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Haematology > Lymphoma > Flashcards

Lymphoma Flashcards

1
Q

What is more common; T or B cell lymphoma?

A

B cell lymphoma

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2
Q

What is more common; Hodgekins or Non Hodgekins?

A

Non Hodgkins

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3
Q

Which type of hodgkins lymphoma is seen in a young people and is predominantely mediastinal involvement?

A

Nodular sclerosing

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4
Q

Which type of hodgkins lymphoma is see in older people and is most commonly involving the inguinal nodes?

A

Nodular lymphocytic

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5
Q

What is the pathopneumonic feature of hodgkins lymphoma or a peripheral blood smear?

A

Reed Sternberg Cell

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6
Q

In which type of lymphoma do you get alcohol induced pain?

A

Hodgkins lymphoma

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7
Q

What is the first line investigation for hodgkins lymphoma?

A

Lymph node biopsy

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8
Q

What types of lymphoma are associated with EBV?

A

Burkitt’s lymphoma

Hodgkins lymphoma

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9
Q

What type of lymphoma is associated with HTLV infection?

A

Adult T cell lymphoma

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10
Q

What type of lymphoma is associated with HIV?

A

Non hodgkins lymphoma

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11
Q

list some B cell symptoms?

A

Fever
Night sweats
Weight loss

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12
Q

Are the lymph nodes generally tender in lymphoma?

A

No

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13
Q

After you have found lymohoma on a lymph node biopsy what do you need to do next?

A

Immunohistochemistry (Looks at patterns of proteins on the surface on cell by using antibodies against these)
Immunophenotyping
Cytogenic analysis - FISH

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14
Q

What kind of cells does the lymph node cortex contain?

A

B cells

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15
Q

What kinds of cells does the lymph node paracortex contain?

A

T cells

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16
Q

What is in the medulla of a lymph node?

A

Cords and sinusoids

17
Q

What is the germinal centre of a lymoh node?

A

The place where white cells are primed with antigens

18
Q

What type of lymphoma is associated with the MYC translocation?

A

Burkitts lymphoma

19
Q

Where does a naive B cell from the bone marrow go in the lymph node once it encounters an antigen?

A 
Mantle zone (becomes a mantle cell)
Germinal centre (centroblast then a centrocyte
Marginal zone (marginal zone B cell)
Plasma cell
20
Q

What kind of lymphoma results from naive B cells?

A

Small lymphocytic B cell NHL

21
Q

What kind of lymphoma results from mantle cells?

A

Mantle cell B cell NHL

22
Q

What kind of lymphoma results from centroblast cells?

A

Diffuse large B cell NHL

23
Q

What kind of lymphoma results from centrocytes?

A

Follicular B cell NHL

24
Q

What kind of lymphoma originates in the marginal zone of the lymph node?

A

Marginal zone B cell NHL

25
Q

What are the two types of T cell NHL?

A

Cutaneous T Cell lymphoma (mycosis fungoides)

Enteropathy associated lymphoma (associated with coeliac disease)

26
Q

Which type of lymphoma is associated with coeliac disease?

A

Enteropathy associated lymphoma

27
Q

What are the three important high grade NHL lymphomas?

A

Burkitts

Diffuse Large B cell Mantle cell

28
Q

What are the three important low grade NHL lymphomas?

A

Small lymphocytic
Follicular
Marginal zone

29
Q

What is the chemotheraputic treatment of follicular cell lymphoma?

A

Anti CD20 (Rituximab)

30
Q

What is the most common symptoms of burkitts lymphoma in children?

A

Rapidly growing jaw mass

31
Q

What is the cause of waldenstroms macroglobinemia?

A

Uncontrolled clonal proliferation of terminally differentiated B lymphocytes

32
Q

What mutation is most commonly seen in waldenstroms macroglobinemia?

A

MYD88

33
Q

Which antibody has proliferated in waldenstroms macroglobinemia?

A

IgM

34
Q

What kind of cancer is waldenstroms macroglobinemia?

A

Lymphoplasmacytic lymphoma

35
Q

Which is the most common type of cancer in children?

A

Acute Lymphoblastic Leukemia

Haematology (21 decks)

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