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Antihypertensives Flashcards

1
Q

metoprolol (lopressor) MOA

A

B1 blocker

B2 with increased dose

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2
Q

Metoprolol (lopressor) bolus dose

A

2.5-5 mg q 2 minutes

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3
Q

Metoprolol (lopressor) considerations

A
  • Bronchoconstriction

- Heart block

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4
Q

Esmolol (brevibloc) MOA

A

B1 blocker

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5
Q

Esmolol (Brevibloc) infusion dose

A

1-15 mg/min

50-500 mcg/kg/min

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6
Q

Esmolol (brevibloc) bolus dose

A

10-20 mg

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7
Q

Esmolol (brevibloc) loading dose

A

500 mcg/kg over 1 minute

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8
Q

Esmolol (brevibloc) considerations

A

PONV

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9
Q

Labetalol (normodyne) MOA

A

a1 blocker

B1 & B2 blocker

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10
Q

Labetalol (normodyne) infusion dose range

A

0.25 - 1.0 mg/kg

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11
Q

Labetalol (normodyne) bolus dose

A

5-20 mg q 5-10 min

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12
Q

Labetalol (normodyne) considerations

A 
Beta:alpha = 7:1
Max = 300 mg
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13
Q

Nitroprusside (nipride) MOA

A

direct NO donor - arterial and venous

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14
Q

Nitroprusside (nipride) infusion dose range

A

0.1-0.5 mcg/kg/min

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15
Q

Nitroprusside (nipride) bolus dose

A

20-40 mcg

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16
Q

nitroprusside (Nipride) considerations

A

Cyanide

Max dose = 10 mcg/kg/min

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17
Q

Nitroglycerin (Nitrol) with MOA

A

Vasodilator, venous>arterial

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18
Q

Nitroglycerine (Nitrol) infusion dose range

A

5-200 mcg/min

0.1-1.5 Mcg/kg/min

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19
Q

Nitroglycerine (Nitrol) bolus dose

A

10-20 mcg

give 5-10 mcg/min

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20
Q

Nitroglycerin (Nitrol) considerations

A

Hypotension

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21
Q

Nicardipine (Cardene) MOA

A

Ca Channel blocker

Dihydropyridine

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22
Q

Nicardipine (Cardene) infusion dose range

A

5-25 mg/hr

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23
Q

Nicardipine (Cardene) bolus dose

A

None

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24
Q

Nicardipine (Cardene) considerations

A

Reflex tachycardia

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25
Hydralazine (Apresoline) MOA
Vasodilator (arterial > venous)
26
Hydralazine (apresoline) bolus dose
2.5-20 mg IV q 4 hours
27
Hydralazine (apresoline) considerations
Max = 40 mg dose Reflex tachycardia Caution with CAD patients
28
metoprolol (Lopressor)concentration
1 mg/ml
29
Metoprolol (Lopressor) onset
2-5 min
30
Metoprolol (Lopressor) duration
6-12 hours
31
Metoprolol (Lopressor) metabolization:elimination
Hepatic:Renal
32
Betablocker effects
Decrease CO, decrease inotropy, decrease HR, decrease MAP, Labetalol: decrease SVR
33
Esmolol (Brevibloc) concentration
10 mg/ml
34
Esmolol (Brevibloc) onset
2 min
35
Esmolol (Brevibloc) duration
9-20 min
36
Esmolol (Brevibloc) metabolism:elimination
Nonspecific esterases
37
Nitroprusside (Nipride) concentrations
400 mcg/ml | 100 mg:250 ml
38
Nitroprusside (Nipride) onset
39
Nitroprusside (Nipride) duration
1-10 min
40
Nitroprusside (Nipride) metabolism/elimination
RBC + Tissue, renal
41
Nitroprusside (Nipride) effects
-- MAP, -- SVR
42
Labetalol (Normodyne) concentration
5 mg/ml
43
Labetalol (Normodyne) onset
1-2 min
44
Labetalol (Normodyne) duration
2-8 hours
45
Labetalol (normodyne) metabolism/elimination
Hepatic:renal
46
Nitroglycerin (Nitrol) concentration
100 mcg/mL | 25 mg/250 ml
47
Nitroglycerin (Nitrol) onset
1-2 min
48
Nitroglycerin (Nitrol) duration
3-6 hours
49
Nitroglycerin (Nitrol) metabolism/elimination
Hepatic/renal
50
Nitroglycerin (Nitrol) effects
-- preload, - MvO2
51
Nicardipine (Cardene) concentration
100 mcg/ml | 25 mg/250 ml
52
Nicardipine (Cardene) onset
1-5 min
53
Nicardipine (Cardene) duration
3-6 hours
54
Nicardipine (Cardene) metabolism:elimination
Hepatic:renal
55
Nicardipine (Cardene) effects
-- MAP, -- SVR
56
Hydralazine (apresoline) concentration
20 mg/mL
57
Hydralazine (apresoline) onset
5-20 min
58
Hydralazine (apresoline) duration
4-8 hours
59
Hydralazine (apresoline) metabolism:elimination
Hepatic:renal
60
Hydralazine (apresoline) effects
- MAP: - SVR | - PVR

Clinical Pharm (10 decks)

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