haematology > Haemopoiesis > Flashcards

Haemopoiesis Flashcards

1
Q

What is the lifespan of neutrophils?

A

7 - 8 hours

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2
Q

What is the life span of a platelet?

A

7 - 10 days

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3
Q

What is the life span of a RBC?

A

120 days

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4
Q

Where do you usually find megakaryocytes?

A

Bone marrow

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5
Q

What do megakaryocytes differentiate into?

A

Platelets

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6
Q

What is the precursor cell for platelets?

A

Megakaryocytes

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7
Q

What is a myelocytes?

A

An intermediate nucleated precursor cell between neutrophils and blast cells?

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8
Q

What is meant by a “blast cell”

A

A nucleated precursor cell

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9
Q

What embryological layer are haemopoetic stem cells derived from?

A

Mesoderm

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10
Q

What is the first site of haemopoeisis in the embryo?

A

Yolk sac

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11
Q

What three organs perform haemopoiesis in the fetus?

A

Liver
Spleen
Bone marrow

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12
Q

What is the most common site of bone marrow biopsy in an adult?

A

Iliac crests

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13
Q

What is the name given to the interface between the bone marrow and the bone?

A

Endosteum

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14
Q

What are sinusoids in the bone?

A

Speciailised venules that form a reticular network of denestrated vessels. They regulat the passage os cell in and out of the circulation

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15
Q

What is meant by red bone marrow?

A

Haemopoitically actove marrow

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16
Q

What is meant by yellow bone marrow?

A

Fatty inactive marrow

17
Q

What is meant by the myeloid erthyroid ratio?

A

relationship of neutrophils and precursors to proportion of nucleated red cell precursors (ranges from 1.5:1 to 3.3:1) – can change (eg reversal in haemolysis as a compensatory response)

18
Q

What kind of cells does bone marrow aspirate look for?

A

Precursor cells

19
Q

What three tests could you do to look for rare cell populations in haemopoiesis?

A

Immunophenotyping
Cytochemistry
Clonogenic assays

Haematology (21 decks)

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