Parathyroid

Question 1

Vitamin D
1.) What is its role?

2. ) what stimulates the production of Vitamin D
3. ) What inhibits the production of Vitamin D

Answer 1

• Principal regulator of intestinal Ca and P absorption
  2. ) PTH stimulates vit d production
  3. ) FGF23 (Opposes PTH) and inhibits PTH production

Question 2

What is the role of Calcitonin

Answer 2

sense high serum [Ca/P] and inhibits osteoclast activity to reduce serum [Ca/P]

Question 3

Cinacalcet

1. ) Drug class?
2. ) MOA?
3. ) Indication
4. ) ADR/CI?

Answer 3

1.) Calcimimetic
2.) ↑ density of calcium sensing receptors (CaSR) in parathyroid glands→ result is an inhibition of PTH secretion (fools PT by thinking it has enough Ca+ in blood)
3.) 2ndary HYPERparathyroidism due to CKD
4.) N/V/D
C/I - hypocalcemia

Question 4

Teriparatide

1. ) Drug class?
2. ) Indication?
3. ) what high or low doses?
4. ) ADR?

Answer 4

1. ) Recombinant PTH
2. ) treatment of osteoporosis → increases osteoblast activity
3. ) Low intermittent dosing
4. ) BBW-↑ risk of osteosarcoma after 2 years of use

Question 5

Abaloparatide

1. ) Drug class?
2. ) Indication?

Answer 5

1. ) Recombinant PTH

2. ) treatment of osteoporosis in postmenopausal women

Question 6

Calcitriol/Cholecalciferol (D3); ergocalciferol

1.) MOA?

Answer 6

1.) ↑ calcium absorption in intestine (primary)

Question 7

Calcium Salts

1. ) Indication ?
2. ) Drug class?

Answer 7

1. ) reduces hyperparathyroidism that occurs age
   - ( increased calcium levels reduce PTH)

2.) Anti-resorptive agent
(reduce osteoclast activity to ↑ BMD)

Question 8

SERM’s MOA?

Answer 8

activates estrogen receptors in bone =↑ BMD; reduced resorption

Question 9

Alendronate

1. ) Drug class?
2. ) MOA?
3. ) ADR?

Answer 9

1. ) Bisphosphonates-antiresorptive
2. ) Binds serum calcium calts→ complex becomes incorporated into the bone matrix
3. ) Erosive esophagitis

Question 10

Etidronate

1. ) Drug class?
2. ) MOA?
3. ) ADR?

Answer 10

1. ) Bisphosphonates (anti-resorptive)
2. ) Binds serum calcium calts→ complex becomes incorporated into the bone matrix
3. ) Erosive esophagitis

Question 11

Ibandronate

1. ) Drug class?
2. ) MOA?
3. ) ADR?

Answer 11

1. ) Bisphosphonates (anti-resorptive)
2. ) Binds serum calcium calts→ complex becomes incorporated into the bone matrix
3. ) Erosive esophagitis

Question 12

Pamidronate

1. ) Drug class?
2. ) MOA?
3. ) ADR?

Answer 12

1. ) Bisphosphonates (anti-resorptive)
2. ) Binds serum calcium calts→ complex becomes incorporated into the bone matrix
3. ) Erosive esophagitis

Question 13

Risedronate

1. ) Drug class?
2. ) MOA?
3. ) ADR?

Answer 13

1. ) Bisphosphonates (anti-resorptive)
2. ) Binds serum calcium calts→ complex becomes incorporated into the bone matrix
3. ) Erosive esophagitis

Question 14

Zoledronic acid

1. ) Drug class?
2. ) MOA?
3. ) ADR?

Answer 14

1. ) Bisphosphonates (anti-resorptive)
2. ) Binds serum calcium calts→ complex becomes incorporated into the bone matrix
3. ) Erosive esophagitis

Question 15

Denosumab

1. ) Drug class?
2. ) MOA?
3. ) ADR?

Answer 15

1. ) Monoclonal antibody-(anti-resorptive)-Treats osteoporosis
2. ) Inhibits action of RANK-L
3. ) ↑ risk of infection b/c of RANK-L being present on cells in immune system