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Clinical Pharm > Vasopressors/paralytics > Flashcards

Vasopressors/paralytics Flashcards

1
Q

Phenylepherine MOA

A

Pure Alpha 1

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2
Q

Phenylepherine infusion dose range

A

20-200 mcg/min

0.15-1.0 mcg/kg/min

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3
Q

Phenylepherine bolus dose

A

40-100 mcg

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4
Q

Phenylepherine considerations

A

Increased SVR

Reflex bradycardia

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5
Q

Ephedrine MOA

A

Alpha 1, Beta 1
Indirect>direct
Causes NE release

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6
Q

Ephedrine bolus dose

A

5-25 mg

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7
Q

Ephedrine considerations

A

Increase HR

Tachyphylaxis

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8
Q

Epinephrine MOA

A

Alpha 1
Beta 1
Beta 2

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9
Q

Epinephrine infusion dose range

A

1-20 mcg/min

0.01-0.3 mcg/kg/min

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10
Q

Epinephrine bolus dose

A

10-500 mcg

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11
Q

Norepinephrine MOA

A

Alpha 1

Beta 1

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12
Q

Norepinephrine infusion dose

A
  1. 5-30 mcg/min

0. 01-0.3 mcg/kg/min

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13
Q

Dopamine MOA

A

beta 1
Beta 2
Dopamine
Alpha 1

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14
Q

Dopamine infusion dose

A

1-20 mcg/kg/min

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15
Q

Vasopressin MOA

A

V1 SM

V2 CD

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16
Q

Vasopressin infusion dose

A

0.01-0.1 units/min

1-6 units/hr

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17
Q

Vasopressin bolus dose

A

1-10 units

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18
Q

Milrinone MOA

A

PDE III inhibitor

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19
Q

Milrinone infusion dose

A

0.375-0.75 mcg/kg/min

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20
Q

Milrinone bolus dose

A

50 mcg/kg over 10 minutes

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21
Q

Milrinone considerations

A

Increase CO and contractility

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22
Q

Phenylephrine concentration

A

100 mcg/mL

40 mcg/mL

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23
Q

Phenylephrine therapeutic effect

A

Increase SVR
Increase stroke volume
Increase venous return

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24
Q

Phenylephrine adverse effects

A

Reflex bradycardia

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25
Phenylephrine clearance
Hepatic metabolism | Renal elimination
26
Ephedrine concentration
Dilute to 5 or 10 mg/ml
27
Ephedrine therapeutic effect
Increase HR | Increase venous return
28
Ephedrine adverse effects
Increase MVO2
29
Ephedrine clearance
Renal elimination
30
Epinephrine concentration
1: 10,000 = 100 mcg/mL 1: 1,000 = 1 mg/mL
31
Epinephrine therapeutic effect
``` Increase SVR Increase HR Increase contraction Increase vascular resistance Bronchodilaton ```
32
Epinephrine adverse effects
Increase glucose | Arrhythmogenic
33
Epinephrine clearance
MAO/COMT
34
Norepinephrine concentrations
4 mg/250 mL D5W
35
Norepinephrine adverse effects
Constrict microvascular | Oliguria
36
Norepinephrine clearance
MAO/COMT
37
Dopamine concentration
4 mg/250 mL D5W
38
Dopamine dose vs. MOA
5-10 B1>a1 | 10-20 a1>B1
39
Dopamine adverse effects
Tachyphylaxis | Oliguria
40
Dopamine MOA
MAO/COMT
41
vasopressin concentration
1 unit/mL | 20 Units/mL in 20 mL NaCl
42
Vasopressin therapeutic effect
Increase SVR | Increase V1 smooth muscle
43
Vasopressin adverse effects
Pulmonary edema | GI ischemia
44
Vasopressin half life
10-20 min
45
Vasopressin clearance
Renal elimination
46
Milrinone concentration
50 mg/250 mL
47
Milrinone therapeutic effect
Increase contractility Increase CO Lusitropic Decrease PVR
48
Milrinone adverse effects
Decrease BP | Ventricular arrythmias
49
Milrinone clearance
Hepatic metabolism | Renal elimination
50
Rocuronium class
Steroid
51
Rocuronium intubating dose
0.6-1.2 mg/kg
52
Rocuronium bolus dose
5-10 mg
53
Rocuronium RSI dose
1.2 mg/kg
54
Rocuronium concentration
10 mg/ml
55
Rocuronium onset
60-90 seconds
56
Rocuronium duration
30-60 minutes
57
Rocuronium considerations
Anaphylactoid | No hemodynamics changes
58
Rocuronium clearance
60% hepatic | 30% renal
59
Rocuronium half life
1-2 hours
60
Vecuronium class
Steroid
61
Vecuronium intubating dose
0.1 mg/kg
62
Vecuronium bolus dose
1-4 mg
63
Vecuronium infusion dose
0.08-1.2 mcg/kg/min
64
Vecuronium concentration
1 mg/mL
65
Vecuronium onset
2-4 minutes
66
Vecuronium duration
30-60 minutes
67
Vecuronium considerations
Anaphylactoid | No hemodynamic changes
68
Vecuronium clearance
Hepatic 50% | Renal 50%
69
Pancuronium class
Steroid
70
Pancuronium intubating dose
0.1 mg/kg
71
Pancuronium bolus dose
1-2 mg
72
Pancuronium special considerations
Vagolytic
73
Pancuronium concentration
1 mg/ml
74
Pancuronium onset
2-4 min
75
Pancuronium duration
30-60 min
76
Pancuronium adverse effects
Increase HR, BP, CO
77
Pancuronium clearance
90% renal
78
Atracurium class
BISQ-AB
79
Atracurium intubating dose
0.5 mg/kg
80
Atracurium bolus dose
1-4 mg
81
Atracurium infusion dose
0.08-1.2 mcg/kg/min
82
Atracurium concentration
10 mg/ml
83
Atracurium onset
2-4 min
84
Atracurium duration
30-60 minutes
85
Atracurium clearance
Hofmann elimination | Plasma esterases
86
Cistracurium class
BISQ-AB
87
Cisatracurium intubating dose
0.15-0.2 mg/kg
88
Cisatracurium bolus dose
1-4 mg
89
Cisatracurium considerations
Renal/hepatic dysfunction
90
Cisatracurium concentration
2 mg/ml
91
Cisatracurium onset
2-4 min
92
Cisatracurium duration
30-60 minutes
93
Atracurium adverse effects
Increase HR Decrease SVR Histamine release
94
Cisatracurium clearance
Hofmann elimation | Plasma esterases
95
Cisatracurium adverse effects
None
96
Suxx class
Depolarizing
97
Suxx intubating dose
IV: 0.5-1.5 mg/kg IM: 2-3 mg/kg
98
Suxx contraindications
``` MH DMD Burns Rhbdo Paralysis ```
99
Suxx dose used to treat laryngospasm
2-3 mg/kg
100
Suxx concentration
20 mg/ml
101
Suxx onset
30-60 seconds
102
Suxx duration
5-10 min
103
Suxx adverse effects
Bradycardia Hyperkalemia Myalgias Increased ICP, IGP
104
Suxx clearance
Plasma pseudocholinesterase

Clinical Pharm (10 decks)

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