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Pharm II Old Stuff Final > Adrenergics > Flashcards

Adrenergics Flashcards

1
Q

Guanfacine

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-2 agonist
  2. ) ADHD (hyperactive control)
  3. ) extension of pharmacological profile
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2
Q

Brimonidine

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-2 agonist
  2. )eyedrops for glaucoma
  3. ) extension of pharmacological profile
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3
Q

Methyldopa

A
  1. ) Selective α-2 agonist
  2. )FAVORABLE drug for HTN in pregnancy**
  3. ) extension of pharmacological profile
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4
Q

Clonidine

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-2 agonist
  2. )HTN**; ADHD; Withdrawal
  3. ) extension of pharmacological profile
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5
Q

α-1 subtypes:

  • 1A?
  • 1B/1D
  • 1D (specifically)

What happens when you antagonize 1A/1D?

A

1A→ Prostate smooth muscle contraction
1B/1D→ vascular smooth muscle contraction
1D→ Bladder neck

Antagonize 1A/1D→ BPH relief (↑ urinary flow)

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6
Q

Arformoterol

1.) Drug class?

A

1.) Selective β -2 Agonist

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7
Q

Indacaterol

1.) Drug class?

A

1.) Selective β -2 Agonist

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8
Q

Atomoxetine

  1. ) Drug class?
  2. ) Indication?
A
  1. ) Indirect sympathomimetic

2. )– Non-stimulant for treatment of ADHD =↑ [NE]

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9
Q

Terazosin

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-1 Antagonist
  2. ) HTN and BPH**
  3. ) First dose phenomenon → orthostatic hypotension
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10
Q

Nadolol

  1. ) Drug class?
  2. ) Indications?
A
  1. ) Non-selective β-antagonist
  2. )
    - Glaucoma
    - HTN
    - Migrane prophylaxsis
    - Portal HTN/esophageal varices
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11
Q

Alfuzosin

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-1 Antagonist
  2. ) BPH
  3. ) First dose phenomenon → orthostatic hypotension
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12
Q

Labetalol

  1. ) Drug class
  2. ) Indication?
A
  1. ) β-1, β-2, α-1 (ANTAGONIST)

2. ) HTN in pregnancy ***

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13
Q

Metoprolol

1.) Drug class?

A

1.) Selective β -1 Antagonists

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14
Q

Atenolol

1.) Drug class?

A

1.) Selective β -1 Antagonists

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15
Q

Salmeterol

1.) Drug class?

A

1.) Selective β -2 Agonist

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16
Q

Metipranolol

  1. ) Drug class?
  2. ) Indications?
A
  1. ) Non-selective β-antagonist
  2. )
    - Glaucoma
    - HTN
    - Migrane prophylaxsis
    - Portal HTN/esophageal varices
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17
Q

Tizanidine

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-2 agonist
  2. )HTN**; ADHD; Withdrawal
  3. ) extension of pharmacological profile
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18
Q

Alfuzosin

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-1 Antagonist
  2. ) BPH
  3. ) First dose phenomenon → orthostatic hypotension
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19
Q

Olodaterol

1.) Drug class?

A

1.) Selective β -2 Agonist

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20
Q

Mirabegron

  1. ) Drug class
  2. ) indication
A
  1. ) Selective β-3 agonist (detrusor)

2. ) Overactive bladder → drug will increase bladder capacity during storage phase

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21
Q

Isoproterenol

  1. ) Drug class?
  2. ) Indication?
A
  1. ) Non-selective β-agonist

2. ) for β-1 effect (positive inotrope)

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22
Q

Doxazosin

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-1 Antagonist
  2. ) HTN and BPH**
  3. ) First dose phenomenon → orthostatic hypotension
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23
Q

Phenylephrine

  1. ) Drug class
  2. ) Indication
A
  1. )Selective α-1 Agonist
  2. )
    - cold/cough→ weaker sudafed
    - IV vasopressor (↑ BP via vasoconstriction; useful for shock and hypoTN)
    - eyedrops
24
Q

Modafinil

  1. ) Drug class?
  2. ) Indication?
A
  1. ) Indirect sympathetic

2. )treatment for narcolepsy

25
Q

Metaproterenol

  1. ) Drug class?
  2. ) Indication?
A
  1. ) Non-selective β-agonist

2. ) for β-2 effect (asthma; COPD)

26
Q

Central Stimulants: Non-Amphetamines

  1. ) MOA?
  2. ) Agents available?
A 
1.) Similar effect/use as amphetamines but mediated primarily by DA reuptake blockade**** (less NE effects)
→ less jittery 
2.) 
-Methylphenidate
-Dexmethylphenidate
27
Q

Midodrine

  1. ) Drug class
  2. ) Indication
A
  1. ) Selective α-1 Agonist

2. ) Treatment of orthostatic hypotension

28
Q

Carteolol

  1. ) Drug class?
  2. ) Indications?
A
  1. ) Non-selective β-antagonist
  2. )
    - Glaucoma
    - HTN
    - Migrane prophylaxsis
    - Portal HTN/esophageal varices
29
Q

Esmolol

1.) Drug class?

