Vasopressors; Cardiac Stimulators

Question 1

Norepinephrine
1.) Drug class?

Epinephrine

1. ) Drug class
2. ) low dose vs. high dose ?

Answer 1

1.)NE: excellent α-1 agonist

1.) E: non-selective adrenergic agonist
→ β-1= β-2&raquo_space;α-1=α-2
→ → low dose: β driven effect
→ → high dose: α-1 effect

Question 2

D1 receptor subtype has an effect on ?

Answer 2

• Coronary vessels→ Vasodilation

- Renal vessels→ Increased GFR; Diuresis (↑ production of urine)

Question 3

Low IV Dopamine infusion ?

Answer 3

D1 stimulation onlu → renal benefit

Question 4

Intermediate IV Dopamine infusion ?

Answer 4

Beta1 + D1

Renal benefit and ↑ cardiac output

Question 5

High IV Dopamine infusion ?

Answer 5

alpha-1 + β-1

• vasoconstriction→ ↑ CO
• ↑ systemic vascular resistance
• no more renal benefit

Question 6

Benefits of giving IV Dopamine

Answer 6

• beneficial in severe CHF with fluid overload

- benefit in cardiogenic or septic shock