Lymphoma

Question 1

What is more common; T or B cell lymphoma?

Answer 1

B cell lymphoma

Question 2

What is more common; Hodgekins or Non Hodgekins?

Answer 2

Non Hodgkins

Question 3

Which type of hodgkins lymphoma is seen in a young people and is predominantely mediastinal involvement?

Answer 3

Nodular sclerosing

Question 4

Which type of hodgkins lymphoma is see in older people and is most commonly involving the inguinal nodes?

Answer 4

Nodular lymphocytic

Question 5

What is the pathopneumonic feature of hodgkins lymphoma or a peripheral blood smear?

Answer 5

Reed Sternberg Cell

Question 6

In which type of lymphoma do you get alcohol induced pain?

Answer 6

Hodgkins lymphoma

Question 7

What is the first line investigation for hodgkins lymphoma?

Answer 7

Lymph node biopsy

Question 8

What types of lymphoma are associated with EBV?

Answer 8

Burkitt’s lymphoma

Hodgkins lymphoma

Question 9

What type of lymphoma is associated with HTLV infection?

Answer 9

Adult T cell lymphoma

Question 10

What type of lymphoma is associated with HIV?

Answer 10

Non hodgkins lymphoma

Question 11

list some B cell symptoms?

Answer 11

Fever
Night sweats
Weight loss

Question 12

Are the lymph nodes generally tender in lymphoma?

Answer 12

No

Question 13

After you have found lymohoma on a lymph node biopsy what do you need to do next?

Answer 13

Immunohistochemistry (Looks at patterns of proteins on the surface on cell by using antibodies against these)
Immunophenotyping
Cytogenic analysis - FISH

Question 14

What kind of cells does the lymph node cortex contain?

Answer 14

B cells

Question 15

What kinds of cells does the lymph node paracortex contain?

Answer 15

T cells

Question 16

What is in the medulla of a lymph node?

Answer 16

Cords and sinusoids

Question 17

What is the germinal centre of a lymoh node?

Answer 17

The place where white cells are primed with antigens

Question 18

What type of lymphoma is associated with the MYC translocation?

Answer 18

Burkitts lymphoma

Question 19

Where does a naive B cell from the bone marrow go in the lymph node once it encounters an antigen?

Answer 19

Mantle zone (becomes a mantle cell)
Germinal centre (centroblast then a centrocyte
Marginal zone (marginal zone B cell)
Plasma cell

Question 20

What kind of lymphoma results from naive B cells?

Answer 20

Small lymphocytic B cell NHL

Question 21

What kind of lymphoma results from mantle cells?

Answer 21

Mantle cell B cell NHL

Question 22

What kind of lymphoma results from centroblast cells?

Answer 22

Diffuse large B cell NHL

Question 23

What kind of lymphoma results from centrocytes?

Answer 23

Follicular B cell NHL

Question 24

What kind of lymphoma originates in the marginal zone of the lymph node?

Answer 24

Marginal zone B cell NHL

Question 25

What are the two types of T cell NHL?

Answer 25

Cutaneous T Cell lymphoma (mycosis fungoides) | Enteropathy associated lymphoma (associated with coeliac disease)

Question 26

Which type of lymphoma is associated with coeliac disease?

Answer 26

Enteropathy associated lymphoma

Question 27

What are the three important high grade NHL lymphomas?

Answer 27

Burkitts | Diffuse Large B cell Mantle cell

Question 28

What are the three important low grade NHL lymphomas?

Answer 28

Small lymphocytic Follicular Marginal zone

Question 29

What is the chemotheraputic treatment of follicular cell lymphoma?

Answer 29

Anti CD20 (Rituximab)

Question 30

What is the most common symptoms of burkitts lymphoma in children?

Answer 30

Rapidly growing jaw mass

Question 31

What is the cause of waldenstroms macroglobinemia?

Answer 31

Uncontrolled clonal proliferation of terminally differentiated B lymphocytes

Question 32

What mutation is most commonly seen in waldenstroms macroglobinemia?

Answer 32

MYD88

Question 33

Which antibody has proliferated in waldenstroms macroglobinemia?

Answer 33

IgM

Question 34

What kind of cancer is waldenstroms macroglobinemia?

Answer 34

Lymphoplasmacytic lymphoma

Question 35

Which is the most common type of cancer in children?

Answer 35

Acute Lymphoblastic Leukemia