A

1.) Selective β -1 Antagonists

30
Q

Dobutamine

  1. ) Drug class
  2. ) Effect?
  3. ) Indication?
A
  1. ) Selective β-1 agonist
  2. ) ↑ inotropic effects
  3. ) Shock and acute CHF
31
Q

Albuterol/levalbuterol

1.) Drug class?

A

1.) Selective β -2 Agonist

32
Q

Betaxolol

1.) Drug class?

A

1.) Selective β -1 Antagonists

33
Q

Dexmedetomidine

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-2 agonist
  2. )IV sedative
  3. ) extension of pharmacological profile
34
Q

What three drugs are best for systolic heart failure?

A
  • Carvedilol
  • Metoprolol
  • Bisoprolol
35
Q

Bisoprolol

1.) Drug class?

A

1.) Selective β -1 Antagonists

36
Q

Prazosin

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-1 Antagonist
  2. ) HTN and BPH and PTSD nightmares**
  3. ) First dose phenomenon → orthostatic hypotension
37
Q

Pseudoephedrine

  1. ) Drug class
  2. ) Indication
A
  1. ) Selective α-1 Agonist

2. ) Nasal decongestant for cough/cold

38
Q

Phenoxybenzamine

  1. ) Drug class?
  2. ) Indication?
A
  1. ) Non-Selective α-antagonists

2. ) Pheochromocytoma

39
Q

Acebutolol

1.) Drug class?

A

1.) Selective β -1 Antagonists

40
Q

Propranolol

  1. ) Drug class?
  2. ) Indications?
A
  1. ) Non-selective β-antagonist
  2. )
    - Glaucoma
    - HTN
    - Migrane prophylaxsis
    - Portal HTN/esophageal varices
41
Q

Carvedilol

  1. ) Drug class?
  2. ) Indications?
A
  1. ) β-1, β-2, α-1 (ANTAGONIST)

2. ) Heart failure

42
Q

Levobunolol

  1. ) Drug class?
  2. ) Indications?
A
  1. ) Non-selective β-antagonist
  2. )
    - Glaucoma
    - HTN
    - Migrane prophylaxsis
    - Portal HTN/esophageal varices
43
Q

Sotalol

  1. ) Drug class?
  2. ) Indications?
A
  1. ) Non-selective β-antagonist
  2. )
    - Glaucoma
    - HTN
    - Migrane prophylaxsis
    - Portal HTN/esophageal varices
44
Q

Formoterol

1.) Drug class?

A

1.) Selective β -2 Agonist

45
Q

Tamsulosin

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-1 Antagonist
  2. ) BPH
  3. ) First dose phenomenon → orthostatic hypotension
46
Q

Terbutaline

1.) Drug class?

A

1.) Selective β -2 Agonist

47
Q

Inotrope?
Chronotrope?
Dromotrope?

A 
• Inotrope
– Contractility (FOC) 
– Stroke volume (SV)
• Chronotrope(SANode)
– Heart rate
• Dromotrope (AV Node)
– Conduction velocity
48
Q

Pindolol

  1. ) Drug class?
  2. ) Indications?
A
  1. ) Non-selective β-antagonist
  2. )
    - Glaucoma
    - HTN
    - Migrane prophylaxsis
    - Portal HTN/esophageal varices
49
Q

Timolol

  1. ) Drug class?
  2. ) Indications?
A
  1. ) Non-selective β-antagonist
  2. )
    - Glaucoma
    - HTN
    - Migrane prophylaxsis
    - Portal HTN/esophageal varices
50
Q

Cocaine

  1. ) Drug class?
  2. ) therapeutic use?
A
  1. ) Indirect sympathomimetic

2. ) Topical local anesthesia (sodium channel inhibitor)

51
Q

Oxymetazoline

  1. ) Drug class
  2. ) Indication
A
  1. ) Selective α-1 Agonist

2. ) Nasal spray (too much for too long can put hole in nasal passage)

52
Q

Nebivolol

1.) Drug class?

A

1.) Selective β -1 Antagonists

53
Q

Central Stimulants: Amphetamines

  1. )MOA
  2. ) Drugs available?
A
  1. ) Promote release of NE (primarily)*** and DA (at high
    dose) from pre-synaptic storage into synapse
  2. )

Amphetamine;dextroamphetamine(Adderall) -Dextroamphetamine (Dexedrine)

  • Lisdexamfetamine(Vyvanse)
  • Methamphetamine(Desoxyn)
54
Q

Silodosin

  1. ) Drug class
  2. ) Indication
  3. ) ADR
A
  1. ) Selective α-1 Antagonist
  2. ) BPH*** Most selective to α- 1A receptor
  3. ) First dose phenomenon → orthostatic hypotension
55
Q

Oxymetazoline

  1. ) Drug class
  2. ) Indication
A
  1. ) Selective α-1 Agonist

2. ) Nasal spray (too much for too long can put hole in nasal passage)

56
Q

Phentolamine

  1. ) Drug class?
  2. ) Indication?
A

1.) Non-Selective α-antagonists 2.) Pheochromocytoma

Pharm II Old Stuff Final (19 decks)

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