Local Anesthetics Flashcards
1
Q
Esters
A
One “i”
2
Q
Amides
A
Two “i”
3
Q
Procaine class
A
Ester
4
Q
Procaine pKa
A
8.9
5
Q
Procaine relative potency
A
1
6
Q
Procaine onset
A
2-5 min
7
Q
Procaine duration
A
25-60 min
8
Q
Procaine max dose
A
7 mg/kg
9
Q
Procaine max dose with epi
A
10 mg/kg
10
Q
Procaine max total dose
A
350-600 mg
11
Q
Procaine concentrations with clinical use
A
Spinal 10%
12
Q
Chloroprocaine class
A
Ester
13
Q
Chloroprocaine pKa
A
8.7
14
Q
Chloroprocaine relative potency
A
8
15
Q
Chloroprocaine onset
A
5-10 min
16
Q
Chloroprocaine duration
A
15-30 min
17
Q
Chloroprocaine max dose
A
11 mg/kg
18
Q
Chloroprocaine max dose with epi
A
14 mg/kg
19
Q
Chloroprocaine max total dose
A
800 mg
20
Q
Chloroprocaine concentrations with clinical use
A
epidural 2-3%
21
Q
Bupivacaine class
A
Amide
22
Q
Bupivacaine pKa
A
8.1
23
Q
Bupivacaine relative potency
A
8
24
Q
Bupivacaine onset
A
5-10 minutes
25
Bupivacaine duration
2-4 hours
26
Bupivacaine duration with epi
3-7 hours
27
Bupivacaine max dose
2.5 mg/kg
28
Bupivacaine max dose with epi
3 mg/kg
29
Bupivacaine max total dose
175 mg
30
Bupivacaine max total dose with epi
225 mg
31
Bupivacaine concentrations with clinical uses
epidural/spinal 0.5-0.75%
| Peripheral nerve block 0.25-0.5%
32
Ropivacaine class
Amide
33
Ropivacaine pKa
8.1
34
Ropivacaine relative potency
6
35
Ropivacaine onset
10-15 minutes
36
Ropivacaine duration
2-6 hours
37
Ropivacaine max dose
5 mg/kg
38
Ropivacaine max total dose
200 mg
39
Ropivacaine concentrations with clinical use
Epidural, spinal, peripheral nerve block 0.5-1%
40
Lidocaine class
Amide
41
Lidocaine pKa
7.9
42
Lidocaine relative potency
2
43
Lidocaine onset
44
Lidocaine duration
30 min - 2 hours
45
Lidocaine duration with epi
2-6 hours
46
Lidocaine max dose
4.5 mg/kg
47
Lidocaine max dose with epi
7 mg/kg
48
Lidocaine max total dose
300 mg
49
Lidocaine concentrations with clinical use
Bier block 0.25-0.5%
| Peripheral nerve block 1-1.5%
50
Prilocaine class
Amide
51
Prilocaine pKa
7.9
52
Prilocaine relative potency
2
53
Prilocaine onset
54
Prilocaine duration
60-90 minutes
55
Prilocaine max dose
6 mg/kg
56
Prilocaine max dose with epi
9 mg/kg
57
Prilocaine max total dose
70 Kg - 600 mg
58
Prilocaine concentration with clinical use
Epidural 2-3%
| Peripheral nerve block 0.5-1%
59
Mepivacaine class
Amide
60
Mepivacaine pKa
7.6
61
Mepivacaine relative potency
2
62
Mepivacaine onset
3-5 minutes
63
Mepivacaine duration
60-90 minutes
64
Mepivacaine duration with epi
2-6 hours
65
Mepivacaine max dose
7 mg/kg
66
Mepivacaine max total dose
400 mg
67
Mepivacaine concentration with clinical use
0.5-1%
