Growth Hormone

Question 1

GHRH stimulates anterior pituitary to release ?

Answer 1

GH

Question 2

GH acts on the liver to release ?

Answer 2

insulin-like growth factor-1 (IGF-1)

Question 3

Growth Hormone can cause

What inhibits growth hormone?

Answer 3

1. )
   - ↑ gluconeogenesis
   - ↑ blood glucose
   - ↓ insulin sensitivity -
   - Bone and tissue growth
   - ↑ lipolysis

• FYI- High insulin sensitivity allows the cells of the body to use blood glucose more effectively, reducing blood sugar. … Low insulin sensitivity is known as insulin resistance.
  2. ) somatostatin or negative feed back from (IGF-1)

Question 4

Tesamorelin

1. ) Drug class
2. ) ADR?

Answer 4

1. ) Recombinant GHRH

2. ) Hyperglycemia

Question 5

Somatropin

1. ) Drug class
2. ) ADR?

Answer 5

1. ) Recombinant GH

2. ) Hyperglycemia

Question 6

Mescasermin

1. ) Drug class
2. ) ADR?

Answer 6

1.) Recombinant IGF-1
2.) HYPOglycemia
→ consume with carb containing meal

Question 7

Octreotide
Lanreotide
Pasireotide

1.)Drug Class?

Answer 7

1.) Somatostatin agonist (inhibits growth hormone)

Question 8

Pegvisomant

1. ) Drug class
2. ) MOA?
3. ) Indication

Answer 8

1. ) GH receptor Antagonist
2. ) ↓ production of IGF-1
3. ) Pituitary tumor → excess GH production