Local Anesthetics Flashcards by Hali Haukos | Brainscape

Q

Esters

A

One “i”

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Q

Amides

A

Two “i”

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Q

Procaine class

A

Ester

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Q

Procaine pKa

A

8.9

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Q

Procaine relative potency

A

1

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Q

Procaine onset

A

2-5 min

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Q

Procaine duration

A

25-60 min

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Q

Procaine max dose

A

7 mg/kg

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Q

Procaine max dose with epi

A

10 mg/kg

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Q

Procaine max total dose

A

350-600 mg

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Q

Procaine concentrations with clinical use

A

Spinal 10%

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Q

Chloroprocaine class

A

Ester

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Q

Chloroprocaine pKa

A

8.7

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Q

Chloroprocaine relative potency

A

8

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Q

Chloroprocaine onset

A

5-10 min

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Q

Chloroprocaine duration

A

15-30 min

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Q

Chloroprocaine max dose

A

11 mg/kg

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Q

Chloroprocaine max dose with epi

A

14 mg/kg

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Q

Chloroprocaine max total dose

A

800 mg

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Q

Chloroprocaine concentrations with clinical use

A

epidural 2-3%

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Q

Bupivacaine class

A

Amide

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Q

Bupivacaine pKa

A

8.1

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Q

Bupivacaine relative potency

A

8

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Q

Bupivacaine onset

A

5-10 minutes

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Q

Bupivacaine duration

A

2-4 hours

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Q

Bupivacaine duration with epi

A

3-7 hours

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Q

Bupivacaine max dose

A

2.5 mg/kg

Q

Bupivacaine max dose with epi

A

3 mg/kg

Q

Bupivacaine max total dose

A

175 mg

Q

Bupivacaine max total dose with epi

A

225 mg

Q

Bupivacaine concentrations with clinical uses

A

epidural/spinal 0.5-0.75%

Peripheral nerve block 0.25-0.5%

Q

Ropivacaine class

A

Amide

Q

Ropivacaine pKa

A

8.1

Q

Ropivacaine relative potency

A

6

Q

Ropivacaine onset

A

10-15 minutes

Q

Ropivacaine duration

A

2-6 hours

Q

Ropivacaine max dose

A

5 mg/kg

Q

Ropivacaine max total dose

A

200 mg

Q

Ropivacaine concentrations with clinical use

A

Epidural, spinal, peripheral nerve block 0.5-1%

Q

Lidocaine class

A

Amide

Q

Lidocaine pKa

A

7.9

Q

Lidocaine relative potency

A

2

Q

Lidocaine onset

A

Q

Lidocaine duration

A

30 min - 2 hours

Q

Lidocaine duration with epi

A

2-6 hours

Q

Lidocaine max dose

A

4.5 mg/kg

Q

Lidocaine max dose with epi

A

7 mg/kg

Q

Lidocaine max total dose

A

300 mg

Q

Lidocaine concentrations with clinical use

A

Bier block 0.25-0.5%

Peripheral nerve block 1-1.5%

Q

Prilocaine class

A

Amide

Q

Prilocaine pKa

A

7.9

Q

Prilocaine relative potency

A

2

Q

Prilocaine onset

A

Q

Prilocaine duration

A

60-90 minutes

Q

Prilocaine max dose

A

6 mg/kg

Q

Prilocaine max dose with epi

A

9 mg/kg

Q

Prilocaine max total dose

A

70 Kg - 600 mg

Q

Prilocaine concentration with clinical use

A

Epidural 2-3%

Peripheral nerve block 0.5-1%

Q

Mepivacaine class

A

Amide

Q

Mepivacaine pKa

A

7.6

Q

Mepivacaine relative potency

A

2

Q

Mepivacaine onset

A

3-5 minutes

Q

Mepivacaine duration

A

60-90 minutes

Q

Mepivacaine duration with epi

A

2-6 hours

Q

Mepivacaine max dose

A

7 mg/kg

Q

Mepivacaine max total dose

A

400 mg

Q

Mepivacaine concentration with clinical use

A

0.5-1%