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IV Anesthetic Agents Flashcards

1
Q

Propofol class

A

Sedative hypnotic

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2
Q

Propofol MOA

A

GABA-A

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3
Q

Propofol intubating dose

A

1-3 mg/kg

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4
Q

Propofol bolus dose

A

10-50 mg

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5
Q

Propofol infusion dose

A

50-300 mcg/kg/min

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6
Q

Etomidate class

A

Non-barb. Hypnotic

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7
Q

Etomidate MOA

A

GABA-A

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8
Q

etomidate intubating dose

A

0.2-0.4 mg/kg

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9
Q

Etomidate considerations (4)

A

Decrease CMRO2
Decrease CBF
Causes adrenal suppression
Cardiac stability

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10
Q

Ketamine class

A

Dissociative anesthetic

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11
Q

Ketamine MOA

A

NMDA antagonist

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12
Q

Ketamine IV intubating dose

A

0.5-2 mg/kg

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13
Q

Ketamine IM intubating dose

A

4-10 mg/kg

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14
Q

Ketamine bolus dose

A

10-30 mg

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15
Q

Ketamine considerations

A
  • bronchodilator

- Increase HR, BP, CO

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16
Q

Thiopental class

A

Barb

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17
Q

Thiopental MOA

A

GABA-A

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18
Q

Thiopental intubating dose

A

3-5 mg/kg

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19
Q

Thiopental considerations (3)

A

Decrease CMRO2
Decrease CBF
– BP

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20
Q

Methohexital class

A

Barb

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21
Q

Methohexital MOA

A

GABA-A

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22
Q

Methohexital intubating dose

A

1-2 mg/kg

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23
Q

Methohexital considerations

A

Apnea

Eye block: cardioversion

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24
Q

Remifentanil class

A

Opiate

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25
Remifentanil MOA
Mu agonist
26
Remifentanil intubating dose
0.5-1 mcg/kg/min - intubate after 8 min
27
Remifentanil drip dose
0.02-0.2 mcg/kg/HR
28
Remifentanil considerations
Dose IBW for obese patients
29
Precedex MOA
Alpha 2 agonist
30
Precedex intubating dose
0.5-1.0 mcg/kg over 10-30 minutes
31
Precedex drip rate
0.2-1.0 mcg/kg/hr
32
Precedex considerations
Causes sedation without respiratory depression
33
Propofol concentration
10 mg/ml
34
Propofol onset
30-60 sec
35
Propofol duration
2-8 minutes
36
Propofol metabolism
Liver/kidney
37
Propofol T 1/2
1-2 hours
38
Propofol adverse effects
Decreased BP, HR, contractility, PRIS
39
Etomidate concentration
2 mg/ml
40
Etomidate onset
60 seconds
41
Etomidate duration
3 min
42
Etomidate metabolism
Liver:kidney
43
Etomidate T 1/2
3-5 hours
44
Etomidate adverse effects
PONV | Myoclonus
45
Ketamine concentrations
50 mg/ml
46
Ketamine onset
60 sec
47
Ketamine duration of action
5-10 min
48
Ketamine metabolism
Liver
49
Ketamine T 1/2
2-3 hours
50
Ketamine adverse effects
Increased secretions | Emergence delirium
51
Thiopental concentration
25 mg/ml
52
Thiopental onset
30-60 min
53
Thiopental duration
10-30 min
54
Thiopental metabolism
Liver
55
Thiopental T 1/2
10-12 hours
56
Thiopental adverse effects
Induces CYP450 Decreases BP No barbs in pt's with porphyrias
57
Methohexital concentration
10 mg/ml
58
Methohexital onset
30-60 min
59
Methohexital duration
5-10 min
60
Methohexital metabolism
Liver
61
Methohexital T 1/2
4 hours
62
Methohexital adverse effects
No barbs in pt's with porphyrias
63
Remifentanil concentration
50 mcg/ml
64
Remifentanil onset
60-90 seconds
65
Remifentanil duration
4-8 minutes
66
Remifentanil metabolism
RBC/Tissue esterase
67
Remifentanil T 1/2
Rapid off
68
Remifentanil adverse effects
Hyperalgesia | Apnea
69
Precedex concentration
100 mcg/ml
70
Precedex onset
5-10 min
71
Precedex metabolism
Liver/kidney
72
Precedex T 1/2
2-3 hours
73
Precedex adverse effects
Decreased HR, BP | Alpha 2: alpha 1 = 1620:1

Clinical Pharm (10 decks)

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